2024
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13: rp94167. PMID: 38808733, PMCID: PMC11136495, DOI: 10.7554/elife.94167.Peer-Reviewed Original ResearchConceptsTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsSensory discriminationMouse dorsalCortical areasBehavior primitivesMesoscopic imagingPopulations of neuronsNeural ensemblesLateral neocortexSimultaneous accessImage dataInternal stateNeuron resolutionNeocortexMiceActivation motifNeuronsSpontaneous changesArousalCortexPan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13 DOI: 10.7554/elife.94167.3.Peer-Reviewed Original ResearchTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsIn vivo preparationsSensory discriminationMouse dorsalCortical areasPopulations of neuronsBehavior primitivesNeural ensemblesLateral neocortexMesoscopic imagingSimultaneous accessInternal stateNeuron resolutionImage dataNeocortexMiceActivation motifNeuronsSpontaneous changesArousal
2018
The temporal organization of mouse ultrasonic vocalizations
Castellucci G, Calbick D, McCormick D. The temporal organization of mouse ultrasonic vocalizations. PLOS ONE 2018, 13: e0199929. PMID: 30376572, PMCID: PMC6207298, DOI: 10.1371/journal.pone.0199929.Peer-Reviewed Original ResearchConceptsUltrasonic vocalizationsAdult male C57BL/6J miceMale C57BL/6J miceMouse ultrasonic vocalizationsUSV productionC57BL/6J miceMale miceMouse modelRespiratory patternCommon biological mechanismsMiceMale ultrasonic vocalizationsAdults reliesBiological mechanismsRhythmic seriesTemporal organizationVocalization productionAdult malesHuman diseasesSpectrotemporal featuresFirst reportArticulatory patternsMammalian species
2017
Articulation and timing in mouse ultrasonic vocalizations
Castellucci G, Calbick D, McCormick D. Articulation and timing in mouse ultrasonic vocalizations. The Journal Of The Acoustical Society Of America 2017, 141: 3822-3822. DOI: 10.1121/1.4988478.Peer-Reviewed Original ResearchDifferential temporal structures in mouse ultrasonic vocalizations relay sex and age information about the producer
Calbick D, Castellucci G, McCormick D. Differential temporal structures in mouse ultrasonic vocalizations relay sex and age information about the producer. The Journal Of The Acoustical Society Of America 2017, 141: 3946-3946. DOI: 10.1121/1.4988955.Peer-Reviewed Original Research
2015
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha E, Ge X, McCormick DA. Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output. Neuron 2015, 88: 565-577. PMID: 26593093, PMCID: PMC4660255, DOI: 10.1016/j.neuron.2015.09.044.Peer-Reviewed Original ResearchConceptsPopulations of neuronsAnticipation of movementMotor cortexCortical neuronsCortical circuitsIntracellular techniquesUnit recordingsNeural ensemblesMotor outputNeuronsSensory stimuliNeural activityMotor representationsSensory detection taskMotor commandsFuture studiesTask-related neural dynamicsCortexMiceCellular activitiesCortical Membrane Potential Signature of Optimal States for Sensory Signal Detection
McGinley MJ, David SV, McCormick DA. Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection. Neuron 2015, 87: 179-192. PMID: 26074005, PMCID: PMC4631312, DOI: 10.1016/j.neuron.2015.05.038.Peer-Reviewed Original ResearchConceptsCortical neuronsAuditory cortical neuronsSound-evoked responsesSensory-evoked responsesBackground synaptic activityMembrane potentialTonic periodsSignal detection behaviorSynaptic activityStable hyperpolarizationMembrane potential activitySlow oscillationsHippocampal recordingsNeural correlatesNeuronsTask performanceArousalPotential activityDetection behaviorPhysiological signaturesNoise detection taskArousal measuresMiceActivity
2014
Spectrotemporal alterations and syllable stereotypy in the vocalizations of mouse genetic models of speech-language disorders
Castellucci G, McGinley M, McCormick D. Spectrotemporal alterations and syllable stereotypy in the vocalizations of mouse genetic models of speech-language disorders. The Journal Of The Acoustical Society Of America 2014, 135: 2390-2390. DOI: 10.1121/1.4877904.Peer-Reviewed Original ResearchSpeech-language disordersMouse genetic modelsKnockout miceHeterozygous knockout miceMotor deficitsWildtype littermatesMouse modelSpeech motor deficitsGenetic modelsMiceDisordersLittermatesBiological basisSpecific language impairmentDeficitsDevelopmental dyslexiaLanguage impairmentAdult vocalizationsAuditory cortex membrane potential dynamics in mice during challenging and ethologically relevant natural soundscapes
McGinley M, Castellucci G, McCormick D. Auditory cortex membrane potential dynamics in mice during challenging and ethologically relevant natural soundscapes. The Journal Of The Acoustical Society Of America 2014, 135: 2416-2416. DOI: 10.1121/1.4878018.Peer-Reviewed Original Research