CPG15 regulates synapse stability in the developing and adult brain
Fujino T, Leslie JH, Eavri R, Chen JL, Lin WC, Flanders GH, Borok E, Horvath TL, Nedivi E. CPG15 regulates synapse stability in the developing and adult brain. Genes & Development 2011, 25: 2674-2685. PMID: 22190461, PMCID: PMC3248687, DOI: 10.1101/gad.176172.111.Peer-Reviewed Original ResearchConceptsSynaptic maturationDendritic spinesFunctional synaptic contactsNeural circuit developmentSynaptic contactsSpine maintenanceDiolistic labelingDendritic arborsMature brainCircuit refinementSynapse stabilityAdult brainKnockout miceSynapse stabilizationCPG15Active synapsesSpine numberActivity-dependent synapseDevelopmental maturationSpineNeuronal branchesCircuit developmentGradual attritionBrainSynapses