2021
Vagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsArousalCalciumCerebral CortexFemaleMaleMiceNeuronal PlasticityNorepinephrineVagus Nerve StimulationConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions
2020
Neuromodulation of Brain State and Behavior
McCormick D, Nestvogel D, He B. Neuromodulation of Brain State and Behavior. Annual Review Of Neuroscience 2020, 43: 1-25. PMID: 32250724, DOI: 10.1146/annurev-neuro-100219-105424.Peer-Reviewed Original Research
2019
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff D, Zagha E, McCarthy E, McCormick D. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex 2019, 30: 421-437. PMID: 31711133, PMCID: PMC7029483, DOI: 10.1093/cercor/bhz206.Peer-Reviewed Original ResearchConceptsVisual detection taskSecondary motor cortexTask performanceTask-related movementsCortical activityMotor cortexDetection taskTask-independent processesOptimal task performanceWidespread cortical activityTask-related changesHead-fixed miceResponse choicesDorsal cortexOrofacial movementsNeural activityTrial variationLick responsesArousal stateTrial variabilityTarget trialsLick rateCortexCortical signalsTrials
2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2007
Selective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDoses
2006
Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2003
Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons
Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick D. Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons. Journal Of Neuroscience 2003, 23: 10388-10401. PMID: 14614098, PMCID: PMC6741011, DOI: 10.1523/jneurosci.23-32-10388.2003.Peer-Reviewed Original ResearchConceptsSynaptic activityCortical neuronsLayer 5 pyramidal cellsVisual cortical slicesInhibitory synaptic activityOngoing synaptic activityEnhancement of responsivenessAction potential activationBackground synaptic activityExcitatory postsynaptic conductancesSpike-timing precisionInput-output curvesProbability of responseNeuronal responsivenessCortical slicesPyramidal cellsIntracellular recordingsSynaptic inputsSpontaneous periodSynaptic bombardmentSynaptic barragesPostsynaptic conductanceMembrane depolarizationNeuronal processingCortical cellsTurning on and off recurrent balanced cortical activity
Shu Y, Hasenstaub A, McCormick D. Turning on and off recurrent balanced cortical activity. Nature 2003, 423: 288-293. PMID: 12748642, DOI: 10.1038/nature01616.Peer-Reviewed Original ResearchConceptsCerebral cortexLocal cortical circuitsCortical neuronsNeuronal excitabilitySynaptic inputsCortical circuitsSpontaneous activityCortical activitySynaptic connectionsRecurrent excitationCortical organizationCortexNeuronsLocal recurrent connectionsRecurrent activitySelf-sustained activityHypothesized roleInhibitionVast majorityActivityExcitabilityExcitatoryCellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
Compte A, Sanchez-Vives M, McCormick D, Wang X. Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model. Journal Of Neurophysiology 2003, 89: 2707-2725. PMID: 12612051, DOI: 10.1152/jn.00845.2002.Peer-Reviewed Original ResearchConceptsSlow oscillatory activityOscillatory activityUp statesSpontaneous spike dischargeMinority of neuronsSlow-wave sleepStrong recurrent excitationSpike dischargesTonic firingCerebrospinal fluidDown statePharmacological manipulationRecurrent excitationCortical network modelSlow adaptation currentBiophysical network modelInput resistancePhysiological effectsSlow oscillationsPatchy connectionsInhibition blocksVivo dataNeuronsSingle neuron behaviorBath solution
2001
Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons
Lüthi A, Di Paolo G, Cremona O, Daniell L, De Camilli P, McCormick D. Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons. Journal Of Neuroscience 2001, 21: 9101-9111. PMID: 11717343, PMCID: PMC6763888, DOI: 10.1523/jneurosci.21-23-09101.2001.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornCells, CulturedCerebral CortexElectric StimulationExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABA AntagonistsGamma-Aminobutyric AcidMiceNerve Tissue ProteinsNeural InhibitionNeuronsPatch-Clamp TechniquesPhosphatidylinositolsPhosphoric Monoester HydrolasesSodium Channel BlockersSynapsesSynaptic TransmissionSynaptic VesiclesConceptsPaired-pulse depressionHalf-maximal depressionSteady-state depressionSynaptic depressionWhole-cell patch-clamp recordingsSlow depressionInhibitory synaptic responsesPaired-pulse protocolPrimary cortical culturesHigh-frequency stimulationPatch-clamp recordingsBi-exponential time courseUnitary IPSCsGABA releaseGABAergic transmissionCortical culturesPostsynaptic responsesCortical neuronsInhibitory synapsesSynaptic responsesSynaptojanin 1Presynaptic stimulationInhibitory neuronsRelease probabilityStimulation frequency
2000
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives M, McCormick D. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature Neuroscience 2000, 3: 1027-1034. PMID: 11017176, DOI: 10.1038/79848.Peer-Reviewed Original ResearchConceptsSlow-wave sleepLocal cortical circuitsSlow oscillationsFerret neocortexCerebral cortexExtracellular ionic compositionPyramidal neuronsCortical circuitsCortical rhythmsSlow rhythmRecurrent excitationLayer 5NeocortexInhibitory networksExcitatory interactionsBathing mediumExcitatory stateSleepRecurrent activityRhythmCortexNeuronsNetwork mechanismsCorticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
Blumenfeld H, McCormick D. Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks. Journal Of Neuroscience 2000, 20: 5153-5162. PMID: 10864972, PMCID: PMC6772273, DOI: 10.1523/jneurosci.20-13-05153.2000.Peer-Reviewed Original ResearchConceptsParoxysmal oscillationsThalamic burstsReceptor antagonist CGP 35348Corticothalamic tractsSpindle wavesAntagonist CGP 35348Receptor antagonist picrotoxinSlow-wave sleepHz oscillationsHigh-frequency burstsNormal action potentialPerigeniculate neuronsCGP 35348Antagonist picrotoxinSlow IPSPCorticothalamic inputsFast IPSPsThalamocortical neuronsCortical influencesAbsence seizuresBurst firingCortical neuronsCortical firingThalamocortical networkCorticothalamic networks
1999
Are thalamocortical rhythms the rosetta stone of a subset of neurological disorders?
McCormick D. Are thalamocortical rhythms the rosetta stone of a subset of neurological disorders? Nature Medicine 1999, 5: 1349-1351. PMID: 10581069, DOI: 10.1038/70911.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexElectrophysiologyHumansModels, NeurologicalNervous System DiseasesPeriodicityThalamusEssential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
Cremona O, Di Paolo G, Wenk M, Lüthi A, Kim W, Takei K, Daniell L, Nemoto Y, Shears S, Flavell R, McCormick D, De Camilli P. Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling. Cell 1999, 99: 179-188. PMID: 10535736, DOI: 10.1016/s0092-8674(00)81649-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell-Free SystemCerebral CortexCoated Pits, Cell-MembraneEndocytosisEnzyme InhibitorsExonsHippocampusIn Vitro TechniquesMembrane PotentialsMiceMice, KnockoutMicroscopy, ElectronNerve EndingsNerve Tissue ProteinsNeuronsPhosphatidylinositolsPhosphoric Monoester HydrolasesSynaptic VesiclesSpontaneous activity: signal or noise?
McCormick D. Spontaneous activity: signal or noise? Science 1999, 285: 541-3. PMID: 10447487, DOI: 10.1126/science.285.5427.541.Peer-Reviewed Original ResearchModulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulationDynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus
von Krosigk M, Monckton J, Reiner P, McCormick D. Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus. Neuroscience 1999, 91: 7-20. PMID: 10336055, DOI: 10.1016/s0306-4522(98)00557-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexElectric StimulationExcitatory Postsynaptic PotentialsFemaleGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGuinea PigsMaleMembrane PotentialsNerve FibersNeuronsReceptors, GABA-AReceptors, GABA-BReceptors, Metabotropic GlutamateReticular FormationRetinaThalamusConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsSlow excitatory postsynaptic potentialMonosynaptic excitatory postsynaptic potentialsDorsal lateral geniculate nucleusGlutamate metabotropic receptorsPostsynaptic potentialsLateral geniculate nucleusThalamocortical neuronsCorticothalamic fibersMetabotropic receptorsGeniculate nucleusRepetitive activationRepetitive stimulationReceptor-mediated inhibitory postsynaptic potentialsGABAergic inhibitory postsynaptic potentialsExcitatory postsynaptic potential amplitudeFrequency-dependent decrementFrequency-dependent depressionAspartate glutamate receptorsPostsynaptic potential amplitudeFrequency-dependent facilitationFrequency-dependent increaseOptic tract fibersCorticothalamic afferentsChapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges
Destexhe A, McCormick D, Sejnowski T. Chapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges. Progress In Brain Research 1999, 121: 289-307. PMID: 10551033, DOI: 10.1016/s0079-6123(08)63080-0.Peer-Reviewed Original Research
1998
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
Kim U, McCormick D. The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus. Journal Of Neuroscience 1998, 18: 9500-9516. PMID: 9801387, PMCID: PMC6792899, DOI: 10.1523/jneurosci.18-22-09500.1998.Peer-Reviewed Original ResearchConceptsAction potentialsThalamocortical neuronsPostsynaptic neuronsDorsal lateral geniculate nucleus (dLGN) neuronsLateral geniculate nucleus neuronsDual intracellular recordingsTonic firing modesLow-threshold Ca2Single action potentialHigh-frequency burstsAction potential generationPerigeniculate neuronsTonic trainsCell typesMembrane potentialNucleus neuronsBurst dischargesIntracellular recordingsGeneration of Ca2Synaptic transmissionPresynaptic cellTemporal summationEpileptic seizuresSynchronized rhythmic oscillationsSynaptic interactions