2004
A role for talin in presynaptic function
Morgan JR, Di Paolo G, Werner H, Shchedrina VA, Pypaert M, Pieribone VA, De Camilli P. A role for talin in presynaptic function. Journal Of Cell Biology 2004, 167: 43-50. PMID: 15479735, PMCID: PMC2172527, DOI: 10.1083/jcb.200406020.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBlotting, WesternCell AdhesionClathrinEndocytosisGlutathione TransferaseHumansLampreysLipid MetabolismMicroscopy, ConfocalMicroscopy, Electron, TransmissionPeptidesPhosphotransferases (Alcohol Group Acceptor)Protein BindingProtein Structure, TertiaryRatsSynapsesTalinTime FactorsConceptsSynaptic vesicle endocytosisClathrin-mediated synaptic vesicle endocytosisClathrin-coated pitsEndocytic defectsMajor phosphatidylinositolActin cytoskeletonVesicle endocytosisActin dynamicsKinase interactionTalinPIP kinasePresynaptic compartmentFunctional linkCell adhesionNeuronal synapsesEndocytosisSynaptic rolePresynaptic functionSynaptic actinActinPhosphatidylinositolSynaptic structureIgammaClathrinCytoskeleton
2002
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton
Shupliakov O, Bloom O, Gustafsson JS, Kjaerulff O, Löw P, Tomilin N, Pieribone VA, Greengard P, Brodin L. Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 14476-14481. PMID: 12381791, PMCID: PMC137908, DOI: 10.1073/pnas.212381799.Peer-Reviewed Original ResearchConceptsSynaptic vesicle clustersVesicle clustersSynaptic vesiclesEndocytic zonesC2 toxinClostridium botulinum C2 toxinClathrin-coated pitsSynaptic vesicle cycleSynaptic vesicle recyclingAccumulation of aggregatesRole of actinLamprey reticulospinal synapseBotulinum C2 toxinActin functionVesicle transportActin cytoskeletonCatalytic subunitVesicle cycleVesicle recyclingPlasma membraneActin filamentsImpaired recyclingReversible anchoringRecycled vesiclesS1 fragment