2012
The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress
Wolyniec K, Levav-Cohen Y, Jiang Y, Haupt S, Haupt Y. The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress. Oncogene 2012, 32: 3510-3519. PMID: 22986523, DOI: 10.1038/onc.2012.365.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCells, CulturedCellular SenescenceHumansMiceOxidative StressReactive Oxygen SpeciesStress, PhysiologicalUbiquitin-Protein LigasesConceptsE3 ubiquitin ligaseReactive oxygen speciesUbiquitin ligaseStress responseCellular responsesE6AP expressionStress conditionsImportant stress conditionsCell growthCellular stress responseAppropriate cellular responsesOxidative stress responseSpecific stress conditionsOxidative stressIntracellular reactive oxygen speciesOncogenic RasCellular senescenceGrowth-suppressive effectsOxidative DNA damageApoptotic responseNovel roleCell deathImportant regulatorE6APDNA damage
2011
E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts
Levav-Cohen Y, Wolyniec K, Alsheich-Bartok O, Chan A, Woods S, Jiang Y, Haupt S, Haupt Y. E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts. Oncogene 2011, 31: 2199-2209. PMID: 21927031, DOI: 10.1038/onc.2011.402.Peer-Reviewed Original ResearchConceptsMouse embryo fibroblastsOncogene-induced senescenceCellular responsesEmbryo fibroblastsCellular stress responseRas-induced senescenceE3 ubiquitin ligaseStress-induced accumulationRole of E6APUbiquitin ligaseProtein regulatorsTissue homeostasisReplicative senescenceCellular senescenceCell cycleStress responseImportant regulatorSenescenceStress conditionsE6APIndependent growthEnhanced growthEnhanced proliferationReplicativeRegulator