The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3
Hanke-Gogokhia C, Zapadka T, Finkelstein S, Klingeborn M, Maugel T, Singer J, Arshavsky V, Demb J. The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Journal Of Neuroscience 2024, 44: e1379232024. PMID: 38641407, PMCID: PMC11209669, DOI: 10.1523/jneurosci.1379-23.2024.Peer-Reviewed Original ResearchRod ribbon synapsesDynamin-1Photoreceptor ribbon synapsesDynamin isoformsMembrane scissionRibbon synapsesConventional synapsesReduced synaptic vesicle densitySynaptic vesicle recycling processesEndocytosis of synaptic vesiclesRibbon-type active zonesVesicle densityConditional gene knockout approachGene knockout approachSynaptic vesicle densityVesicle endocytosisVesicle cycleDisrupt endocytosisDynaminSpecialized proteinsSynapse integrityEnlarged vesiclesSynaptic vesiclesKnockout approachRod photoreceptors