Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers
Pappas A, Bey A, Wang X, Rossi M, Kim Y, Yan H, Porkka F, Duffney L, Phillips S, Cao X, Ding J, Rodriguiz R, Yin H, Weinberg R, Ji R, Wetsel W, Jiang Y. Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. JCI Insight 2017, 2: e92052. PMID: 29046483, PMCID: PMC5846902, DOI: 10.1172/jci.insight.92052.Peer-Reviewed Original ResearchAmphetamineAnhedoniaAnimalsAntimanic AgentsBehavior, AnimalBipolar DisorderCentral Nervous System StimulantsChronobiology DisordersCognitive DysfunctionFemaleHippocampusLithium CompoundsMaleMiceMice, KnockoutMotor ActivityN-MethylaspartateNerve Tissue ProteinsPhenotypeProsencephalonReceptors, AMPAReceptors, N-Methyl-D-AspartateSocial Behavior DisordersSynapses