2015
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.Peer-Reviewed Original ResearchConceptsPOMC neuronsΒ-endorphinHypothalamic pro-opiomelanocortin (POMC) neuronsOpioid peptide β-endorphinHypothalamic POMC neuronsPromotion of feedingPro-opiomelanocortin (POMC) neuronsCannabinoid receptor 1CB1R activityPOMC activitySated miceHormone releaseHypothalamic administrationFood intakeCentral regulationNeuronal activityParadoxical increaseCB1RReceptor 1POMC cellsNeuronsMitochondrial adaptationsDecreased activityPOMC geneUnsuspected role
1997
Evidence Showing That β-Endorphin Regulates Cyclic Guanosine 3′,5′-Monophosphate (cGMP) Efflux: Anatomical and Functional Support for an Interaction between Opiates and Nitric Oxide
Pu S, Horvath TL, Diano S, Naftolin F, Kalra PS, Kalra SP. Evidence Showing That β-Endorphin Regulates Cyclic Guanosine 3′,5′-Monophosphate (cGMP) Efflux: Anatomical and Functional Support for an Interaction between Opiates and Nitric Oxide. Endocrinology 1997, 138: 1537-1543. PMID: 9075713, DOI: 10.1210/endo.138.4.5086.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-EndorphinCyclic GMPMicroscopy, ElectronMorphineNaloxoneNitric OxideNitric Oxide SynthasePreoptic AreaRatsConceptsExcitatory amino acidsMedial preoptic areaCGMP/Opioid influenceGnRH secretionNitric oxidePreoptic areaN-methyl-D-aspartate receptorsMu-opiate receptor agonistNOS-immunopositive cellsNOS-immunoreactive neuronsPituitary LH secretionOpiate receptor agonistsOpiate receptor antagonistRelease of GnRHCentral nervous systemDirect inhibitory controlExcitatory NMDATonic restraintLH secretionEndogenous opioidsNOS pathwayReceptor antagonistBeta-endorphinGonadal steroids
1993
Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement
Xu B, Sahu A, Crowley WR, Leranth C, Horvath T, Kalra SP. Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement. Endocrinology 1993, 133: 747-754. PMID: 8344213, DOI: 10.1210/endo.133.2.8344213.Peer-Reviewed Original ResearchConceptsEpisodic LH secretionPlasma LH levelsLH releaseLH secretionLH pulsesExcitatory componentLH levelsOVX ratsOvariectomized ratsMean plasma LH levelsAlpha-helical CRHBeta-endorphin neuronsInhibitory LH responseSuppression of LHLH pulse frequencyInfusion of naloxoneContinuous intraventricular infusionFrequency of LHRole of neuropeptidesNormal rabbit serumExogenous NPYNPY injectionLH responseIntracerebroventricular administrationIntraventricular administration
1992
GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area
Horvath TL, Naftolin F, Leranth C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area. Neuroscience 1992, 51: 391-399. PMID: 1281529, DOI: 10.1016/0306-4522(92)90323-t.Peer-Reviewed Original ResearchConceptsMedial preoptic areaPreoptic areaHormone-producing cellsArcuate nucleusHypothalamic beta-endorphin neuronsHormone-releasing hormone (LHRH) neuronsBeta-endorphin neuronsDirect estrogen actionHormone-containing neuronsVentromedial arcuate nucleusRetrograde tracer horseradish peroxidasePro-opiomelanocortin (POMC) neuronsCellular estrogen receptorsPro-opiomelanocortin cellsTracer horseradish peroxidaseΒ-endorphin cellsHormone neuronsImmunoreactive neuronsCatecholaminergic innervationCatecholaminergic neuronsRetrograde tracingSynaptic contactsEstrogen actionCatecholamine fibersAxon terminalsNeuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis
Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 1992, 131: 2461-2467. PMID: 1425443, DOI: 10.1210/endo.131.5.1425443.Peer-Reviewed Original ResearchConceptsPituitary LH releaseLH releaseOvariectomized ratsMediobasal hypothalamusSynaptic connectionsNPY-immunoreactive axonsBeta-endorphin systemSynaptic membrane specializationsRat mediobasal hypothalamusDirect synaptic connectionsDiaminobenzidine reactionLHRH neuronsNPY neuronsDual effectHypothalamic NPYLH secretionMedial basalLHRH secretionOvarian steroidsPrecise neural mechanismsFemale ratsAxon terminalsElectron microscopic examinationPeptidergic systemsNeuroendocrine regulationBeta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study
Horvath TL, Naftolin F, Leranth C. Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology 1992, 131: 1547-1555. PMID: 1354605, DOI: 10.1210/endo.131.3.1354605.Peer-Reviewed Original ResearchConceptsDopamine neuronsZona incertaDopamine cellsSynaptic connectionsCell bodiesDouble immunostaining experimentsHypophyseal hormone secretionHypothalamic dopaminergic systemFemale rat brainHypothalamic dopaminergic neuronsDorsomedial hypothalamic nucleusDopamine cell bodiesReceptor-containing cellsDouble immunostaining studiesLight microscopic examinationPutative synaptic connectionsLH releaseDopamine innervationImmunoreactive boutonsPeriventricular areaDopaminergic neuronsPRL secretionSynaptic contactsArcuate nucleusHormone secretion