2020
Nesfatin-1 decreases the motivational and rewarding value of food
Dore R, Krotenko R, Reising JP, Murru L, Sundaram SM, Di Spiezio A, Müller-Fielitz H, Schwaninger M, Jöhren O, Mittag J, Passafaro M, Shanabrough M, Horvath TL, Schulz C, Lehnert H. Nesfatin-1 decreases the motivational and rewarding value of food. Neuropsychopharmacology 2020, 45: 1645-1655. PMID: 32353862, PMCID: PMC7419560, DOI: 10.1038/s41386-020-0682-3.Peer-Reviewed Original ResearchMeSH KeywordsCalcium-Binding ProteinsDNA-Binding ProteinsMotivationNerve Tissue ProteinsNucleobindinsRewardConceptsNUCB2/nesfatinNesfatin-1Nucleobindin-2Food intakeNesfatin-1 actionDopaminergic neuron activityFasting-induced increaseReward-related brain areasOutward potassium currentHedonic pathwaysHedonic feedingGABA neuronsLeptin resistanceBrain areasPotassium currentNeuron activityFood rewardEnergy intakeReward circuitryElectrophysiological recordingsNesfatinCentral administrationEnhanced sensitizationIntakeHomeostatic mechanisms
2014
Function and Dysfunction of Hypocretin/Orexin: An Energetics Point of View
Gao XB, Horvath T. Function and Dysfunction of Hypocretin/Orexin: An Energetics Point of View. Annual Review Of Neuroscience 2014, 37: 101-116. PMID: 24821311, DOI: 10.1146/annurev-neuro-071013-013855.Peer-Reviewed Original Research
2007
Neurobiology of Feeding and Energy Expenditure
Gao Q, Horvath TL. Neurobiology of Feeding and Energy Expenditure. Annual Review Of Neuroscience 2007, 30: 367-398. PMID: 17506645, DOI: 10.1146/annurev.neuro.30.051606.094324.Peer-Reviewed Original ResearchConceptsEnergy expenditureNeurobiology of feedingPeripheral metabolic signalsBrain homeostatic systemsMechanism of actionBrain involvementChronic regulationPharmacological techniquesNeuronal controlNeuronal mechanismsEnergy homeostasisComplex feeding behaviorHomeostatic systemMetabolic signalsFeeding behaviorInvolvementCurrent understandingBrain