Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response
Feinerman O, Jentsch G, Tkach KE, Coward JW, Hathorn MM, Sneddon MW, Emonet T, Smith KA, Altan-Bonnet G. Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response. Molecular Systems Biology 2010, 6: msb201090. PMID: 21119631, PMCID: PMC3010113, DOI: 10.1038/msb.2010.90.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCoculture TechniquesEnzyme-Linked Immunosorbent AssayImmunity, CellularInterleukin-2Interleukin-2 Receptor alpha SubunitMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalSingle-Cell AnalysisStaining and LabelingT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryConceptsInterleukin-2T cellsImmune responseSingle-cell quantificationSingle-cell measurementsEffector T cellsRegulatory T cellsIL-2 responseSurvival signalsReceptor expression levelsIndividual cellsSuppressive capacityCytokine regulationExpression levelsImmune systemHeterogeneous cellsSpecific suppressionSilico modelingPopulation levelCellsEffectorsResponseCritical plasticityPopulationSuppression