2009
Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord
Duffy P, Schmandke A, Schmandke A, Sigworth J, Narumiya S, Cafferty WB, Strittmatter SM. Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord. Journal Of Neuroscience 2009, 29: 15266-15276. PMID: 19955379, PMCID: PMC2855556, DOI: 10.1523/jneurosci.4650-09.2009.Peer-Reviewed Original ResearchMeSH KeywordsAmidesAnalysis of VarianceAnimalsAxonsBehavior, AnimalBrain InjuriesCA1 Region, HippocampalCells, CulturedCholera ToxinEnzyme InhibitorsGanglia, SpinalGene Expression RegulationMedian NeuropathyMiceMice, Inbred C57BLMice, KnockoutMyelin ProteinsNerve RegenerationNeuronsNogo ProteinsPyridinesReceptors, Calcitonin Gene-Related PeptideRhizotomyRho-Associated KinasesSpinal Cord InjuriesTime FactorsVersicansConceptsSpinal cordCNS traumaFunctional recoveryBasso Mouse Scale scoresSpinal Cord Injury StudyAxonal growthDorsal root entry zoneDorsal root ganglion neuronsAdult mouse spinal cordAxonal growth inhibitorsSpinal cord hemisectionRoot entry zoneSpinal cord injuryCaudal spinal cordMouse spinal cordDorsal hemisectionRaphespinal axonsDorsal rhizotomyCrush injuryCord hemisectionCorticospinal axonsChondroitin sulfate proteoglycanCord injuryGanglion neuronsInjury paradigms
2005
Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation
Qiu J, Cafferty WB, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation. Journal Of Neuroscience 2005, 25: 1645-1653. PMID: 15716400, PMCID: PMC6725934, DOI: 10.1523/jneurosci.3269-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAxonsAxotomyCells, CulturedCholera ToxinCytokine Receptor gp130DNA-Binding ProteinsGanglia, SpinalGAP-43 ProteinInfusion Pumps, ImplantableJanus Kinase 2MaleMembrane GlycoproteinsNerve CrushNerve RegenerationNeuritesPhosphorylationProtein Processing, Post-TranslationalProtein-Tyrosine KinasesProto-Oncogene ProteinsRatsRats, WistarSciatic NerveSignal TransductionSpinal Cord InjuriesSTAT3 Transcription FactorTrans-ActivatorsTyrphostinsConceptsSciatic nerve transectionAdult spinal cordSpinal cordSignal transducerConditioning injuryNerve transectionDorsal columnsPerineural infusionAxonal regenerationTranscription 3 (STAT3) activationDorsal root ganglion neuronsTime-dependent phosphorylationProximal nerve stumpSpinal axon regenerationTranscription factorsTranscription 3Peripheral injurySTAT3 activationDRG neuronsNerve stumpInhibitor AG490Ganglion neuronsSciatic nerveGlial scarSTAT3 phosphorylation
2004
Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice
Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice. Journal Of Neuroscience 2004, 24: 4432-4443. PMID: 15128857, PMCID: PMC6729445, DOI: 10.1523/jneurosci.2245-02.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCell DifferentiationCells, CulturedCholera ToxinDisease Models, AnimalDrug SynergismGanglia, SpinalGAP-43 ProteinInterleukin-6MaleMiceMice, KnockoutNerve Growth FactorsNerve RegenerationNeuronsRatsRats, WistarSciatic NerveSciatic NeuropathySpinal CordSpinal Cord InjuriesConceptsDorsal root gangliaInterleukin-6Sensory neuronsConditioning injuryDorsal columnsIntact dorsal root gangliaSoluble IL-6 receptorHost CNS tissueAdult sensory neuronsIL-6 upregulationDorsal column axonsDorsal column afferentsExogenous IL-6Cytokine interleukin-6IL-6 receptorGrowth-associated protein GAP43Neurite extensionConditioning lesionChondroitin sulfate proteoglycanNT-3Myelin inhibitorsDRG cellsRoot gangliaSciatic nerveInjury site