2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2004
How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output
Demb JB, Sterling P, Freed MA. How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output. Journal Of Neurophysiology 2004, 92: 2510-2519. PMID: 15175375, DOI: 10.1152/jn.00108.2004.Peer-Reviewed Original ResearchConceptsSynaptic convergenceSpike outputGanglion cellsIntracellular recordingsSynaptic inputsSpike responsesF1 responseRetinal ganglion cellsSpike rateNeuron synaptic inputsPrimary visual cortexExtracellular recordingsVisual cortexPeak depolarizationStimulus frequencyStimulus cycleSynaptic vesiclesStimulus contrastStrong stimulusSynaptic noiseDepolarizationNeuronsParadoxical findingsMembrane potentialSame cells
1999
Motion Opponency in Visual Cortex
Heeger D, Boynton G, Demb J, Seidemann E, Newsome W. Motion Opponency in Visual Cortex. Journal Of Neuroscience 1999, 19: 7162-7174. PMID: 10436069, PMCID: PMC6782843, DOI: 10.1523/jneurosci.19-16-07162.1999.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVisual motion perceptionMotion opponencyMotion perceptionVisual cortexSecondary visual cortical areasHuman MT complexHuman visual cortexDirection-selective signalsVisual cortical areasSensitive brain areasPrimary visual cortexMacaque monkey brainMagnetic resonance imagingPopulations of neuronsMultiunit electrophysiological recordingsBrain activityPerceptual studiesNeuronal correlatesFMRI measurementsArea MTCortical areasBrain areasMonkey brainResonance imagingNeuronal basis of contrast discrimination
Boynton G, Demb J, Glover G, Heeger D. Neuronal basis of contrast discrimination. Vision Research 1999, 39: 257-269. PMID: 10326134, DOI: 10.1016/s0042-6989(98)00113-8.Peer-Reviewed Original ResearchConceptsVisual cortical areasAverage neuronal activityFunctional magnetic resonance imagingFMRI responsesNeuronal activityCortical areasEarly visual cortical areasMagnetic resonance imagingVisual areas V1Contrast increment thresholdsIncrement thresholdsEarly visual cortexNeuronal responsesBrain areasVisual cortexResonance imagingArea V1Neuronal basisPooled activityStimulus intervalStimulus contrastBaseline contrastNeuronal signalsBrain activityHuman brain activity
1998
Functional Magnetic Resonance Imaging of Early Visual Pathways in Dyslexia
Demb J, Boynton G, Heeger D. Functional Magnetic Resonance Imaging of Early Visual Pathways in Dyslexia. Journal Of Neuroscience 1998, 18: 6939-6951. PMID: 9712663, PMCID: PMC6792964, DOI: 10.1523/jneurosci.18-17-06939.1998.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingBrain activityResonance imagingM pathwayReduced brain activityPrimary visual cortexMotion-sensitive areasSpeed discriminationPerceptual thresholdHigher V1Pathway abnormalitiesVisual motion perceptionEarly visual pathwayGroups of dyslexicsVisual cortexVisual pathwayLower perceptual thresholdsExtrastriate areasArea MTMagnocellular pathwayStimulus speedPathway inputEarly visual systemNormal readers
1997
Brain activity in visual cortex predicts individual differences in reading performance
Demb J, Boynton G, Heeger D. Brain activity in visual cortex predicts individual differences in reading performance. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 13363-13366. PMID: 9371851, PMCID: PMC24314, DOI: 10.1073/pnas.94.24.13363.Peer-Reviewed Original ResearchConceptsBrain activityIndividual differencesSpecific visual pathwaysM pathwayCortical visual areasPrimary visual cortexFunctional magnetic resonance imagingMagnetic resonance imagingPathway abnormalitiesVisual cortexVisual pathwayResonance imagingVisual areasMagnocellular pathwayReading abilityPathway inputSignificant correlationReduced activityDyslexicsDyslexiaPathwayStrong relationshipActivityAbnormalitiesCortex