Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation
Qiu J, Cafferty WB, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation. Journal Of Neuroscience 2005, 25: 1645-1653. PMID: 15716400, PMCID: PMC6725934, DOI: 10.1523/jneurosci.3269-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAxonsAxotomyCells, CulturedCholera ToxinCytokine Receptor gp130DNA-Binding ProteinsGanglia, SpinalGAP-43 ProteinInfusion Pumps, ImplantableJanus Kinase 2MaleMembrane GlycoproteinsNerve CrushNerve RegenerationNeuritesPhosphorylationProtein Processing, Post-TranslationalProtein-Tyrosine KinasesProto-Oncogene ProteinsRatsRats, WistarSciatic NerveSignal TransductionSpinal Cord InjuriesSTAT3 Transcription FactorTrans-ActivatorsTyrphostinsConceptsSciatic nerve transectionAdult spinal cordSpinal cordSignal transducerConditioning injuryNerve transectionDorsal columnsPerineural infusionAxonal regenerationTranscription 3 (STAT3) activationDorsal root ganglion neuronsTime-dependent phosphorylationProximal nerve stumpSpinal axon regenerationTranscription factorsTranscription 3Peripheral injurySTAT3 activationDRG neuronsNerve stumpInhibitor AG490Ganglion neuronsSciatic nerveGlial scarSTAT3 phosphorylation