2015
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2015, 160: 1222-1232. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.Peer-Reviewed Original ResearchConceptsHypothalamic AgRP neuronsAgRP neuronsNeuropeptidergic signalingReceptor signalingFunctional rolePotential therapeutic avenuesAgRP neuron activationStereotypic behaviorFeeding behaviorRepetitive behaviorsSignalingTherapeutic avenuesFood triggersAdult miceNervous systemDecreased anxietyNeuronsMinor effectActivationFood consumptionNeuron activationGoal-directed behaviorSensory informationFlexible goal-directed behaviorDisease
2004
The floating blueprint of hypothalamic feeding circuits
Horvath TL, Diano S. The floating blueprint of hypothalamic feeding circuits. Nature Reviews Neuroscience 2004, 5: 662-667. PMID: 15263896, DOI: 10.1038/nrn1479.Peer-Reviewed Original ResearchConceptsHypothalamic feeding circuitsNew therapeutic avenuesMetabolic parametersFood intakeMetabolic disordersSynaptic plasticityTherapeutic avenuesLesion studiesGenetic findingsEnergy expenditureEarlier lesion studiesCircuit changesHypothalamusImportant regulatorUnexpected findingMetabolism regulationFeeding circuitFindingsIntakeAppetite