2024
Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis
Aghajanian S, Mohammadifard F, Kohandel Gargari O, Naeimi A, Bahadorimonfared A, Elsamadicy A. Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis. Neurosurgical Review 2024, 47: 177. PMID: 38644447, DOI: 10.1007/s10143-024-02424-x.Peer-Reviewed Original ResearchConceptsNetwork meta-analysisRate of complicationsBlood lossSpine surgeryEpsilon-aminocaproic acidMeta-analysisTranexamic acidEfficacy of antifibrinolyticsPediatric spine surgeryPerioperative blood lossReduce blood lossStandardized outcome dataRandomized clinical trialsStandard of carePerioperative bleedingTransfusion volumeTransfusion rateAntifibrinolytic agentsMassive transfusionPediatric patientsSafety profilePediatric surgeryProbability of efficacyAntifibrinolyticsClinical trialsIsolated unilateral alar ligamentous injury: illustrative cases
Reeves B, Valcarce-Aspegren M, Robert S, Elsamadicy A, Tucker A, Storm P, DiLuna M, Kundishora A. Isolated unilateral alar ligamentous injury: illustrative cases. Journal Of Neurosurgery Case Lessons 2024, 7: case23664. PMID: 38560931, PMCID: PMC10988229, DOI: 10.3171/case23664.Peer-Reviewed Original ResearchMagnetic resonance imagingCervical collarAdequate first-line treatmentAlar ligament injuryUpper cervical traumaMagnetic resonance imaging evidenceHard cervical collarRigid cervical collarFirst-line treatmentResolution of symptomsRigid external immobilizationNeck painNeck tendernessCervical traumaHalo fixationPediatric patientsDefinitive diagnosisNonsurgical managementCervical radiographsModerate courseFollow-upLigament strainExternal immobilizationOdontoid processPatients
2023
Associated Risk Factors for Extended Operative Time Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database
Serrato P, Hengartner A, Sayeed S, Prassinos A, Alperovich M, DiLuna M, Elsamadicy A. Associated Risk Factors for Extended Operative Time Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database. Journal Of Craniofacial Surgery 2023, 35: 427-431. PMID: 38078913, DOI: 10.1097/scs.0000000000009920.Peer-Reviewed Original ResearchExtended operative timeCranial vault remodelingRetrospective cohort studyAdverse eventsCohort studyIndependent predictorsPediatric patientsOperative timeRisk factorsVault remodelingNational Surgical Quality Improvement Program-PediatricHealth care resource utilizationPostoperative surgical site infectionSurgeons National Surgical Quality Improvement Program-PediatricMultivariate logistic regression analysisDiseases 9/10 codesNSQIP-Pediatric databasePostoperative adverse eventsHigher American SocietySurgical site infectionAssociated risk factorsSurgical adverse eventsLength of stayLogistic regression analysisNon-Hispanic whitesAssociated Risk Factors for Extended Length of Stay Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database
Hengartner A, Serrato P, Sayeed S, Prassinos A, Alperovich M, DiLuna M, Elsamadicy A. Associated Risk Factors for Extended Length of Stay Following Cranial Vault Remodeling for Craniosynostosis: Analysis of the 2012 to 2021 NSQIP-Pediatric Database. Journal Of Craniofacial Surgery 2023, 35: 384-387. PMID: 37943085, DOI: 10.1097/scs.0000000000009847.Peer-Reviewed Original ResearchCranial vault remodelingLOS cohortExtended LOSAdverse eventsPediatric patientsRisk factorsNational Surgical Quality Improvement Program Pediatric databaseVault remodelingSurgeons National Surgical Quality Improvement Program Pediatric databaseNon-Hispanic white patientsHealth care resource utilizationMultivariate logistic regression analysisDiseases 9/10 codesNSQIP-Pediatric databasePostoperative hospital LOSStructural pulmonary abnormalityPostoperative adverse eventsRetrospective cohort studyAssociated risk factorsMultivariate logistic regressionLogistic regression analysisCurrent Procedural TerminologyHospital LOSAnesthesiologists classificationPerioperative complications
2022
134 Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries: Is it Black and White?
Elsamadicy A, Sandhu M, Freedman I, Koo A, Hengartner A, Reeves B, Havlik J, Sarkozy M, Kundishora A, Tuason D, DiLuna M. 134 Racial Disparities in Healthcare Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries: Is it Black and White? Neurosurgery 2022, 68: 39-39. DOI: 10.1227/neu.0000000000001880_134.Peer-Reviewed Original ResearchHealthcare resource utilizationAfrican American patientsMultivariate regression analysisAfrican American cohortHospital complicationsHospital LOSComplication ratePediatric patientsSpinal traumaRacial disparitiesGreater prevalenceLogistic multivariate regression analysisLength of ICUOverall complication rateThoracic spine injuriesAfrican American raceDiagnosis coding systemRegression analysisThoracic spinal injuryPaucity of dataAfrican American/BlackUnited States healthcare systemICU LOSHospital stayInjury presentations
2021
Racial Disparities in Health Care Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries
Elsamadicy AA, Sandhu MR, Freedman IG, Koo AB, Hengartner AC, Reeves BC, Havlik J, Sarkozy M, Hong CS, Kundishora AJ, Tuason DA, DiLuna M. Racial Disparities in Health Care Resource Utilization After Pediatric Cervical and/or Thoracic Spinal Injuries. World Neurosurgery 2021, 156: e307-e318. PMID: 34560297, DOI: 10.1016/j.wneu.2021.09.047.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAsianBlack or African AmericanCervical VertebraeChildChild, PreschoolCohort StudiesFemaleHealth Status DisparitiesHealthcare DisparitiesHispanic or LatinoHumansInfantLength of StayMalePostoperative ComplicationsRetrospective StudiesSocioeconomic FactorsSpinal InjuriesThoracic VertebraeUnited StatesWhite PeopleConceptsHealth care resource utilizationNon-Hispanic blacksNon-Hispanic AsiansHospital complicationsPediatric patientsMultivariate regression analysisNon-Hispanic whitesHospital LOSComplication rateGreater prevalenceICD-10-CM diagnosisLogistic multivariate regression analysisNational Trauma Data BankLonger hospital LOSOverall complication rateThoracic spine injuriesTrauma Data BankRegression analysisThoracic spinal injuryNHB patientsHospital lengthRetrospective cohortSpine injuriesThoracic injuriesRisk ratioPost-traumatic seizures following pediatric traumatic brain injury
Elsamadicy AA, Koo AB, David WB, Lee V, Zogg CK, Kundishora AJ, Hong C, Reeves BC, Sarkozy M, Kahle KT, DiLuna M. Post-traumatic seizures following pediatric traumatic brain injury. Clinical Neurology And Neurosurgery 2021, 203: 106556. PMID: 33636505, DOI: 10.1016/j.clineuro.2021.106556.Peer-Reviewed Original ResearchConceptsLoss of consciousnessTraumatic brain injuryPost-traumatic seizuresSeizure developmentBrain injuryRisk factorsPre-existing medical comorbiditiesPediatric traumatic brain injuryClinical risk factorsDevelopment of seizuresRate of seizuresDecrease healthcare costsEtiology of injuryType of injuryLogistic regression analysisQuality of careHospital complicationsMedical comorbiditiesNeurological complicationsPediatric patientsTBI patientsGreater proportionNinth RevisionSubarachnoid hemorrhageSecondary diagnosis
2020
Impact of Preoperative Anemia on Outcomes After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis
Elsamadicy AA, Freedman IG, Koo AB, David WB, Havlik J, Kundishora AJ, Hong CS, Sciubba DM, Kahle KT, DiLuna M. Impact of Preoperative Anemia on Outcomes After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. World Neurosurgery 2020, 146: e214-e224. PMID: 33091648, DOI: 10.1016/j.wneu.2020.10.074.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionAdolescent idiopathic scoliosisPreoperative anemiaAnemic cohortHospital stayReadmission ratesIndependent predictorsSpinal fusionIdiopathic scoliosisNational Surgical Quality Improvement Program Pediatric databaseSurgeons National Surgical Quality Improvement Program Pediatric databaseUnplanned reoperation rateLonger hospital stayRetrospective cohort studyThirty-day outcomesLonger operative timeLonger lengthPostoperative complicationsReoperation rateCohort studyDischarge dispositionComplication ratePediatric patientsTransfusion eventsOperative timePersistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma
Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. Npj Genomic Medicine 2020, 5: 23. PMID: 32528726, PMCID: PMC7264170, DOI: 10.1038/s41525-020-0130-7.Peer-Reviewed Original ResearchPediatric patientsStandard chemoradiationSTAG2 mutationsTumor clonesPediatric glioblastomaGross total resectionMultiple surgical resectionsTime of recurrenceHigh-grade gliomasDNA damage repair defectsWhole-exome sequencingVariety of treatmentsSurgical resectionNovel deleterious mutationsStandard therapyTotal resectionVaccine therapyClinical evidencePreclinical dataTreatment optionsMultimodal therapyPreclinical studiesClinical settingTherapyAdult counterpartsRisk Factors for the Development of Post-Traumatic Hydrocephalus in Children
Elsamadicy AA, Koo AB, Lee V, David WB, Zogg CK, Kundishora AJ, Hong CS, DeSpenza T, Reeve BC, DiLuna M, Kahle KT. Risk Factors for the Development of Post-Traumatic Hydrocephalus in Children. World Neurosurgery 2020, 141: e105-e111. PMID: 32389871, PMCID: PMC7484270, DOI: 10.1016/j.wneu.2020.04.216.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryRisk factorsBrain injuryNationwide Emergency Department Sample databasePost-traumatic hydrocephalusClinical risk factorsDevelopment of hydrocephalusNeurologic complicationsRespiratory complicationsPediatric patientsHydrocephalus developmentNinth RevisionSubarachnoid hemorrhageEmergency departmentSecondary diagnosisPrimary diagnosisSubdural hemorrhageClinical ModificationInternational ClassificationHydrocephalusHemorrhagePatientsBaseline returnSample databaseAge 6