2014
Hypothalamic Sidedness in Mitochondrial Metabolism
Toth I, Kiss DS, Goszleth G, Bartha T, Frenyo LV, Naftolin F, Horvath TL, Zsarnovszky A. Hypothalamic Sidedness in Mitochondrial Metabolism. Reproductive Sciences 2014, 21: 1492-1498. PMID: 24740989, DOI: 10.1177/1933719114530188.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCell RespirationEnergy MetabolismEstrusFemaleHomeostasisHypothalamusMaleMitochondriaNeuronsOxygen ConsumptionRats, WistarSex FactorsConceptsMitochondrial metabolism
2013
Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning
Ozcan C, Palmeri M, Horvath TL, Russell KS, Russell RR. Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning. AJP Heart And Circulatory Physiology 2013, 304: h1192-h1200. PMID: 23457013, PMCID: PMC3652089, DOI: 10.1152/ajpheart.00592.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsArrhythmias, CardiacCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCoronary OcclusionIn Vitro TechniquesIon ChannelsIschemic Preconditioning, MyocardialMaleMiceMice, Inbred C57BLMitochondrial ProteinsMyocardial InfarctionMyocardial Reperfusion InjuryMyocytes, CardiacReactive Oxygen SpeciesUncoupling Protein 2Uncoupling Protein 3Ventricular DysfunctionConceptsIschemia-reperfusion injuryR injuryIschemic preconditioningWT heartsMyocardial energeticsMouse heartsReactive oxygen speciesLeft coronary arteryLeft ventricular functionPostischemic functional recoveryWild-type mouse heartsUncoupling proteinDecreased ATP contentR arrhythmiasLarge infarctsVentricular functionFunctional recoveryWT miceCoronary arteryProtective efficacyCardioprotective efficacyMyocardial vulnerabilityVivo modelInjuryRole of UCPs
2009
The role of mitochondrial uncoupling proteins in lifespan
Dietrich MO, Horvath TL. The role of mitochondrial uncoupling proteins in lifespan. Pflügers Archiv - European Journal Of Physiology 2009, 459: 269-275. PMID: 19760284, PMCID: PMC2809791, DOI: 10.1007/s00424-009-0729-0.Peer-Reviewed Original ResearchConceptsMitochondrial inner membraneCellular biochemical reactionsMitochondrial uncoupling proteinProduction of ATPCellular functionsInner membraneSpecialized proteinsBreakdown of lipidsMain organellesExcess of ROSPhysiological uncouplingOxidative phosphorylationUncoupling proteinAdenosine triphosphateOxygen reactive speciesROS productionProteinEnergetic substratesBiochemical reactionsCellular damageMitochondriaROSIntermediate substrateUCPShed light
2003
Uncoupling Protein 2 Prevents Neuronal Death Including that Occurring during Seizures: A Mechanism for Preconditioning
Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL. Uncoupling Protein 2 Prevents Neuronal Death Including that Occurring during Seizures: A Mechanism for Preconditioning. Endocrinology 2003, 144: 5014-5021. PMID: 12960023, DOI: 10.1210/en.2003-0667.Peer-Reviewed Original ResearchConceptsFree radical-induced cell deathFree radical-induced damageCell deathSeizure inductionSeizure activityNeuronal deathRadical-induced damageTransgenic miceNeurodegenerative disordersCellular stressRobust reductionUCP2 levelsParallel decreaseDeathATP levelsPC12 cellsProtein 2Mitochondrial uncoupling proteinUCP2Mitochondrial numberCellular energy productionFree radicalsHarmful effectsUncoupling proteinEpilepsy