2016
Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury
Fink KL, Cafferty WB. Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury. Neurotherapeutics 2016, 13: 370-381. PMID: 26846379, PMCID: PMC4824020, DOI: 10.1007/s13311-016-0422-x.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCentral nervous systemMotor pathwaysFunctional recoveryMotor functionMotor circuitsIntact circuitsIncomplete spinal cord injuryPartial spinal cord injuryAdult central nervous systemCorticospinal tract lesionsLimited spontaneous recoveryPermanent functional impairmentSpontaneous functional recoveryExperimental rodent modelsIntrinsic growth capacityRestoration of functionFine motor behaviorRaphespinal tractsDenervated sideTract lesionsCord injuryRubrospinal tractReticulospinal tractCNS neurons
2008
Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function
Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB. Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function. Journal Of Neuroscience 2008, 28: 11998-12009. PMID: 19005065, PMCID: PMC3844838, DOI: 10.1523/jneurosci.3877-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAfferent PathwaysAnimalsChondroitin ABC LyaseChondroitin Sulfate ProteoglycansDisease Models, AnimalMaleNerve RegenerationNeural ConductionNeuronal PlasticityRatsRats, WistarRecovery of FunctionRhizotomySensation DisordersSensory Receptor CellsSpinal CordSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeConceptsSpinal cord injuryFunctional restorationSensory functionSpinal sensory functionsPrimary afferent terminalsVivo electrophysiological recordingsIntact spinal circuitsEnzyme chondroitinase ABCIntrinsic growth potentialAfferent terminalsBehavioral recoveryIntraspinal injectionCord injurySensory deficitsSpinal cordSpinal circuitsAdult ratsMature CNSTherapeutic interventionsExperimental therapeuticsElectrophysiological recordingsAxon growthInjuryIntact pathwaysEnhance function
2005
Regulation of neuropilin 1 by spinal cord injury in adult rats
Agudo M, Robinson M, Cafferty W, Bradbury EJ, Kilkenny C, Hunt SP, McMahon SB. Regulation of neuropilin 1 by spinal cord injury in adult rats. Molecular And Cellular Neuroscience 2005, 28: 475-484. PMID: 15737738, DOI: 10.1016/j.mcn.2004.10.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal hornCord injurySpinal cordAdult ratsAdjacent dorsal root gangliaNeuropilin-1Dorsal root rhizotomyDorsal root gangliaUnilateral rhizotomyMicroglial cellsRoot gangliaSensory projectionsControl animalsRhizotomyWestern blottingBlood vesselsInjuryRT-PCRSuperficial layersCordLesionsRatsSitu hybridizationHorn
2004
Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice
Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice. Journal Of Neuroscience 2004, 24: 4432-4443. PMID: 15128857, PMCID: PMC6729445, DOI: 10.1523/jneurosci.2245-02.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCell DifferentiationCells, CulturedCholera ToxinDisease Models, AnimalDrug SynergismGanglia, SpinalGAP-43 ProteinInterleukin-6MaleMiceMice, KnockoutNerve Growth FactorsNerve RegenerationNeuronsRatsRats, WistarSciatic NerveSciatic NeuropathySpinal CordSpinal Cord InjuriesConceptsDorsal root gangliaInterleukin-6Sensory neuronsConditioning injuryDorsal columnsIntact dorsal root gangliaSoluble IL-6 receptorHost CNS tissueAdult sensory neuronsIL-6 upregulationDorsal column axonsDorsal column afferentsExogenous IL-6Cytokine interleukin-6IL-6 receptorGrowth-associated protein GAP43Neurite extensionConditioning lesionChondroitin sulfate proteoglycanNT-3Myelin inhibitorsDRG cellsRoot gangliaSciatic nerveInjury site
2000
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
Kerr B, Cafferty W, Gupta Y, Bacon A, Wynick D, McMahon S, Thompson S. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. European Journal Of Neuroscience 2000, 12: 793-802. PMID: 10762308, DOI: 10.1046/j.1460-9568.2000.00967.x.Peer-Reviewed Original ResearchConceptsPeripheral nerve injuryNerve injuryBehavioral hypersensitivityExogenous galaninNociceptive processingAdult ratsNervous systemSpinal cord dorsal hornMutant miceNociceptive sensory inputsPersistent behavioral hypersensitivityNeuropathic pain behaviorsNeurotransmitter/neuromodulatorGalanin knockout miceCentral nervous systemC-fos expressionEndogenous galaninGalanin levelsNociceptive deficitsWild-type controlsDorsal hornChronic administrationGalanin expressionExcitatory effectsIntrathecal delivery