2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2010
The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N. The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina. Neuron 2010, 65: 503-515. PMID: 20188655, PMCID: PMC3037728, DOI: 10.1016/j.neuron.2010.01.035.Peer-Reviewed Original ResearchConceptsEye-specific segregationCentral nervous systemRetinal ganglion cellsDendritic motilitySynaptic activityActivity-dependent synapse formationPossible retinal originRGC axon projectionImmune proteinsImmune-deficient miceDendritic densityGanglion cellsClass I major histocompatibility complex genesRetinal originNervous systemSynapse formationAxon projectionsMHCI receptorNeural circuitsSynaptic wiringSelective defectMajor histocompatibility complex (MHC) genesMiceRetinaNormal development