2021
Vagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions
2020
Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
de Gee J, Tsetsos K, Schwabe L, Urai A, McCormick D, McGinley M, Donner T. Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains. ELife 2020, 9: e54014. PMID: 32543372, PMCID: PMC7297536, DOI: 10.7554/elife.54014.Peer-Reviewed Original ResearchConceptsPhasic arousalArousal systemMemory-based decisionsSound detection taskDecision-relevant evidenceBrain arousal systemsChoice biasesChoice biasLiberal biasesDecision domainArousalBehavioral effectsBias suppressionBiasesAmbiguous evidenceRapid dilationSuch decisionsMemoryPupilsTaskDecisionsHumansEvidenceGeneral principlesBias
2019
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff D, Zagha E, McCarthy E, McCormick D. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex 2019, 30: 421-437. PMID: 31711133, PMCID: PMC7029483, DOI: 10.1093/cercor/bhz206.Peer-Reviewed Original ResearchConceptsVisual detection taskSecondary motor cortexTask performanceTask-related movementsCortical activityMotor cortexDetection taskTask-independent processesOptimal task performanceWidespread cortical activityTask-related changesHead-fixed miceResponse choicesDorsal cortexOrofacial movementsNeural activityTrial variationLick responsesArousal stateTrial variabilityTarget trialsLick rateCortexCortical signalsTrialsDistinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance
Neske G, Nestvogel D, Steffan P, McCormick D. Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance. Journal Of Neuroscience 2019, 39: 10044-10059. PMID: 31672787, PMCID: PMC6978938, DOI: 10.1523/jneurosci.1226-18.2019.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexSensory processingVisual detection performanceCortical neuronal responsesCortical sensory processingWhole-cell recordingsMouse visual systemSensory cortical activityNeuronal membrane potentialArousal levelNeuronal responsivenessFunction of arousalMice increasesNeuronal responsesCortical activityV1 responsesVisual detection taskCortexSensory stimuliSensory responsesLocomotion periodsVisual stimuliBehavioral performanceMembrane potential
2018
The temporal organization of mouse ultrasonic vocalizations
Castellucci G, Calbick D, McCormick D. The temporal organization of mouse ultrasonic vocalizations. PLOS ONE 2018, 13: e0199929. PMID: 30376572, PMCID: PMC6207298, DOI: 10.1371/journal.pone.0199929.Peer-Reviewed Original ResearchConceptsUltrasonic vocalizationsAdult male C57BL/6J miceMale C57BL/6J miceMouse ultrasonic vocalizationsUSV productionC57BL/6J miceMale miceMouse modelRespiratory patternCommon biological mechanismsMiceMale ultrasonic vocalizationsAdults reliesBiological mechanismsRhythmic seriesTemporal organizationVocalization productionAdult malesHuman diseasesSpectrotemporal featuresFirst reportArticulatory patternsMammalian species
2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2010
P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons
Yu Y, Maureira C, Liu X, McCormick D. P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons. Journal Of Neuroscience 2010, 30: 11858-11869. PMID: 20810905, PMCID: PMC2947942, DOI: 10.1523/jneurosci.2651-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentNeuronal excitabilityPyramidal cellsCalcium concentrationPresynaptic terminalsWhole-cell patch-clamp recordingsPrefrontal cortical pyramidal cellsOmega-agatoxin IVAOmega-conotoxin GVIACortical pyramidal cellsPatch-clamp recordingsBaseline calcium concentrationAction potential repolarizationAction potential generationNeocortical axonsVoltage-activated ion channelsCalcium currentCortical axonsSynaptic terminalsCalcium levelsCalcium channelsSynaptic boutonsSuprathreshold depolarizationElectrophysiological propertiesSubthreshold depolarizationSynaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2007
Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generation
2005
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
2004
Slow Adaptation in Fast-Spiking Neurons of Visual Cortex
Descalzo V, Nowak L, Brumberg J, McCormick D, Sanchez-Vives M. Slow Adaptation in Fast-Spiking Neurons of Visual Cortex. Journal Of Neurophysiology 2004, 93: 1111-1118. PMID: 15385594, DOI: 10.1152/jn.00658.2004.Peer-Reviewed Original ResearchConceptsFS neuronsSpike frequency adaptationSlower time courseShort-duration action potentialsTime courseNeuron's functional propertiesPostadaptation periodSlow afterhyperpolarizationCortical slicesNeuron dischargeAfferent inputInhibitory interneuronsVisual cortexAction potentialsNeuronsSlow adaptationPrevious studiesAfterhyperpolarizationInterneuronsExcitabilityCortexDischargeHistamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons
Lee K, Broberger C, Kim U, McCormick D. Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6716-6721. PMID: 15096604, PMCID: PMC404111, DOI: 10.1073/pnas.0400817101.Peer-Reviewed Original ResearchConceptsApplication of histamineGamma-aminobutyric acidPerigeniculate nucleusGABAergic neuronsSingle spike activityMammalian central nervous systemCentral nervous systemHistaminergic actionPerigeniculate neuronsHistaminergic fibersHistaminergic systemHistaminergic receptorsTuberomammillary nucleusIontophoretic applicationPostsynaptic factorsThalamocortical activityInhibitory responsesNeuronal activityThalamic oscillationsNervous systemHistamineMembrane hyperpolarizationSpindle wavesIonotropic receptorsReversal potential
2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neuronsElectrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses
Nowak L, Azouz R, Sanchez-Vives M, Gray C, McCormick D. Electrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses. Journal Of Neurophysiology 2003, 89: 1541-1566. PMID: 12626627, DOI: 10.1152/jn.00580.2002.Peer-Reviewed Original ResearchConceptsAction potentialsElectrophysiological classesCortical neuronsIntrinsic burstingPrimary visual cortical neuronsShort-duration action potentialsCortical neuronal functionSpiny stellate cellsRegular spikingSpiny stellate neuronsVisual cortical neuronsFrequency adaptationCat area 17High-frequency burstsSpike frequency adaptationCH neuronsTonic trainsNonpyramidal cellsIB neuronsRS neuronsStellate neuronsPyramidal cellsArea 17FS neuronsStellate cells
2002
Inhibitory Interactions Between Ferret Thalamic Reticular Neurons
Shu Y, McCormick D. Inhibitory Interactions Between Ferret Thalamic Reticular Neurons. Journal Of Neurophysiology 2002, 87: 2571-2576. PMID: 11976393, DOI: 10.1152/jn.00850.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsNRT neuronsPostsynaptic potentialsThalamocortical activityReceptor-mediated inhibitory postsynaptic potentialsSpontaneous inhibitory postsynaptic potentialsImportant inhibitory inputThalamic excitatory inputsThalamic reticular nucleusInhibitory interactionsThalamic reticular neuronsThalamic relay nucleiAverage reversal potentialLocal inhibitory interactionsThalamocortical functionNRT cellsReceptor antagonistReticular neuronsReticular nucleusExcitatory inputsIntracellular recordingsInhibitory inputsRelay nucleiExtracellular recordingsNeuronsNeuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
2000
Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networksIonic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
Brumberg J, Nowak L, McCormick D. Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons. Journal Of Neuroscience 2000, 20: 4829-4843. PMID: 10864940, PMCID: PMC6772270, DOI: 10.1523/jneurosci.20-13-04829.2000.Peer-Reviewed Original ResearchConceptsLayer II/III pyramidal neuronsHigh-frequency burst dischargesAction potential generationAction potentialsPyramidal neuronsCortical neuronsBurst dischargesHigh-frequency burst firingVisual cortical slicesAction potential burstsFirst action potentialBurst-firing modeHigh-frequency burstsPotential generationIonic mechanismsIntrinsic burstsCortical slicesLocal cortical networksBurst firingNeocortical neuronsIntracellular recordingsPostsynaptic neuronsATX IIQX-314Single spiking
1999
Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus
von Krosigk M, Monckton J, Reiner P, McCormick D. Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus. Neuroscience 1999, 91: 7-20. PMID: 10336055, DOI: 10.1016/s0306-4522(98)00557-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexElectric StimulationExcitatory Postsynaptic PotentialsFemaleGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGuinea PigsMaleMembrane PotentialsNerve FibersNeuronsReceptors, GABA-AReceptors, GABA-BReceptors, Metabotropic GlutamateReticular FormationRetinaThalamusConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsSlow excitatory postsynaptic potentialMonosynaptic excitatory postsynaptic potentialsDorsal lateral geniculate nucleusGlutamate metabotropic receptorsPostsynaptic potentialsLateral geniculate nucleusThalamocortical neuronsCorticothalamic fibersMetabotropic receptorsGeniculate nucleusRepetitive activationRepetitive stimulationReceptor-mediated inhibitory postsynaptic potentialsGABAergic inhibitory postsynaptic potentialsExcitatory postsynaptic potential amplitudeFrequency-dependent decrementFrequency-dependent depressionAspartate glutamate receptorsPostsynaptic potential amplitudeFrequency-dependent facilitationFrequency-dependent increaseOptic tract fibersCorticothalamic afferents
1998
Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro
Kim U, Mccormick D. Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro. Journal Of Neurophysiology 1998, 80: 1222-1235. PMID: 9744934, DOI: 10.1152/jn.1998.80.3.1222.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnesthetics, LocalAnimalsApaminBicucullineCalciumCalcium Channel BlockersExcitatory Postsynaptic PotentialsFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesLidocaineMaleNeuronsOmega-Conotoxin GVIAPeptidesPeriodicityPotassiumPotassium ChannelsSodiumTetraethylammoniumTetrodotoxinConceptsApplication of apaminSlow afterhyperpolarizationLow-threshold Ca2Perigeniculate neuronsPlateau potentialsBlock of Ca2Spindle wave generationMedium-duration afterhyperpolarizationGABAergic neuronsTonic dischargeFast afterhyperpolarizationPerigeniculate nucleusIntracellular recordingsAfterhyperpolarizationAction potentialsRefractory periodLocal applicationProlonged depolarizationRepetitive Ca2Spindle wavesReversal potentialNeuronsApaminMembrane conductanceActivation