2022
A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
Korchynska S, Rebernik P, Pende M, Boi L, Alpár A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath TL, Fisone G, Dodt HU, Hökfelt T, Harkany T, Romanov RA. A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice. Nature Communications 2022, 13: 5944. PMID: 36209152, PMCID: PMC9547883, DOI: 10.1038/s41467-022-33584-3.Peer-Reviewed Original ResearchConceptsLateral septumDopamine neuronsSuprachiasmatic nucleusSomatostatin-containing neuronsStimulation ex vivoAmphetamine-induced hyperlocomotionRegulation of locomotionDopamine outputChemogenetic inhibitionNeuropeptidergic innervationPeriventricular nucleusChemogenetic manipulationHypothalamic lociSynaptic targetsAnterior subdivisionEx vivoBrain clockNeuronsSedentary periodL activityHyperlocomotionCellular targetsMicePeVNInnervation
2012
Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center
Horvath TL, Abizaid A, Dietrich MO, Li Y, Takahashi JS, Bass J. Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center. Molecular Metabolism 2012, 1: 79-85. PMID: 24024121, PMCID: PMC3757645, DOI: 10.1016/j.molmet.2012.08.003.Peer-Reviewed Original ResearchHypothalamic neuronsOrexin/hypocretin neuronsOrexin/hypocretin systemUnique anatomical distributionDirect synaptic inputGrowth hormone releaseLateral geniculate nucleusHypothalamic arousal systemsHypocretin neuronsHypothalamic slicesGeniculate nucleusHormone releaseHypocretin systemAnatomical distributionArousal centersSynaptic inputsVisual centersGhrelin mRNAGhrelinArousal systemNeuronsKey mediatorCircadian patternSuprachiasmatic nucleusElectrophysiological activity
2004
Direct visual and circadian pathways target neuroendocrine cells in primates
Abizaid A, Horvath B, Keefe DL, Leranth C, Horvath TL. Direct visual and circadian pathways target neuroendocrine cells in primates. European Journal Of Neuroscience 2004, 20: 2767-2776. PMID: 15548220, DOI: 10.1111/j.1460-9568.2004.03737.x.Peer-Reviewed Original ResearchConceptsSuprachiasmatic nucleusRetinal inputNeuroendocrine cellsDirect retinal inputHormone-releasing hormoneNon-human primatesHypothalamic suprachiasmatic nucleusSCN efferentsHypothalamic areaHypothalamic neuronsHypothalamic sitesMonosynaptic pathwayVisual afferentsHypothalamic regulatorGonadal axisHormone releaseNeuroendocrine functionPituitary gonadotropsPhotic modulationNeuronsCircadian pacemakerVervet monkeysPresent studyTracing techniquesCircadian clockSex differences in adult suprachiasmatic nucleus neurons emerging late prenatally in rats
Abizaid A, Mezei G, Sotonyi P, Horvath TL. Sex differences in adult suprachiasmatic nucleus neurons emerging late prenatally in rats. European Journal Of Neuroscience 2004, 19: 2488-2496. PMID: 15128402, DOI: 10.1111/j.0953-816x.2004.03359.x.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnalysis of VarianceAnimalsAnimals, NewbornArginine VasopressinBromodeoxyuridineCalbindin 1CalbindinsCell CountEmbryo, MammalianFemaleGeniculate BodiesGlial Fibrillary Acidic ProteinImmunohistochemistryMaleNeuronsNeuropeptide YPregnancyPrenatal Exposure Delayed EffectsRatsRats, Sprague-DawleyS100 Calcium Binding Protein GSex CharacteristicsSuprachiasmatic NucleusTestosterone PropionateConceptsSuprachiasmatic nucleusGonadal steroidsFemale ratsLate gestationSex differencesPregnant female ratsVasoactive intestinal peptideGestational day 18Postnatal day 60BrdU-labeled cellsCalbindin-D28KSuprachiasmatic nucleus neuronsCircadian rhythmIntestinal peptideNucleus neuronsDouble immunocytochemistryGonadal functionTestosterone propionateBrain sectionsRat fetusesDay 18Day 60Cell groupsRatsSCN cells
1998
An Alternate Pathway for Visual Signal Integration into the Hypothalamo-Pituitary Axis: Retinorecipient Intergeniculate Neurons Project to Various Regions of the Hypothalamus and Innervate Neuroendocrine Cells Including Those Producing Dopamine
Horvath TL. An Alternate Pathway for Visual Signal Integration into the Hypothalamo-Pituitary Axis: Retinorecipient Intergeniculate Neurons Project to Various Regions of the Hypothalamus and Innervate Neuroendocrine Cells Including Those Producing Dopamine. Journal Of Neuroscience 1998, 18: 1546-1558. PMID: 9454860, PMCID: PMC6792709, DOI: 10.1523/jneurosci.18-04-01546.1998.Peer-Reviewed Original ResearchConceptsHypothalamo-pituitary axisIntergeniculate leafletNeuroendocrine cellsSuprachiasmatic nucleusHypothalamic dopamine neuronsMedial preoptic areaFenestrated capillariesPopulations of neuronsNeurons projectBilateral enucleationHypothalamic projectionsDistal dendritesRetrograde tracerVentromedial nucleusDopamine neuronsIntraperitoneal injectionProjection sitesPeriventricular nucleusPreoptic areaRetinal fibersTract tracingHypothalamic cellsRetinal axonsSynaptic targetsEfferents
1997
Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies
Van Der Beek E, Horvath T, Wiegant V, Van Den Hurk R, Buijs R. Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies. The Journal Of Comparative Neurology 1997, 384: 569-579. PMID: 9259490, DOI: 10.1002/(sici)1096-9861(19970811)384:4<569::aid-cne6>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsSuprachiasmatic nucleusFemale ratsGnRH systemGnRH-immunoreactive cell bodiesGonadotropin-releasing hormone (GnRH) neuronsDaily LH surgesImplantation of estrogenOvariectomized rats resultsRostral ventrolateral portionGonadotropin-releasing hormone (GnRH) systemVasoactive intestinal polypeptideElectron microscopic immunocytochemical studyHormone neuronsGnRH neuronsIntestinal polypeptideLH surgeMonosynaptic pathwayPutative transmittersAnterograde tracerPreoptic areaNeuronal pathwaysRats resultsVentrolateral portionBilateral projectionsFemale rodentsSuprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine.
Horvath T. Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine. Endocrinology 1997, 138: 1312-20. PMID: 9048641, DOI: 10.1210/endo.138.3.4976.Peer-Reviewed Original ResearchConceptsPituitary hormone secretionVasculosum laminae terminalisSuprachiasmatic nucleusHormone secretionNeuroendocrine cellsPreoptic areaLamina terminalisDopamine cellsMedian eminenceAnterior pituitary hormone secretionMedial preoptic areaDiffuse cytoplasmic labelingPhaseolus vulgaris leukoagglutininFluorogold labelingPeriventricular areaArcuate nucleusHypothalamic sitesIP administrationVentromedial nucleusAnterior hypothalamusAnterograde tracerAxon terminalsPeriventricular regionElectron microscopic examinationTyrosine hydroxylase