2010
MAG and OMgp Synergize with Nogo-A to Restrict Axonal Growth and Neurological Recovery after Spinal Cord Trauma
Cafferty WB, Duffy P, Huebner E, Strittmatter SM. MAG and OMgp Synergize with Nogo-A to Restrict Axonal Growth and Neurological Recovery after Spinal Cord Trauma. Journal Of Neuroscience 2010, 30: 6825-6837. PMID: 20484625, PMCID: PMC2883258, DOI: 10.1523/jneurosci.6239-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBiotinCells, CulturedDextransDisease Models, AnimalFemaleFunctional LateralityGanglia, SpinalGPI-Linked ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMutationMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNerve Tissue ProteinsNeuronsNogo ProteinsPyramidal TractsReceptors, Cell SurfaceReceptors, SerotoninRecovery of FunctionSpinal Cord InjuriesConceptsAxonal growthSpinal Cord Injury StudyMutant miceGreater axonal growthGreater behavioral recoverySpinal cord traumaWild-type miceAxonal growth inhibitionHeterozygous mutant miceDeficient myelinNeurological recoveryCNS damageTriple-mutant miceBehavioral recoveryCord traumaFunctional recoveryNeurological functionMyelin inhibitorsAxonal regrowthReceptor mechanismsInjury studiesMyelin inhibitionDecoy receptorOptimal chanceMice
2009
Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord
Duffy P, Schmandke A, Schmandke A, Sigworth J, Narumiya S, Cafferty WB, Strittmatter SM. Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord. Journal Of Neuroscience 2009, 29: 15266-15276. PMID: 19955379, PMCID: PMC2855556, DOI: 10.1523/jneurosci.4650-09.2009.Peer-Reviewed Original ResearchMeSH KeywordsAmidesAnalysis of VarianceAnimalsAxonsBehavior, AnimalBrain InjuriesCA1 Region, HippocampalCells, CulturedCholera ToxinEnzyme InhibitorsGanglia, SpinalGene Expression RegulationMedian NeuropathyMiceMice, Inbred C57BLMice, KnockoutMyelin ProteinsNerve RegenerationNeuronsNogo ProteinsPyridinesReceptors, Calcitonin Gene-Related PeptideRhizotomyRho-Associated KinasesSpinal Cord InjuriesTime FactorsVersicansConceptsSpinal cordCNS traumaFunctional recoveryBasso Mouse Scale scoresSpinal Cord Injury StudyAxonal growthDorsal root entry zoneDorsal root ganglion neuronsAdult mouse spinal cordAxonal growth inhibitorsSpinal cord hemisectionRoot entry zoneSpinal cord injuryCaudal spinal cordMouse spinal cordDorsal hemisectionRaphespinal axonsDorsal rhizotomyCrush injuryCord hemisectionCorticospinal axonsChondroitin sulfate proteoglycanCord injuryGanglion neuronsInjury paradigms
2008
Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis
Averill S, Inglis JJ, King VR, Thompson SW, Cafferty WB, Shortland PJ, Hunt SP, Kidd BL, Priestley JV. Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis. Neuroscience 2008, 155: 1227-1236. PMID: 18652880, DOI: 10.1016/j.neuroscience.2008.06.049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalGanglia, SpinalGene ExpressionGlial Cell Line-Derived Neurotrophic FactorIndolesLectinsLeukemia Inhibitory FactorLithostathineMaleNeuronsProto-Oncogene Proteins c-retRatsRats, WistarReceptor, trkAReceptors, Purinergic P2Receptors, Purinergic P2X3Substance PTime FactorsConceptsGlial cell line-derived neurotrophic factorDorsal root ganglion neuronsNerve growth factorDRG neuronsLeukemia inhibitory factorReg-2Ganglion neuronsLectin Griffonia simplicifolia IB4Line-derived neurotrophic factorDRG cell bodiesDorsal horn cellsCentral axon terminalsSchwann cell mitogensGriffonia simplicifolia IB4IB4 populationDorsal hornNerve injuryHorn cellsIntrathecal deliveryNeurotrophic factorSubstance PSympathetic neuronsSpinal cordInduced monoarthritisRat model
2005
Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation
Qiu J, Cafferty WB, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation. Journal Of Neuroscience 2005, 25: 1645-1653. PMID: 15716400, PMCID: PMC6725934, DOI: 10.1523/jneurosci.3269-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAxonsAxotomyCells, CulturedCholera ToxinCytokine Receptor gp130DNA-Binding ProteinsGanglia, SpinalGAP-43 ProteinInfusion Pumps, ImplantableJanus Kinase 2MaleMembrane GlycoproteinsNerve CrushNerve RegenerationNeuritesPhosphorylationProtein Processing, Post-TranslationalProtein-Tyrosine KinasesProto-Oncogene ProteinsRatsRats, WistarSciatic NerveSignal TransductionSpinal Cord InjuriesSTAT3 Transcription FactorTrans-ActivatorsTyrphostinsConceptsSciatic nerve transectionAdult spinal cordSpinal cordSignal transducerConditioning injuryNerve transectionDorsal columnsPerineural infusionAxonal regenerationTranscription 3 (STAT3) activationDorsal root ganglion neuronsTime-dependent phosphorylationProximal nerve stumpSpinal axon regenerationTranscription factorsTranscription 3Peripheral injurySTAT3 activationDRG neuronsNerve stumpInhibitor AG490Ganglion neuronsSciatic nerveGlial scarSTAT3 phosphorylation
2004
Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice
Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice. Journal Of Neuroscience 2004, 24: 4432-4443. PMID: 15128857, PMCID: PMC6729445, DOI: 10.1523/jneurosci.2245-02.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCell DifferentiationCells, CulturedCholera ToxinDisease Models, AnimalDrug SynergismGanglia, SpinalGAP-43 ProteinInterleukin-6MaleMiceMice, KnockoutNerve Growth FactorsNerve RegenerationNeuronsRatsRats, WistarSciatic NerveSciatic NeuropathySpinal CordSpinal Cord InjuriesConceptsDorsal root gangliaInterleukin-6Sensory neuronsConditioning injuryDorsal columnsIntact dorsal root gangliaSoluble IL-6 receptorHost CNS tissueAdult sensory neuronsIL-6 upregulationDorsal column axonsDorsal column afferentsExogenous IL-6Cytokine interleukin-6IL-6 receptorGrowth-associated protein GAP43Neurite extensionConditioning lesionChondroitin sulfate proteoglycanNT-3Myelin inhibitorsDRG cellsRoot gangliaSciatic nerveInjury site
2002
Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury
Gardiner NJ, Cafferty WB, Slack SE, Thompson SW. Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury. Journal Of Neurochemistry 2002, 83: 100-109. PMID: 12358733, DOI: 10.1046/j.1471-4159.2002.01101.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAxotomyBlotting, WesternCell CompartmentationCell MembraneCell NucleusCytokine Receptor gp130CytoplasmDisease Models, AnimalGanglia, SpinalLeukemia Inhibitory Factor Receptor alpha SubunitMaleMembrane GlycoproteinsNeurons, AfferentPhenotypeProtein SubunitsRatsRats, WistarReceptors, CytokineReceptors, OSM-LIFSciatic NerveSciatic NeuropathyConceptsLeukemia inhibitory factor receptorDorsal root gangliaSensory neuronesNerve injuryAdult rat sensory neuronesSmall diameter sensory neuronesReceptor subunitsSensory neuropeptide CGRPSciatic nerve axotomyMale adult ratsIL-6 cytokinesExpression of gp130Rat sensory neuronesAdult nervous systemInhibitory factor receptorNeuropeptide CGRPIL-6 familyNerve axotomySignal-transducing receptor subunitInterleukin-6 familyRoot gangliaAdult sensory neuronesLevel of gp130Isolectin B4Adult rats
2001
Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons
Cafferty W, Gardiner N, Gavazzi I, Powell J, McMahon S, Heath J, Munson J, Cohen J, Thompson S. Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons. Journal Of Neuroscience 2001, 21: 7161-7170. PMID: 11549727, PMCID: PMC6762988, DOI: 10.1523/jneurosci.21-18-07161.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxotomyCalcitonin Gene-Related PeptideCell DivisionCell SurvivalCells, CulturedCytoprotectionFemaleGanglia, SpinalGrowth InhibitorsInjections, SpinalInterleukin-6Leukemia Inhibitory FactorLymphokinesMaleMiceMice, KnockoutNerve FibersNerve RegenerationNeuritesNeurons, AfferentPhenotypeRatsRats, WistarSciatic NerveTibial NerveConceptsLeukemia inhibitory factorLIF-/- miceAdult sensory neuronsSensory neuronsConditioning injuryInhibitory factorPeptidergic sensory neuronsMammalian sensory neuronsIntrinsic growth capacityExogenous leukemia inhibitory factorNerve damageReceptor antagonistNeuronsConditioning responseNeurite outgrowthInjuryGrowth statusVivoNormal regenerationStatusAntagonistGrowth capacityMice