2024
Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
Park D, Fujise K, Wu Y, Luján R, Del Olmo-Cabrera S, Wesseling J, De Camilli P. Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2409605121. PMID: 38985768, PMCID: PMC11260120, DOI: 10.1073/pnas.2409605121.Peer-Reviewed Original ResearchConceptsSynaptic vesiclesFamily proteinsBiogenesis of synaptic vesiclesClusters of small vesiclesSize of synaptic vesiclesSynaptogyrin familySynaptogyrin-1Vesicle proteinsSynaptogyrinTransmembrane domainOrganismal levelSmall vesiclesProteinMild defectsVesiclesFamily membersBiogenesisSmall sizeFamilyMiceSynapsinCoexpressionAbundanceSynaptoporinMembers
2015
Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis
Fan F, Ji C, Wu Y, Ferguson SM, Tamarina N, Philipson LH, Lou X. Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis. Journal Of Clinical Investigation 2015, 125: 4026-4041. PMID: 26413867, PMCID: PMC4639984, DOI: 10.1172/jci80652.Peer-Reviewed Original ResearchConceptsDynamin 2Glucose-stimulated insulin secretionΒ-cellsExocytosis-endocytosis couplingControl β-cellsMutant β-cellsCell surface expansionF-actin remodelingInsulin granule exocytosisEndocytic intermediatesMembrane fissionInsulin granule recruitmentPancreatic β-cell dysfunctionPlasma membraneActin filamentsBiphasic insulin secretionInsulin granulesGene ablationΒ-cell dysfunctionGranule recruitmentGlucose homeostasisBlood glucose homeostasisEndocytosisGranule exocytosisEssential role