2024
Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Dietz N, Kumar C, Elsamadicy A, Bjurström M, Wong K, Jamieson A, Sharma M, Wang D, Ugiliweneza B, Drazin D, Boakye M. Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up. Scientific Reports 2024, 14: 25340. PMID: 39455709, PMCID: PMC11511981, DOI: 10.1038/s41598-024-76248-6.Peer-Reviewed Original ResearchConceptsDegenerative lumbar pathologySurgical site infectionSpinal surgeryPolypharmacy groupSite infectionLumbar pathologyFollow-upMedical complicationsElective lumbar spinal surgeryLumbar spinal surgeryUrinary tract infectionDegenerative lumbar conditionsReturn to the emergency departmentTract infectionsNon-polypharmacy groupSurgical patientsLumbar conditionsSurgeryPatientsComplicationsPolypharmacyEmergency departmentPrescribed medicationsMarketScan datasetDegenerative conditionsEfficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis
Aghajanian S, Mohammadifard F, Kohandel Gargari O, Naeimi A, Bahadorimonfared A, Elsamadicy A. Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis. Neurosurgical Review 2024, 47: 177. PMID: 38644447, DOI: 10.1007/s10143-024-02424-x.Peer-Reviewed Original ResearchConceptsNetwork meta-analysisRate of complicationsBlood lossSpine surgeryEpsilon-aminocaproic acidMeta-analysisTranexamic acidEfficacy of antifibrinolyticsPediatric spine surgeryPerioperative blood lossReduce blood lossStandardized outcome dataRandomized clinical trialsStandard of carePerioperative bleedingTransfusion volumeTransfusion rateAntifibrinolytic agentsMassive transfusionPediatric patientsSafety profilePediatric surgeryProbability of efficacyAntifibrinolyticsClinical trialsRacial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis
Elsamadicy A, Sayeed S, Sherman J, Hengartner A, Pennington Z, Hersh A, Lo S, Shin J, Mendel E, Sciubba D. Racial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis. Journal Of Neuro-Oncology 2024, 166: 293-301. PMID: 38225469, DOI: 10.1007/s11060-023-04557-3.Peer-Reviewed Original ResearchConceptsRacial disparitiesTumor characteristicsEwing sarcomaWhite patientsOsseous neoplasmsAssociated with tumor characteristicsImpact of racial disparitiesNon-Hispanic whitesAssociated with reduced survivalPrimary osseous neoplasmsUtilization of chemotherapyProportion of black patientsFive-year survivalOutcomes of patientsProportion of blacksNon-white patientsCancer RegistryHispanic cohortMedian survivalRare tumorHispanic patientsStudy patientsTumor typesEnd ResultsRace patients
2023
Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology.
Hersh A, Pennington Z, Lubelski D, Elsamadicy A, Dea N, Desai A, Gokaslan Z, Goodwin C, Hsu W, Jallo G, Krishnaney A, Laufer I, Lo S, Macki M, Mehta A, Ozturk A, Shin J, Soliman H, Sciubba D. Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology. Journal Of Neurosurgery Spine 2023, 40: 1-10. PMID: 37856379, DOI: 10.3171/2023.8.spine23190.Peer-Reviewed Original ResearchConceptsIntramedullary spinal cord tumorsSpinal cord tumorsTumor-specific characteristicsOperative candidacyCord tumorsResection strategyNew neurological deficitsGross total resectionT2 signal changeSet of patientsAreas of controversyIMSCT resectionFrail patientsChronic myelopathyChronic paraplegiaNeurological deficitsPreoperative symptomsTranscranial motorDelphi techniqueSurgical managementMild numbnessOperative managementSurgical interventionFurther resectionRare tumorOutcomes Following 2-Level Cervical Interventions with Cage-and-Plate, Zero-Profile, or Arthroplasty Constructs
Khalid S, Mirpuri P, Thomson K, Elsamadicy A, Massaad E, Deysher D, Khilwani H, Adogwa O, Shin J, Mehta A. Outcomes Following 2-Level Cervical Interventions with Cage-and-Plate, Zero-Profile, or Arthroplasty Constructs. World Neurosurgery 2023, 180: e607-e617. PMID: 37797683, DOI: 10.1016/j.wneu.2023.09.117.Peer-Reviewed Original ResearchConceptsAdditional surgeryCervical interventionsPlate constructZero-profileMedical complicationsAnterior cervical proceduresDisc height restorationPostoperative medical complicationsOutcomes of patientsCervical disc diseaseLogistic regression modelsCervical proceduresSecondary outcomesSurgical complicationsIndex interventionPrimary outcomeIndex procedureHeight restorationDisc diseasePatientsSurgeryArthroplastyMotion limitationArtificial discComplicationsAcademic career progression in AANS/CNS Spine Section award recipients
Elsamadicy A, Sherman J, Craft S, Virk M, Elder B, Bonfield C, Snyder L, Ray W, Jones K, Ryu W. Academic career progression in AANS/CNS Spine Section award recipients. Journal Of Neurosurgery Spine 2023, 1-8. DOI: 10.3171/2023.7.spine23259.Peer-Reviewed Original ResearchConceptsAcademic medical centerPeer-reviewed journalsMedical CenterPeer-reviewed publicationsMean numberPrincipal investigatorMean h-indexAANS/CNS SectionNational InstituteFederal research fundingPeripheral nervesCNS SectionSpine surgeryOutstanding abstractsPrior recipientsMedical Research ProgramSubspecialty focusHealth fundingRecipientsAppointment statusNeurological SurgeonsPublication rateOne-thirdFaculty appointmentsProgressionAssessment of the impact of frailty on adverse surgical outcomes in patients undergoing surgery for intracranial tumors using modified frailty index: A systematic review and meta-analysis
Aghajanian S, Shafiee A, Ahmadi A, Elsamadicy A. Assessment of the impact of frailty on adverse surgical outcomes in patients undergoing surgery for intracranial tumors using modified frailty index: A systematic review and meta-analysis. Journal Of Clinical Neuroscience 2023, 114: 120-128. PMID: 37390775, DOI: 10.1016/j.jocn.2023.06.013.Peer-Reviewed Original ResearchConceptsImpact of frailtyFrailty indexMFI scoreAdverse outcomesReoperation rateIntracranial tumorsNon-frail participantsAdverse surgical outcomesNeuro-oncological surgeryWeb of SciencePerioperative outcomesComplication rateIndependent predictorsSurgical outcomesWorse prognosisMean ageObservational studySurgical pathologyMixed-effects multilevel modelsPrimary analysisSystematic reviewNeurosurgical proceduresFrailtySurgical operationSurgeryNovel Standalone Motion-Sparing Pelvic Fixation Prevents Short-Term Insufficiency Fractures After Midsacrectomies Without Sacrificing Normal, Mobile Lumbar Segments Traditionally Used for Stabilization
Lo S, Pieters T, Hersh A, Green R, Suk I, Pennington Z, Elsamadicy A, Sciubba D. Novel Standalone Motion-Sparing Pelvic Fixation Prevents Short-Term Insufficiency Fractures After Midsacrectomies Without Sacrificing Normal, Mobile Lumbar Segments Traditionally Used for Stabilization. Operative Neurosurgery 2023, 25: 278-284. PMID: 37278692, DOI: 10.1227/ons.0000000000000767.Peer-Reviewed Original ResearchConceptsSacral insufficiency fracturesMobile lumbar segmentsInsufficiency fracturesPelvic fixationPartial sacrectomyLumbar segmentsMedian age 59 yearsPrimary malignant bone tumorAge 59 yearsTreatment of choiceMalignant bone tumorsComprehensive cancer centerRetrospective data setConcomitant placementAdverse eventsOverall survivalPrimary outcomeSacral tumorsHistorical cohortMobile spineRetrospective studyCancer CenterLumbopelvic fixationOperative characteristicsBone tumorsSocioeconomic and Racial/Ethnic Disparities in Perception of Health Status and Literacy in Spine Oncological Patients
Elsamadicy A, Wang C, Reeves B, Sherman J, Craft S, Rajjoub R, Koo A, Hersh A, Pennington Z, Lo S, Shin J, Mendel E, Sciubba D. Socioeconomic and Racial/Ethnic Disparities in Perception of Health Status and Literacy in Spine Oncological Patients. Spine 2023, 48: 1107-1115. PMID: 37163649, DOI: 10.1097/brs.0000000000004712.Peer-Reviewed Original ResearchConceptsNon-White HispanicsOncology patientsHigh response rateWhite/CaucasianHealth statusHealth literacyWC patientsResponse rateICD-9/10-CM codesOwn general healthSocioeconomic statusBaseline health statusRacial/Ethnic DisparitiesCross-sectional studyRace/ethnicityExcellent/Severe fatigueGeneral healthOncological patientsBACKGROUND DATADisease processHealthcare costsPatientsMedical careEthnic disparitiesEffects of delayed ambulation following posterior spinal fusion for adolescent idiopathic scoliosis: a single institutional study
Hengartner A, David W, Reeves B, Craft S, Boroumand S, Clappier M, Hansen J, Fernandez T, Koo A, Tuason D, DiLuna M, Elsamadicy A. Effects of delayed ambulation following posterior spinal fusion for adolescent idiopathic scoliosis: a single institutional study. Spine Deformity 2023, 11: 1127-1136. PMID: 37093449, DOI: 10.1007/s43390-023-00693-y.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionAdolescent idiopathic scoliosisSpinal fusionPostoperative complicationsRisk factorsIdiopathic scoliosisMultivariate stepwise logistic regressionOral pain medicationTotal hospital lengthTwenty-nine patientsMethodsThe medical recordsSingle institutional studyStepwise logistic regressionMajor academic institutionHospital lengthHospital stayNine patientsPain medicationUnplanned readmissionIntraoperative variablesPatient demographicsPostoperative outcomesRBC transfusionHealthcare utilizationOperative timeImpact of insurance status on healthcare resource utilization and outcomes in adolescent patients presenting with spinal cord injuries.
Sandhu M, David W, Reeves B, Sherman J, Craft S, Jayaraj C, Boroumand S, Clappier M, Gutierrez A, Sarkozy M, Koo A, Tuason D, DiLuna M, Elsamadicy A. Impact of insurance status on healthcare resource utilization and outcomes in adolescent patients presenting with spinal cord injuries. Journal Of Neurosurgery Pediatrics 2023, 32: 294-301. PMID: 37021755, DOI: 10.3171/2023.2.peds22506.Peer-Reviewed Original ResearchConceptsSpinal cord injuryHospital adverse eventsHealthcare resource utilizationAdverse eventsInsurance statusAdolescent patientsGovernmental insuranceInsurance cohortCord injuryNon-Hispanic white patientsNational Trauma Data BankPrivate insuranceThoracic spinal cord injuryPrivate insurance cohortAdministrative database studyTrauma Data BankClinical Modification codingMultivariate regression analysisPI cohortMedian LOSAdult patientsDischarge dispositionPatient demographicsSCI patientsWhite patientsDifferences in Outcomes and Health Care Resource Utilization After Surgical Intervention for Metastatic Spinal Column Tumor in Safety-Net Hospitals
Elsamadicy A, Koo A, David W, Reeves B, Sherman J, Craft S, Hersh A, Duvall J, Lo S, Shin J, Mendel E, Sciubba D. Differences in Outcomes and Health Care Resource Utilization After Surgical Intervention for Metastatic Spinal Column Tumor in Safety-Net Hospitals. Spine 2023, 48: 800-809. PMID: 36972069, DOI: 10.1097/brs.0000000000004643.Peer-Reviewed Original ResearchConceptsSpinal column tumorsSNH statusPostoperative complicationsDischarge dispositionMultivariable analysisTumor surgeryMetastatic spinal tumor surgeryHealth care resource utilizationNationwide Inpatient Sample databaseICD-10-CM codingNonroutine discharge dispositionObservational cohort studySpinal tumor surgerySafety-net hospitalNonroutine dischargeSNH patientsHospital lengthStudy patientsAdult patientsCohort studyIntraoperative variablesExtended LOSIndependent predictorsLonger LOSProlonged hospitalizationPromoting diversity in neurosurgery through a virtual symposium.
Charles A, Seas A, Corley J, Duvall J, Owolo E, Abu-Bonsrah N, Elsamadicy A, Simpson V, Sanusi O, Holly L, Rodriguez A, Nduom E, Levi A, Liau L, Quiñones-Hinojosa A, Karikari I, Grant G, Fuller A, Goodwin C. Promoting diversity in neurosurgery through a virtual symposium. Journal Of Neurosurgery 2023, 139: 1101-1108. PMID: 36905659, DOI: 10.3171/2023.1.jns221743.Peer-Reviewed Original ResearchMultiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts
Kundishora A, Allington G, McGee S, Mekbib K, Gainullin V, Timberlake A, Nelson-Williams C, Kiziltug E, Smith H, Ocken J, Shohfi J, Allocco A, Duy P, Elsamadicy A, Dong W, Zhao S, Wang Y, Qureshi H, DiLuna M, Mane S, Tikhonova I, Fu P, Castaldi C, López-Giráldez F, Knight J, Furey C, Carter B, Haider S, Moreno-De-Luca A, Alper S, Gunel M, Millan F, Lifton R, Torene R, Jin S, Kahle K. Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts. Nature Medicine 2023, 29: 667-678. PMID: 36879130, DOI: 10.1038/s41591-023-02238-2.Peer-Reviewed Original ResearchConceptsArachnoid cystCerebral arachnoid cystsDe novo variantsAC pathogenesisDevelopmental brain lesionsStructural brain diseaseAppropriate clinical contextPatients' medical recordsDamaging de novo variantsMedical recordsClinical severityBrain lesionsHealthy individualsAC subtypesBrain diseasesGenetic testingNeurodevelopmental pathologyClinical contextPathogenesisPatient phenotypesNeurodevelopmental programsNovo variantsRNA sequencing transcriptomeHuman brainCystsPrevalence and Influence of Frailty on Hospital Outcomes After Surgical Resection of Spinal Meningiomas
Elsamadicy A, Koo A, Reeves B, Craft S, Sayeed S, Sherman J, Sarkozy M, Aurich L, Fernandez T, Lo S, Shin J, Sciubba D, Mendel E. Prevalence and Influence of Frailty on Hospital Outcomes After Surgical Resection of Spinal Meningiomas. World Neurosurgery 2023, 173: e121-e131. PMID: 36773810, DOI: 10.1016/j.wneu.2023.02.019.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreLength of stayHealth care resource utilizationSpinal meningiomasNonroutine dischargeAdverse eventsDischarge dispositionInternational ClassificationExtended LOSMean LOSNational Inpatient Sample databaseFrailty Risk ScoreInfluence of frailtyImpact of frailtyRetrospective cohort studyPerioperative adverse eventsTenth Revision codesClinical Modification codesCost of admissionMultivariate regression analysisHospital outcomesPatient frailtyAdult patientsCohort studyPatient demographicsEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patientsA current review of spinal meningiomas: epidemiology, clinical presentation and management
Elsamadicy A, Reeves B, Craft S, Sherman J, Koo A, Sayeed S, Sarkozy M, Kolb L, Lo S, Shin J, Sciubba D, Mendel E. A current review of spinal meningiomas: epidemiology, clinical presentation and management. Journal Of Neuro-Oncology 2023, 161: 395-404. PMID: 36637710, DOI: 10.1007/s11060-023-04238-1.Peer-Reviewed Original ResearchConceptsSpinal meningiomasClinical presentationTumor developmentAdverse postoperative outcomesBenign spinal tumorsBenign spine tumorsRecent treatment recommendationsCharacteristic imaging findingsSubsequent tumor developmentPostoperative outcomesReceptor statusSpine tumorsImaging findingsSpinal tumorsCase reportTreatment recommendationsClinical evaluationClinical trialsGoogle Scholar searchOperative techniqueIntracranial meningiomasRadiation modalitiesSystematic reviewMeningiomasTumor geneticsIn Reply to the Letter to Editor Regarding "Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus"
Koo A, Elsamadicy A, Matouk C. In Reply to the Letter to Editor Regarding "Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus". World Neurosurgery 2023, 169: 124. PMID: 36585096, DOI: 10.1016/j.wneu.2022.11.023.Peer-Reviewed Original Research
2022
Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity
Elsamadicy A, Sandhu M, Reeves B, Sherman J, Craft S, Williams M, Shin J, Sciubba D. Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity. Clinical Neurology And Neurosurgery 2022, 224: 107532. PMID: 36436433, DOI: 10.1016/j.clineuro.2022.107532.Peer-Reviewed Original ResearchConceptsNon-routine dischargeHealthcare resource utilizationAdverse eventsGeriatric cohortMME useGeriatric patientsSpinal fusionSpine deformityMultivariate logistic regression analysisInpatient narcotic consumptionInpatient opioid consumptionInpatient opioid usePremier Healthcare DatabasePoor surgical outcomesPatient risk stratificationPosterior spinal fusionAdult spinal deformityAdult spine deformityICD-10-CM codesGreater proportionLogistic regression analysisGreater resource utilizationNon-Hispanic whitesOlder CohortOpioid consumptionAssociation of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity
Elsamadicy A, Sandhu M, Reeves B, Freedman I, Koo A, Jayaraj C, Hengartner A, Havlik J, Hersh A, Pennington Z, Lo S, Shin J, Mendel E, Sciubba D. Association of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity. Spine Deformity 2022, 11: 439-453. PMID: 36350557, DOI: 10.1007/s43390-022-00609-2.Peer-Reviewed Original ResearchConceptsAdult spinal deformityInpatient opioid useProportion of patientsOpioid useAdverse eventsHigher MMESpinal fusionHospital costsMME consumptionPostoperative outcomesDischarge dispositionHospital admissionRisk factorsMultivariate analysisLong-term opioid useMethodsA retrospective cohort studyHigh opioid useInpatient opioid consumptionOpioid-related disordersPremier Healthcare DatabasePostoperative adverse eventsPostoperative opioid useRetrospective cohort studyHealthcare resource utilizationNon-routine discharge