2022
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease
Meza R, Ancatén-González C, Chiu C, Chávez A. Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease. Frontiers In Cellular Neuroscience 2022, 16: 864828. PMID: 35518644, PMCID: PMC9062234, DOI: 10.3389/fncel.2022.864828.Peer-Reviewed Original ResearchTransient receptor potential vanilloid 1Synaptic plasticityTRPV1 functionActivity-dependent synaptic changesLigand-gated nonselective cation channelCentral synapsesNonselective cation channelsRegulate synaptic functionVanilloid 1Pain sensationCation channelsHealth and DiseaseSynaptic efficacySynaptic changesBrain regionsPostsynaptic compartmentsNeurotransmitter releasePresynaptic terminalsTherapeutic treatmentSynaptic functionBrain disordersPotential roleSynapsesBrainPain
2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors
2019
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Chiu CQ, Barberis A, Higley MJ. Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nature Reviews Neuroscience 2019, 20: 272-281. PMID: 30837689, DOI: 10.1038/s41583-019-0141-5.Peer-Reviewed Original ResearchConceptsGABAergic synaptic plasticityInhibitory GABAergic synapsesPostsynaptic action potentialsInhibitory synaptic strengthGABAergic synapsesSynaptic excitationLong-term plasticityGlutamatergic signalingNeuronal activitySynaptic plasticityNeuronal circuitsAction potentialsSynaptic strengthIndividual neuronsCellular mechanismsLines of evidenceBody of literaturePlasticityNeuronsFunctional stabilitySynapses
2011
Long-term plasticity at inhibitory synapses
Castillo P, Chiu C, Carroll R. Long-term plasticity at inhibitory synapses. Current Opinion In Neurobiology 2011, 21: 328-338. PMID: 21334194, PMCID: PMC3092861, DOI: 10.1016/j.conb.2011.01.006.Peer-Reviewed Original ResearchConceptsSynaptic plasticityInhibitory synaptic plasticityModification of neural circuitsNeural circuitsNeural circuit refinementNeural circuit functionGABAergic plasticityRegulate excitabilityExcitatory/inhibitory balanceInhibitory plasticityCircuit refinementExcitatory synapsesLong-term plasticitySynaptic efficacyFunctional relevanceCircuit functionDiverse mechanismsLTP/LTDEfficacySynapses
2010
Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses
Chiu C, Castillo P. Endocannabinoid Mediated Long-Term Depression at Inhibitory Synapses. 2010, 149-166. DOI: 10.1007/978-1-4419-6978-1_11.Peer-Reviewed Original ResearchI-LTDLong-term potentiationSynaptic plasticityActivating presynaptic type 1 cannabinoid receptorsHeterosynaptic form of plasticityType 1 cannabinoid receptorInhibitory synapsesGABAergic synaptic plasticityMetabotropic glutamatergic receptorsExcitatory synaptic plasticityBasis of learningECB mobilizationFunction of neural circuitsCellular basis of learningBrain structuresExcitability of neuronsExcitatory glutamatergic synapsesGlutamatergic receptorsExcitatory/inhibitory balanceGABA releaseRetrograde messengerActivity-dependent changesNeural circuitsGABAergic synapsesGlutamatergic synapses
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide