2023
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly A, Lohani S, Tang L, Coifman R, Crair M, Mishne G, Cardin J, Higley M. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior. Nature Neuroscience 2023, 27: 148-158. PMID: 38036743, PMCID: PMC11316935, DOI: 10.1038/s41593-023-01498-y.Peer-Reviewed Original ResearchConceptsFunctional connectivitySpontaneous behaviorCortical networksCortical network activityTime-varying functional connectivityFunctional magnetic resonanceCerebral cortexAwake miceDynamic functional connectivityAwake animalsNeighboring neuronsPatterned activityDistinct behavioral statesTwo-photon microscopyNeural activityCortical signalsBehavioral statesCortexNetwork activityCortical dynamicsMagnetic resonance
2020
Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex
Wang BS, Bernardez Sarria MS, An X, He M, Alam NM, Prusky GT, Crair MC, Huang ZJ. Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex. Neuron 2020, 109: 502-515.e7. PMID: 33290732, PMCID: PMC7943176, DOI: 10.1016/j.neuron.2020.11.004.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexTranscallosal pathwayVisual fieldDeficient binocular visionGABAergic chandelier cellsBinocular circuitsBinocular visionChandelier cellsRetinal activityTranscallosal projectionsGeniculocortical inputCallosal activityCenter visual fieldBinocular regionCortexMassive apoptosisDevelopmental assemblyCritical periodV1IpsiBlockadePathwayBinocularityMiceSimultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake EMR, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT. Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI. Nature Methods 2020, 17: 1262-1271. PMID: 33139894, PMCID: PMC7704940, DOI: 10.1038/s41592-020-00984-6.Peer-Reviewed Original ResearchConceptsOptical measurementsBrain functionTransgenic murine modelFunctional magnetic resonance imagingMagnetic resonance imagingFluorescent measuresWhole-brain fMRIMurine modelResonance imagingFluorescence Ca2Human brain functionConnectivity strengthBOLD signalBrain activityWidefieldLow frequencyImagingModalitiesTransfer functionMeasurementsCortex
2011
Visual map development depends on the temporal pattern of binocular activity in mice
Zhang J, Ackman JB, Xu HP, Crair MC. Visual map development depends on the temporal pattern of binocular activity in mice. Nature Neuroscience 2011, 15: 298-307. PMID: 22179110, PMCID: PMC3267873, DOI: 10.1038/nn.3007.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornBrain MappingCalciumChannelrhodopsinsCritical Period, PsychologicalFunctional LateralityIn Vitro TechniquesLightLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicNeuronal PlasticityPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsSuperior ColliculiTime FactorsVision, BinocularVisual PathwaysConceptsDorsal lateral geniculate nucleusEye-specific segregationSpontaneous retinal wavesLateral geniculate nucleusPrimary visual cortexMouse visual systemBinocular activityRetinal wavesGeniculate nucleusCircuit refinementSuperior colliculusSpecific temporal featuresVisual cortexBursts of activityDefinitive evidenceVisual systemColliculusBinocularityCortexMiceActivityHow do barrels form in somatosensory cortex?
Li H, Crair MC. How do barrels form in somatosensory cortex? Annals Of The New York Academy Of Sciences 2011, 1225: 119-129. PMID: 21534999, PMCID: PMC4700879, DOI: 10.1111/j.1749-6632.2011.06024.x.Peer-Reviewed Original Research
2007
Development of Cortical Maps: Perspectives From the Barrel Cortex
Inan M, Crair MC. Development of Cortical Maps: Perspectives From the Barrel Cortex. The Neuroscientist 2007, 13: 49-61. PMID: 17229975, DOI: 10.1177/1073858406296257.Peer-Reviewed Original ResearchConceptsBarrel mapThalamic axonsBarrel cortexBarrel map formationActivity-dependent cuesMolecular cuesSensory afferentsMotor cortexPrimary somatosensoryThalamocortical axonsSomatosensory cortexCortical neuronsSynapse maturationNeuronal activityFunctional maturationVentricular cellsCortical mapsCortexAxonsNeocortical developmentWiring principlesCortical patterningMammalian neocortexNeocortexNeurons
2000
Neurotrophin-4/5 Alters Responses and Blocks the Effect of Monocular Deprivation in Cat Visual Cortex during the Critical Period
Gillespie D, Crair M, Stryker M. Neurotrophin-4/5 Alters Responses and Blocks the Effect of Monocular Deprivation in Cat Visual Cortex during the Critical Period. Journal Of Neuroscience 2000, 20: 9174-9186. PMID: 11124995, PMCID: PMC2412905, DOI: 10.1523/jneurosci.20-24-09174.2000.Peer-Reviewed Original ResearchConceptsDeprived eyeVisual cortexNT-4/5Monocular deprivationCritical periodIntrinsic signal optical imagingEarly postnatal lifeCat visual cortexCortical cellsNT-3Ocular dominancePostnatal lifeAlters responsesVisual stimulationCortexCorrelated activityHr exposureNeural responsesStimulus orientationEyesInfusionNeuronsDeprivationResponsePeriodEmergence of ocular dominance columns in cat visual cortex by 2 weeks of age
Crair M, Horton J, Antonini A, Stryker M. Emergence of ocular dominance columns in cat visual cortex by 2 weeks of age. The Journal Of Comparative Neurology 2000, 430: 235-249. PMID: 11135259, PMCID: PMC2412906, DOI: 10.1002/1096-9861(20010205)430:2<235::aid-cne1028>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsOcular dominance columnsCat visual cortexOcular dominance column formationWeeks of ageGeniculocortical projectionsGeniculocortical afferentsVisual cortexGeniculocortical afferent segregationPostnatal day 14Lateral geniculate nucleus inputsArea of cortexPrevious anatomic studiesRetrograde labelingOcular dominance patternsAnatomic correlatesAnatomic studyVisual deprivationTransneuronal labelAfferent segregationDay 14Eye dominanceAfferentsAnatomic dataCortexSecond week
1998
The Role of Visual Experience in the Development of Columns in Cat Visual Cortex
Crair M, Gillespie D, Stryker M. The Role of Visual Experience in the Development of Columns in Cat Visual Cortex. Science 1998, 279: 566-570. PMID: 9438851, PMCID: PMC2453000, DOI: 10.1126/science.279.5350.566.Peer-Reviewed Original ResearchConceptsCortical mapsVisual cortexCat visual cortexPrimary visual cortexWeeks of ageTime course parallelContralateral eyeCerebral cortexCortical plasticityCortical neuronsOcular dominanceVisual deprivationPattern visionCortexWeeksEyesVisual experienceCritical periodCourse parallelCatsNeuronsResponse
1997
Relationship between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats
Crair M, Ruthazer E, Gillespie D, Stryker M. Relationship between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats. Neuron 1997, 19: 307-318. PMID: 9292721, DOI: 10.1016/s0896-6273(00)80941-1.Peer-Reviewed Original ResearchConceptsCortical plasticityVisual cortexSame stimulus orientationSingle-unit recordingsStimulus orientationDeprived eyeIntrinsic optical signalsMonocular deprivationOcular dominanceOcular dominance mapsSelective lossOrientation tuningClosed eyesCritical periodCortexEyesNeuronsFunctional mapsBrief periodCompelling evidenceKittensOcular Dominance Peaks at Pinwheel Center Singularities of the Orientation Map in Cat Visual Cortex
Crair M, Ruthazer E, Gillespie D, Stryker M. Ocular Dominance Peaks at Pinwheel Center Singularities of the Orientation Map in Cat Visual Cortex. Journal Of Neurophysiology 1997, 77: 3381-3385. PMID: 9212282, DOI: 10.1152/jn.1997.77.6.3381.Peer-Reviewed Original ResearchSilent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanism