Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
Kalra S, Dube M, Pu S, Xu B, Horvath T, Kalra P. Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*. Endocrine Reviews 1999, 20: 68-100. PMID: 10047974, DOI: 10.1210/edrv.20.1.0357.Peer-Reviewed Original ResearchConceptsOrexigenic signalsAppetite-regulating pathwaysInfluence of GABAHypothalamic regulation of body weightNeural timing mechanismNPY-induced feedingCirculating levels of leptinDevelopment of leptin resistanceRegulation of body weightManagement of energy homeostasisCirculating leptin levelsSCN of rodentsLevels of leptinTiming mechanismInterruption of neurotransmissionExpression of NPYNeural mechanismsLeptin gene expressionNeural eventsNeural sitesGene expressionDaily pattern of feedingIngestive behaviorPattern of feedingPostsynaptic level