2023
The active zone protein CLA-1 (Clarinet) bridges two subsynaptic domains to regulate presynaptic sorting of ATG-9
Xuan Z, Colón-Ramos D. The active zone protein CLA-1 (Clarinet) bridges two subsynaptic domains to regulate presynaptic sorting of ATG-9. Autophagy 2023, 19: 2807-2808. PMID: 37389488, PMCID: PMC10472863, DOI: 10.1080/15548627.2023.2229227.Peer-Reviewed Original ResearchConceptsATG-9Forward genetic screenAdaptor protein complexesIntegral synaptic vesicle proteinsActive zone proteinsSynaptic vesicle cycleCLA-1Synaptic vesicle proteinsGenetic screenPeriactive zoneAutophagosome biogenesisProtein complexesVesicle cycleVesicle proteinsLong isoformNovel roleSubsynaptic domainsZone proteinNeuronal synapsesSynaptic vesiclesProteinDistinct mechanismsVesiclesMutantsPresynaptic localizationThe active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy
Xuan Z, Yang S, Clark B, Hill S, Manning L, Colón-Ramos D. The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy. PLOS Biology 2023, 21: e3002030. PMID: 37053235, PMCID: PMC10101500, DOI: 10.1371/journal.pbio.3002030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyCaenorhabditis elegansNeuronsPresynaptic TerminalsProtein TransportSynapsesConceptsATG-9Presynaptic autophagyAdaptor protein complexesZone proteinActive zone proteinsC. elegans neuronsSynaptic vesicle proteinsGenetic screenPeriactive zoneAutophagosome biogenesisCellular homeostasisProtein complexesVesicle proteinsGenetic analysisLong isoformNovel roleSynaptic vesiclesAutophagyDistinct mechanismsProteinVesiclesSortingCLA-1Abnormal accumulationActive zone
2013
Synapse Location during Growth Depends on Glia Location
Shao Z, Watanabe S, Christensen R, Jorgensen EM, Colón-Ramos DA. Synapse Location during Growth Depends on Glia Location. Cell 2013, 154: 337-350. PMID: 23870123, PMCID: PMC3808971, DOI: 10.1016/j.cell.2013.06.028.Peer-Reviewed Original ResearchSerotonergic Neurosecretory Synapse Targeting Is Controlled by Netrin-Releasing Guidepost Neurons in Caenorhabditis elegans
Nelson JC, Colón-Ramos DA. Serotonergic Neurosecretory Synapse Targeting Is Controlled by Netrin-Releasing Guidepost Neurons in Caenorhabditis elegans. Journal Of Neuroscience 2013, 33: 1366-1376. PMID: 23345213, PMCID: PMC3584569, DOI: 10.1523/jneurosci.3471-12.2012.Peer-Reviewed Original ResearchConceptsUNC-34/EnabledReceptor UNC-40/DCCUNC-6/NetrinUNC-40/DCCNetrin receptor UNC-40/DCCCaenorhabditis elegansUNC-40NSM neuronsSynapse targetingMolecular linkMolecular mechanismsNovel mechanismSpatial specificitySite targetsRelease sitesNetrinPostsynaptic partnersSite formationRing neuronsSpecific regionsTargetingCaenorhabditisElegansLamellipodinGuidepost neurons
2007
Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans
Colón-Ramos D, Margeta MA, Shen K. Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans. Science 2007, 318: 103-106. PMID: 17916735, PMCID: PMC2741089, DOI: 10.1126/science.1143762.Peer-Reviewed Original Research