2018
Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins
Cijsouw T, Ramsey AM, Lam TT, Carbone BE, Blanpied TA, Biederer T. Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins. Proteomes 2018, 6: 48. PMID: 30487426, PMCID: PMC6313906, DOI: 10.3390/proteomes6040048.Peer-Reviewed Original ResearchProximity labelingLabel-free quantitation mass spectrometryReceptor-type tyrosine-protein phosphatase zetaProximity labeling approachCell-cell contactSynaptic cleftPost-synaptic specializationsProteomic contentSynapse heterogeneitySynCAM 1Confocal microcopySurface proteinsCell surfaceProteomeSuper-resolution imagingCultured cortical neuronsMammalian brainLabeling approachMolecular compositionReporterProteinCortical neuronsFunctional organizationExcitatory synapsesDiverse set
2001
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins*
Biederer T, Südhof T. CASK and Protein 4.1 Support F-actin Nucleation on Neurexins*. Journal Of Biological Chemistry 2001, 276: 47869-47876. PMID: 11604393, DOI: 10.1074/jbc.m105287200.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid SequenceAnimalsBinding SitesCalcium-Calmodulin-Dependent Protein KinasesCytoplasmCytoskeletal ProteinsGlycophorinsGuanylate KinasesMembrane ProteinsMolecular Sequence DataNerve Tissue ProteinsNeuropeptidesNucleoside-Phosphate KinaseProtein BindingRatsSequence Homology, Amino AcidSpectrinConceptsProtein 4.1Actin cytoskeletonActin filamentsBrain-enriched isoformF-actin nucleationCytosolic C-terminusClass of proteinsCell surface proteinsCytosolic tailPDZ domainAdaptor proteinCellular processesMembrane organizationC-terminusNeurexinsProtein p55Glycophorin CCell surfaceRat brain extractsIntercellular junctionsSpectrin filamentsErythrocyte isoformsCytoskeletonProteinLocomotion of cells