2021
Retinal waves prime visual motion detection by simulating future optic flow
Ge X, Zhang K, Gribizis A, Hamodi AS, Sabino AM, Crair MC. Retinal waves prime visual motion detection by simulating future optic flow. Science 2021, 373 PMID: 34437090, PMCID: PMC8841103, DOI: 10.1126/science.abd0830.Peer-Reviewed Original ResearchConceptsEye-specific segregationSpontaneous retinal wavesVisual response propertiesSpontaneous retinal activityDirection-selective responsesSuperior colliculus neuronsOptic flow patternsRetinal wavesRetinal activityColliculus neuronsRetinal circuitsSpontaneous activityChronic disruptionVisual motion detectionEye openingTransient windowResponse propertiesOptic flowSensory experienceNeurons
2018
Homeostatic Control of Spontaneous Activity in the Developing Auditory System
Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron 2018, 99: 511-524.e5. PMID: 30077356, PMCID: PMC6100752, DOI: 10.1016/j.neuron.2018.07.004.Peer-Reviewed Original ResearchConceptsSpiral ganglion neuronsSpontaneous activityAuditory systemDirect neuronal excitationGlutamate releaseEnhanced excitabilityGanglion neuronsUnanesthetized miceSynaptic excitationHearing onsetNeuronal excitationTherapeutic approachesMouse modelSpontaneous burstsCongenital formSynchronized activityHair cellsHomeostatic mechanismsNeuronsHomeostatic controlSimilar frequencyCircuit developmentMiceInfluence developmentDeafness
2016
Reconnecting Eye to Brain
Crair MC, Mason CA. Reconnecting Eye to Brain. Journal Of Neuroscience 2016, 36: 10707-10722. PMID: 27798125, PMCID: PMC5083002, DOI: 10.1523/jneurosci.1711-16.2016.Peer-Reviewed Original ResearchConceptsAudacious Goals InitiativeNational Eye InstituteRetinal ganglion cellsSystem regenerationEye InstituteGanglion cellsVisual functionTraumatic injuryVisual system functionNeural regenerationTarget engagementDisease-induced degenerationRegenerative capacityVisual systemAxon guidanceSystem functionSignificant barriersCurrent understandingSatellite meetingInjuryAxonsDegenerationNeuronsBrain
2013
Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factorsCompetition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus
Furman M, Xu HP, Crair MC. Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus. Journal Of Neurophysiology 2013, 110: 1441-1454. PMID: 23741047, PMCID: PMC3763158, DOI: 10.1152/jn.01066.2012.Peer-Reviewed Original ResearchConceptsSuperior colliculusRetinal wavesRetinal inputBrain slice preparationActivity-dependent competitionWT miceRetinofugal axonsSlice preparationSC neuronsTransgenic miceBrain regionsSynaptic strengthSynaptic developmentSynapse developmentMiceNeuronsEye openingFunctional developmentSynapsesColliculusMolecular mechanismsSpecific roleInstructive roleMorphological developmentAxons
2008
State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells
Kurotani T, Yamada K, Yoshimura Y, Crair MC, Komatsu Y. State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells. Neuron 2008, 57: 905-916. PMID: 18367091, PMCID: PMC2880402, DOI: 10.1016/j.neuron.2008.01.030.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsAnimals, NewbornBicucullineDendritesDose-Response Relationship, DrugDose-Response Relationship, RadiationElectric StimulationExcitatory Amino Acid AntagonistsGABA AntagonistsGamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsNeural InhibitionPatch-Clamp TechniquesPyramidal CellsQuinoxalinesRatsRats, Sprague-DawleySpider VenomsVisual CortexConceptsL-type Ca2Slow-wave sleepSomatic inhibitionPyramidal neuronsLayer 5 pyramidal neuronsBidirectional modificationSlow membrane oscillationsRat visual cortexCortical pyramidal neuronsR-type Ca2Neocortical pyramidal cellsBehavioral statesNeuron responsivenessPyramidal cellsDepolarized phaseRepetitive firingVisual cortexReceptor exocytosisChannel activationInhibitionPotentiationNeuronsSleepMembrane oscillationsDepression
2007
Development of Cortical Maps: Perspectives From the Barrel Cortex
Inan M, Crair MC. Development of Cortical Maps: Perspectives From the Barrel Cortex. The Neuroscientist 2007, 13: 49-61. PMID: 17229975, DOI: 10.1177/1073858406296257.Peer-Reviewed Original ResearchConceptsBarrel mapThalamic axonsBarrel cortexBarrel map formationActivity-dependent cuesMolecular cuesSensory afferentsMotor cortexPrimary somatosensoryThalamocortical axonsSomatosensory cortexCortical neuronsSynapse maturationNeuronal activityFunctional maturationVentricular cellsCortical mapsCortexAxonsNeocortical developmentWiring principlesCortical patterningMammalian neocortexNeocortexNeurons
2000
Neurotrophin-4/5 Alters Responses and Blocks the Effect of Monocular Deprivation in Cat Visual Cortex during the Critical Period
Gillespie D, Crair M, Stryker M. Neurotrophin-4/5 Alters Responses and Blocks the Effect of Monocular Deprivation in Cat Visual Cortex during the Critical Period. Journal Of Neuroscience 2000, 20: 9174-9186. PMID: 11124995, PMCID: PMC2412905, DOI: 10.1523/jneurosci.20-24-09174.2000.Peer-Reviewed Original ResearchConceptsDeprived eyeVisual cortexNT-4/5Monocular deprivationCritical periodIntrinsic signal optical imagingEarly postnatal lifeCat visual cortexCortical cellsNT-3Ocular dominancePostnatal lifeAlters responsesVisual stimulationCortexCorrelated activityHr exposureNeural responsesStimulus orientationEyesInfusionNeuronsDeprivationResponsePeriod
1999
The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons
Zhou C, Qiu Y, Pereira F, Crair M, Tsai S, Tsai M. The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons. Neuron 1999, 24: 847-859. PMID: 10624948, DOI: 10.1016/s0896-6273(00)81032-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimetabolitesAxonsBromodeoxyuridineCarbocyaninesCell DeathCell DifferentiationCerebral CortexCOUP Transcription Factor IDNA-Binding ProteinsFluorescent DyesImmunohistochemistryIn Situ HybridizationMaleMiceMutationNeural PathwaysNeuronsReceptors, GlucocorticoidThalamusTranscription FactorsConceptsSubplate neuronsThalamocortical projectionsCortical layer IVLayer IV neuronsCell deathCorticothalamic connectivityAfferent innervationCerebral cortexThalamocortical axonsLayer IVNervous systemExcessive cell deathFactor INeuronal developmentNeuronsNuclear receptorsPremature cell deathInnervationImproper differentiationImportant regulatorOrphan memberDeathCritical roleDifferentiationFailure
1998
The Role of Visual Experience in the Development of Columns in Cat Visual Cortex
Crair M, Gillespie D, Stryker M. The Role of Visual Experience in the Development of Columns in Cat Visual Cortex. Science 1998, 279: 566-570. PMID: 9438851, PMCID: PMC2453000, DOI: 10.1126/science.279.5350.566.Peer-Reviewed Original ResearchConceptsCortical mapsVisual cortexCat visual cortexPrimary visual cortexWeeks of ageTime course parallelContralateral eyeCerebral cortexCortical plasticityCortical neuronsOcular dominanceVisual deprivationPattern visionCortexWeeksEyesVisual experienceCritical periodCourse parallelCatsNeuronsResponse
1997
Relationship between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats
Crair M, Ruthazer E, Gillespie D, Stryker M. Relationship between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats. Neuron 1997, 19: 307-318. PMID: 9292721, DOI: 10.1016/s0896-6273(00)80941-1.Peer-Reviewed Original ResearchConceptsCortical plasticityVisual cortexSame stimulus orientationSingle-unit recordingsStimulus orientationDeprived eyeIntrinsic optical signalsMonocular deprivationOcular dominanceOcular dominance mapsSelective lossOrientation tuningClosed eyesCritical periodCortexEyesNeuronsFunctional mapsBrief periodCompelling evidenceKittensOcular Dominance Peaks at Pinwheel Center Singularities of the Orientation Map in Cat Visual Cortex
Crair M, Ruthazer E, Gillespie D, Stryker M. Ocular Dominance Peaks at Pinwheel Center Singularities of the Orientation Map in Cat Visual Cortex. Journal Of Neurophysiology 1997, 77: 3381-3385. PMID: 9212282, DOI: 10.1152/jn.1997.77.6.3381.Peer-Reviewed Original Research