Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat
Gursky ZH, Johansson JR, Klintsova AY. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International Journal Of Developmental Neuroscience 2020, 80: 558-571. PMID: 32681672, PMCID: PMC8246316, DOI: 10.1002/jdn.10051.Peer-Reviewed Original ResearchConceptsPostnatal alcohol exposureEarly postnatal alcohol exposureAlcohol exposureAdolescent exerciseCerebellar volumeMicroglial densityCerebellar microgliaRodent modelsAberrant cerebellar connectivityMicroglia-specific proteinsFetal alcohol spectrum disordersPotential therapeutic effectsDevelopmental alcohol exposurePostnatal day 42Female Long-EvansAlcohol spectrum disordersExercise interventionMicroglial dysfunctionNeuroimmune dysfunctionNeuroimmune cellsNeuroimmune functionVoluntary exerciseTherapeutic effectMicrogliaCerebellar connectivity