2008
Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function
Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB. Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function. Journal Of Neuroscience 2008, 28: 11998-12009. PMID: 19005065, PMCID: PMC3844838, DOI: 10.1523/jneurosci.3877-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAfferent PathwaysAnimalsChondroitin ABC LyaseChondroitin Sulfate ProteoglycansDisease Models, AnimalMaleNerve RegenerationNeural ConductionNeuronal PlasticityRatsRats, WistarRecovery of FunctionRhizotomySensation DisordersSensory Receptor CellsSpinal CordSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeConceptsSpinal cord injuryFunctional restorationSensory functionSpinal sensory functionsPrimary afferent terminalsVivo electrophysiological recordingsIntact spinal circuitsEnzyme chondroitinase ABCIntrinsic growth potentialAfferent terminalsBehavioral recoveryIntraspinal injectionCord injurySensory deficitsSpinal cordSpinal circuitsAdult ratsMature CNSTherapeutic interventionsExperimental therapeuticsElectrophysiological recordingsAxon growthInjuryIntact pathwaysEnhance function
2005
Regulation of neuropilin 1 by spinal cord injury in adult rats
Agudo M, Robinson M, Cafferty W, Bradbury EJ, Kilkenny C, Hunt SP, McMahon SB. Regulation of neuropilin 1 by spinal cord injury in adult rats. Molecular And Cellular Neuroscience 2005, 28: 475-484. PMID: 15737738, DOI: 10.1016/j.mcn.2004.10.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal hornCord injurySpinal cordAdult ratsAdjacent dorsal root gangliaNeuropilin-1Dorsal root rhizotomyDorsal root gangliaUnilateral rhizotomyMicroglial cellsRoot gangliaSensory projectionsControl animalsRhizotomyWestern blottingBlood vesselsInjuryRT-PCRSuperficial layersCordLesionsRatsSitu hybridizationHorn
2002
Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury
Gardiner NJ, Cafferty WB, Slack SE, Thompson SW. Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury. Journal Of Neurochemistry 2002, 83: 100-109. PMID: 12358733, DOI: 10.1046/j.1471-4159.2002.01101.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAxotomyBlotting, WesternCell CompartmentationCell MembraneCell NucleusCytokine Receptor gp130CytoplasmDisease Models, AnimalGanglia, SpinalLeukemia Inhibitory Factor Receptor alpha SubunitMaleMembrane GlycoproteinsNeurons, AfferentPhenotypeProtein SubunitsRatsRats, WistarReceptors, CytokineReceptors, OSM-LIFSciatic NerveSciatic NeuropathyConceptsLeukemia inhibitory factor receptorDorsal root gangliaSensory neuronesNerve injuryAdult rat sensory neuronesSmall diameter sensory neuronesReceptor subunitsSensory neuropeptide CGRPSciatic nerve axotomyMale adult ratsIL-6 cytokinesExpression of gp130Rat sensory neuronesAdult nervous systemInhibitory factor receptorNeuropeptide CGRPIL-6 familyNerve axotomySignal-transducing receptor subunitInterleukin-6 familyRoot gangliaAdult sensory neuronesLevel of gp130Isolectin B4Adult rats
2000
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
Kerr B, Cafferty W, Gupta Y, Bacon A, Wynick D, McMahon S, Thompson S. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. European Journal Of Neuroscience 2000, 12: 793-802. PMID: 10762308, DOI: 10.1046/j.1460-9568.2000.00967.x.Peer-Reviewed Original ResearchConceptsPeripheral nerve injuryNerve injuryBehavioral hypersensitivityExogenous galaninNociceptive processingAdult ratsNervous systemSpinal cord dorsal hornMutant miceNociceptive sensory inputsPersistent behavioral hypersensitivityNeuropathic pain behaviorsNeurotransmitter/neuromodulatorGalanin knockout miceCentral nervous systemC-fos expressionEndogenous galaninGalanin levelsNociceptive deficitsWild-type controlsDorsal hornChronic administrationGalanin expressionExcitatory effectsIntrathecal delivery