2024
Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Dietz N, Kumar C, Elsamadicy A, Bjurström M, Wong K, Jamieson A, Sharma M, Wang D, Ugiliweneza B, Drazin D, Boakye M. Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up. Scientific Reports 2024, 14: 25340. PMID: 39455709, PMCID: PMC11511981, DOI: 10.1038/s41598-024-76248-6.Peer-Reviewed Original ResearchConceptsDegenerative lumbar pathologySurgical site infectionSpinal surgeryPolypharmacy groupSite infectionLumbar pathologyFollow-upMedical complicationsElective lumbar spinal surgeryLumbar spinal surgeryUrinary tract infectionDegenerative lumbar conditionsReturn to the emergency departmentTract infectionsNon-polypharmacy groupSurgical patientsLumbar conditionsSurgeryPatientsComplicationsPolypharmacyEmergency departmentPrescribed medicationsMarketScan datasetDegenerative conditionsThe Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion
Mirpuri P, Khalid S, Colliander R, King P, Tao X, Elsamadicy A, Mehta A, Adogwa O. The Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion. World Neurosurgery 2024, 190: e121-e128. PMID: 39002778, DOI: 10.1016/j.wneu.2024.07.050.Peer-Reviewed Original ResearchTransforaminal lumbar interbody fusionCSF leakSurgical complicationsComplication rateIncidence of CSF leakRate of CSF leakSecondary outcomesRate of surgical complicationsSurgical complication ratePostoperative surgical complicationsSurgical site infectionDay of surgeryLumbar interbody fusionPostoperative complicationsSite infectionWound disruptionPostoperative rateAdult patientsLumbar fusionInterbody fusionIncreased riskPrimary outcomePatientsSurgeryPrimary analysisImpact of Depression on Postoperative Medical and Surgical Outcomes in Spine Surgeries: A Systematic Review and Meta-Analysis
Aghajanian S, Shafiee A, Athar M, Mohammadifard F, Goodarzi S, Esmailpur F, Elsamadicy A. Impact of Depression on Postoperative Medical and Surgical Outcomes in Spine Surgeries: A Systematic Review and Meta-Analysis. Journal Of Clinical Medicine 2024, 13: 3247. PMID: 38892958, PMCID: PMC11172961, DOI: 10.3390/jcm13113247.Peer-Reviewed Original ResearchNon-routine dischargeSpine surgerySurgical complicationsSurgical outcomesStatistically significant higher rateUrinary tract infectionSurgical site infectionDeep vein thrombosisLength of hospitalizationSystematic reviewNon-depressed controlsSignificantly higher ratesUrinary retentionPostoperative medicationTract infectionsPostoperative outcomesPulmonary embolismSite infectionSpinal surgeryVein thrombosisImpact of depressionPooled analysisDepressed patientsHematoma formationHospital length
2023
Associated Risk Factors for Extended Operative Time Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database
Serrato P, Hengartner A, Sayeed S, Prassinos A, Alperovich M, DiLuna M, Elsamadicy A. Associated Risk Factors for Extended Operative Time Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database. Journal Of Craniofacial Surgery 2023, 35: 427-431. PMID: 38078913, DOI: 10.1097/scs.0000000000009920.Peer-Reviewed Original ResearchExtended operative timeCranial vault remodelingRetrospective cohort studyAdverse eventsCohort studyIndependent predictorsPediatric patientsOperative timeRisk factorsVault remodelingNational Surgical Quality Improvement Program-PediatricHealth care resource utilizationPostoperative surgical site infectionSurgeons National Surgical Quality Improvement Program-PediatricMultivariate logistic regression analysisDiseases 9/10 codesNSQIP-Pediatric databasePostoperative adverse eventsHigher American SocietySurgical site infectionAssociated risk factorsSurgical adverse eventsLength of stayLogistic regression analysisNon-Hispanic whites
2021
A Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases
Hersh AM, Feghali J, Hung B, Pennington Z, Schilling A, Antar A, Patel J, Ehresman J, Cottrill E, Lubelski D, Elsamadicy AA, Goodwin CR, Lo SL, Sciubba DM. A Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases. World Neurosurgery 2021, 155: e218-e228. PMID: 34403800, DOI: 10.1016/j.wneu.2021.08.041.Peer-Reviewed Original ResearchConceptsLow platelet countWound complicationsPlatelet countUnplanned reoperationWound infectionRevision surgeryWeb-based calculatorIncision lengthHigher CCIHigher Charlson comorbidity indexSingle comprehensive cancer centerKarnofsky Performance Scale scoreLonger incision lengthCharlson Comorbidity IndexWound-related complicationsIndependent predictive factorsSurgical site infectionMultivariable logistic regressionPerformance Scale scoreComprehensive cancer centerOptimism-corrected areaPoor health statusComorbidity indexIndex surgeryMetastasis surgery
2018
The use of subfascial drains after multi-level anterior cervical discectomy and fusion: does the data support its use?
Adogwa O, Khalid SI, Elsamadicy AA, Voung VD, Lilly DT, Desai SA, Sergesketter AR, Cheng J, Karikari IO. The use of subfascial drains after multi-level anterior cervical discectomy and fusion: does the data support its use? Journal Of Spine Surgery 2018, 4: 227-232. PMID: 30069511, PMCID: PMC6046311, DOI: 10.21037/jss.2018.05.10.Peer-Reviewed Original ResearchSurgical site infectionMulti-level anterior cervical discectomyAnterior cervical discectomySubfascial drainsDrain useHematoma formationACDF proceduresHospital stayCervical discectomyComparison cohortBlood transfusionDecreased incidenceDirect medical record reviewPost-operative blood transfusionDegenerative cervical stenosisMulti-level ACDFAllogenic blood transfusionPercent of patientsConsecutive adult patientsMedical record reviewPost-operative hematomaTime of surgeryCervical stenosisMultilevel ACDFAdult patientsPost-operative drain use in patients undergoing decompression and fusion: incidence of complications and symptomatic hematoma
Adogwa O, Elsamadicy AA, Sergesketter AR, Shammas RL, Vatsia S, Vuong VD, Khalid S, Cheng J, Bagley CA, Karikari IO. Post-operative drain use in patients undergoing decompression and fusion: incidence of complications and symptomatic hematoma. Journal Of Spine Surgery 2018, 4: 220-226. PMID: 30069510, PMCID: PMC6046317, DOI: 10.21037/jss.2018.05.09.Peer-Reviewed Original ResearchSurgical site infectionPost-operative complicationsBody mass indexHematoma formationSpinal decompressionPatient demographicsSubfascial drainsPost-operative complication rateSuperficial surgical site infectionAdult spinal deformity patientsPostoperative complication profilePost-operative drainIncidence of complicationsHospital readmission ratesSpinal deformity patientsMajor academic institutionSymptomatic hematomaHospital stayReadmission ratesComplication rateDrain usePrimary outcomeSite infectionOperative timeUse cohortDoes Nasal Carriage of Staphylococcus aureus Increase the Risk of Postoperative Infections After Elective Spine Surgery: Do Most Infections Occur in Carriers?
Adogwa O, Vuong VD, Elsamadicy AA, Lilly DT, Desai SA, Khalid S, Cheng J, Bagley CA. Does Nasal Carriage of Staphylococcus aureus Increase the Risk of Postoperative Infections After Elective Spine Surgery: Do Most Infections Occur in Carriers? World Neurosurgery 2018, 116: e519-e524. PMID: 29772370, DOI: 10.1016/j.wneu.2018.05.025.Peer-Reviewed Original ResearchConceptsSurgical site infectionElective spine surgeryWound infectionNasal colonizationSite infectionSpine surgeryCases of SSIPost-operative surgical site infectionDirect medical record reviewAdult spinal deformity surgeryProspective multi-institutional studyLocal vancomycin powderPostoperative wound infectionDeep wound infectionHistory of diabetesMajority of patientsMedical record reviewDay of surgeryBody mass indexStandard deviation agePost-operative infectionSpinal deformity surgeryMulti-institutional studyBaseline characteristicsNasal carriage
2017
Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases.
Adogwa O, Elsamadicy AA, Sergesketter A, Vuong VD, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases. Journal Of Neurosurgery Spine 2017, 27: 328-334. PMID: 28665245, DOI: 10.3171/2017.2.spine161310.Peer-Reviewed Original ResearchConceptsSurgical site infectionMean body mass indexIntraoperative vancomycin powderVancomycin powderWound infectionAdult patientsProphylactic useCases of SSIPatients' mean body mass indexMicrobiological patternDirect medical record reviewPostoperative surgical site infectionDuke University Medical CenterDeep wound infectionEmpirical antibiotic therapyHistory of diabetesAdverse clinical outcomesMedical record reviewConsecutive surgical casesDay of surgeryBody mass indexSpinal deformity surgeryUniversity Medical CenterRandomized control trialHealth care systemDepression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery.
Elsamadicy AA, Adogwa O, Lydon E, Sergesketter A, Kaakati R, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Depression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery. Journal Of Neurosurgery Spine 2017, 27: 209-214. PMID: 28574333, DOI: 10.3171/2017.4.spine161012.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAge FactorsComorbidityDecompression, SurgicalDeliriumDepressionElective Surgical ProceduresFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOperative TimePostoperative ComplicationsPrognosisRetrospective StudiesRisk FactorsSpinal CurvaturesSpinal FusionSpineConceptsElective spine surgeryMultivariate logistic regression analysisPostoperative deliriumIndependent risk factorPostoperative complication rateSpine surgeryLogistic regression analysisPatient demographicsComplication rateIndependent predictorsDeformity patientsRisk factorsDepression groupAffective disordersSuperficial surgical site infectionSignificant between-group differencesInferior surgical outcomesPostoperative delirium rateResults Patient demographicsInitial hospital stayProportion of patientsRate of complicationsSurgical site infectionUrinary tract infectionDeep vein thrombosisPost-operative delirium is an independent predictor of 30-day hospital readmission after spine surgery in the elderly (≥65years old): A study of 453 consecutive elderly spine surgery patients
Elsamadicy AA, Wang TY, Back AG, Lydon E, Reddy GB, Karikari IO, Gottfried ON. Post-operative delirium is an independent predictor of 30-day hospital readmission after spine surgery in the elderly (≥65years old): A study of 453 consecutive elderly spine surgery patients. Journal Of Clinical Neuroscience 2017, 41: 128-131. PMID: 28262398, DOI: 10.1016/j.jocn.2017.02.040.Peer-Reviewed Original ResearchConceptsPost-operative deliriumIndependent risk factorSpine surgeryElderly patientsReadmission ratesHospital readmissionRisk factorsDelirium patientsComplication rateIndependent predictorsPost-operative complication rateSuperficial surgical site infectionMultivariate logistic regression analysisDuke University Medical CenterConsecutive elderly patientsSpine surgery patientsSurgical site infectionLogistic regression analysisUniversity Medical CenterLower healthcare costsDSM-V criteriaHospital stayUnplanned readmissionPatient demographicsSurgery patients
2016
Impact of Intraoperative Steroids on Postoperative Infection Rates and Length of Hospital Stay: A Study of 1200 Spine Surgery Patients
Elsamadicy AA, Wang TY, Back AG, Sergesketter A, Warwick H, Karikari IO, Gottfried ON. Impact of Intraoperative Steroids on Postoperative Infection Rates and Length of Hospital Stay: A Study of 1200 Spine Surgery Patients. World Neurosurgery 2016, 96: 429-433. PMID: 27667578, DOI: 10.1016/j.wneu.2016.09.057.Peer-Reviewed Original ResearchConceptsIntraoperative steroidsHospital staySpine surgeryInfection ratePostoperative complicationsPatient demographicsUse cohortSteroid useLong-term steroid useSuperficial surgical site infectionDuke University Medical CenterIntraoperative steroid useSpine surgery patientsPostoperative complication ratePostoperative infection rateShorter hospital staySurgical site infectionUrinary tract infectionUniversity Medical CenterLength of operationLower ratesLow infection rateAdult patientsComplication rateSurgery patients