2020
Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States
Kiss DS, Toth I, Jocsak G, Bartha T, Frenyo LV, Barany Z, Horvath TL, Zsarnovszky A. Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States. Reproductive Sciences 2020, 27: 1197-1205. PMID: 32046448, PMCID: PMC7181557, DOI: 10.1007/s43032-019-00131-3.Peer-Reviewed Original ResearchConceptsSatiety stateMale ratsFood intakeImpact of gonadectomyRight hemisphereSleep-wake behaviorHypothalamic functionMale rodentsMetabolic asymmetryScheduled feedingFunctional lateralizationHypothalamusEx vivoRegulatory centersRatsMetabolic differencesHomeostatic processesFunctional asymmetryIntakeLateralizationRecent findingsPresent studyReproductive controlGonadectomySatiety
2015
Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats
Toth I, Kiss DS, Jocsak G, Somogyi V, Toronyi E, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats. PLOS ONE 2015, 10: e0137462. PMID: 26339901, PMCID: PMC4560379, DOI: 10.1371/journal.pone.0137462.Peer-Reviewed Original ResearchConceptsAd libitum fed animalsFemale ratsRight-sided dominanceSatiety stateFed animalsOvariectomized female ratsContribution of estrogenMetabolic differencesHours of fastingIntensity of cellsState 3 mitochondrial respirationHypothalamic functionMetabolic asymmetryTissue metabolismHypothalamusEstrogenProportion of animalsHypothalamic asymmetryRatsAd libitumLateralizationHigher centersMitochondrial respiration rateEnergy metabolism
2014
Hypothalamic Sidedness in Mitochondrial Metabolism
Toth I, Kiss DS, Goszleth G, Bartha T, Frenyo LV, Naftolin F, Horvath TL, Zsarnovszky A. Hypothalamic Sidedness in Mitochondrial Metabolism. Reproductive Sciences 2014, 21: 1492-1498. PMID: 24740989, DOI: 10.1177/1933719114530188.Peer-Reviewed Original Research
2012
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. Journal Of Clinical Investigation 2012, 122: 3900-3913. PMID: 23064363, PMCID: PMC3484452, DOI: 10.1172/jci64102.Peer-Reviewed Original ResearchConceptsGlial structural proteinsPathology of obesityHypothalamic proopiomelanocortin (POMC) neuronsGlial cell activityOffspring of mothersHigh-fat dietActivity of neuronsExpression of glucoseProopiomelanocortin neuronsHypothalamic astrocytesGlial cellsBody weightSynaptic efficacyGlutamate transportersNeuronal functionCell activityLeptinGlucose uptakeMetabolic statusElectrical activityMetabolic signalsNeuronsAppetiteGlucose transporterKey regulator
2011
Ghrelin-induced hypothermia: A physiological basis but no clinical risk
Wiedmer P, Strasser F, Horvath TL, Blum D, DiMarchi R, Lutz T, Schürmann A, Joost HG, Tschöp MH, Tong J. Ghrelin-induced hypothermia: A physiological basis but no clinical risk. Physiology & Behavior 2011, 105: 43-51. PMID: 21513721, PMCID: PMC3146973, DOI: 10.1016/j.physbeh.2011.03.027.Peer-Reviewed Original ResearchConceptsGhrelin treatmentBody temperatureApplication of ghrelinMedial preoptic areaPotential anatomical basisCold-sensitive neuronsGhrelin infusionBody core temperatureChronic i.Positive energy balanceGhrelin receptorPreoptic areaAxon terminalsClinical riskFood intakeGhrelinHealthy humansSerious hypothermiaMale subjectsPhysiologic circumstancesAnatomical basisHypothermiaCold exposureRelevant decreaseEnergy expenditureDifferential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels
García-Cáceres C, Fuente-Martín E, Burgos-Ramos E, Granado M, Frago LM, Barrios V, Horvath T, Argente J, Chowen JA. Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels. Endocrinology 2011, 152: 1809-1818. PMID: 21343257, PMCID: PMC3860256, DOI: 10.1210/en.2010-1252.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinChronic leptin exposureSynaptic inputsAstrocyte morphologyLeptin exposureGFAP levelsGlial structural proteinsSynaptic protein densityChronic leptin administrationAcute leptin treatmentSynaptic protein levelsAdult male ratsCentral leptin resistanceFibrillary acidic proteinLevels 1 hPossible direct effectGlial ensheathingNeonatal overnutritionGlial activationLeptin levelsLeptin administrationHypothalamic neuronsLeptin resistanceLeptin treatmentMale rats
2002
Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury
Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, Horvath TL. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochemical Pharmacology 2002, 64: 363-367. PMID: 12147286, DOI: 10.1016/s0006-2952(02)01166-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBrain InjuriesDisease Models, AnimalEntorhinal CortexGene Transfer TechniquesImmunohistochemistryIon ChannelsLearningMaleMembrane Transport ProteinsMemoryMiceMice, Inbred C57BLMitochondriaMitochondrial ProteinsNerve DegenerationNeuronsProtective AgentsProteinsRatsRats, WistarSignal TransductionStress, PhysiologicalUncoupling Protein 2Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe
Fernández‐Galaz M, Diano S, Horvath TL, Garcia‐Segura L. Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe. Journal Of Neuroendocrinology 2002, 14: 429-434. PMID: 12047717, DOI: 10.1046/j.1365-2826.2002.00783.x.Peer-Reviewed Original ResearchConceptsEffects of leptinRaphe nucleusDorsal rapheFemale ratsMidbrain serotonergic systemsSerotonergic systemSerotonergic neuronesRaphe neuronesDistribution of neuronesMouse recombinant leptinIntracerebroventricular administrationLeptin administrationLeptin uptakeLeptin treatmentPeriventricular grayMale ratsFood intakeRecombinant leptinLeptinSleep patternsGender differencesBrain functionImportant mediatorLeptin accumulationNeurones
2001
Turnover of Rat Brain Perivascular Cells
Bechmann I, Kwidzinski E, Kovac A, Simbürger E, Horvath T, Gimsa U, Dirnagl U, Priller J, Nitsch R. Turnover of Rat Brain Perivascular Cells. Experimental Neurology 2001, 168: 242-249. PMID: 11259112, DOI: 10.1006/exnr.2000.7618.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasement MembraneBrainCell MovementFluorescent DyesMacrophagesOligodendrogliaRatsRats, WistarConceptsBrain perivascular spacesBone marrow transplantationPerivascular spacesPerivascular cellsMarrow transplantationAdult ratsBlood borne macrophagesBrain perivascular cellsHealthy adult ratsEx vivo isolationMonocyte/macrophage lineageHigh phagocytic capacityNormal adult ratsMHC mismatchIntraventricular injectionBrain parenchymaIntracerebral injectionAntigen presentationImmune surveillanceDonor macrophagesPhagocytic capacityMacrophage lineageMacrophagesVivo isolationSame animals
1998
Tracing of the entorhinal‐hippocampal pathway in vitro
Kluge A, Hailer N, Horvath T, Bechmann I, Nitsch R. Tracing of the entorhinal‐hippocampal pathway in vitro. Hippocampus 1998, 8: 57-68. PMID: 9519887, DOI: 10.1002/(sici)1098-1063(1998)8:1<57::aid-hipo6>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsOuter molecular layerPerforant pathDentate gyrusEntorhinal cortexEntorhinal-hippocampal interactionPerforant path axonsOrganotypic slice culturesMini-RubyPerforant fibersVitro tracingAnterograde degenerationDendritic shaftsLesion paradigmMicroglial cellsNeuronal degenerationEntorhinal neuronsNeurotoxin treatmentMolecular layerSlice culturesAxonal materialGrowth factorSubsequent phagocytosisGyrusEntorhinal-hippocampal regionFurther studies
1997
Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus
Horvath T, Garcia-Segura L, Naftolin F. Lack of Gonadotropin-Positive Feedback in the Male Rat Is Associated with Lack of Estrogen-Induced Synaptic Plasticity in the Arcuate Nucleus. Neuroendocrinology 1997, 65: 136-140. PMID: 9067991, DOI: 10.1159/000127173.Peer-Reviewed Original ResearchConceptsArcuate nucleusFemale ratsSynaptic plasticitySynaptic retractionMale ratsSynapse countsEstrogen-induced synaptic plasticityFemale arcuate nucleusVehicle-injected groupHypothalamic arcuate nucleusAdministration of estrogenAfternoon of proestrusQuantitative electron microscopic analysisOil-injected controlsGonadotropin secretionSynaptic reorganizationSynaptic countsConstant estrusEndogenous estrogensSynaptic remodelingSingle injectionTreatment groupsHormone injectionEstrogenOvarian cycle
1996
Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge.
Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-80. PMID: 8940386, DOI: 10.1210/endo.137.12.8940386.Peer-Reviewed Original ResearchConceptsSynaptic retractionArcuate nucleusAxosomatic synapsesPreovulatory gonadotropinEstrous cycleMorning of metestrusPhysiological synaptic plasticitySurge of gonadotropinsMorning of estrusPreovulatory LH surgePreovulatory estradiolPreovulatory levelsLH surgeGonadotropin surgeHypothalamic mechanismsSynaptic remodelingEstrogen diethylstilbestrolSynaptic plasticityGonadotropinOvarian cycleControl femalesSynapsesPositive controlEstradiolEstrogen