2005
Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons
Abizaid A, Mezei G, Thanarajasingam G, Horvath TL. Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons. European Journal Of Neuroscience 2005, 21: 1536-1546. PMID: 15845081, DOI: 10.1111/j.1460-9568.2005.03964.x.Peer-Reviewed Original ResearchConceptsOvariectomized ratsRaphe nucleusDorsal raphe serotonergic neuronsEstradiol-treated ovariectomized ratsAbility of estradiolDouble-labeled cellsFos-immunoreactive cellsRaphe serotonergic neuronsMedian raphe nucleusFos-positive nucleiRaphe nuclei regionMidbrain rapheSerotonin immunocytochemistryOvarian functionSerotonergic neuronsEstrogen treatmentFos immunoreactivitySerotonergic systemFood intakeNeuronal responsesDirect projectionsPhotic stimulationEstradiolEstrogenNormal onset
2001
A GABA-neuropeptide Y (NPY) interplay in LH release
Horvath T, Pu S, Dube M, Diano S, Kalra S. A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 2001, 22: 473-481. PMID: 11287104, DOI: 10.1016/s0196-9781(01)00343-6.Peer-Reviewed Original ResearchConceptsGamma-amino butyric acidLH releaseNeurotransmitter/neuromodulatorExcitatory effectsArcuate nucleusReceptor agonistInhibitory gamma-amino butyric acidY4 receptor agonistRelease of LHImmunoreactive axon terminalsRat brain sectionsDose-dependent mannerOvarian steroidsOvariectomized ratsAxon terminalsBrain sectionsPrimary siteNPYMorphological findingsCyclic releaseAgonistsLHNeuromodulatorsRatsAdministration
1993
Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement
Xu B, Sahu A, Crowley WR, Leranth C, Horvath T, Kalra SP. Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement. Endocrinology 1993, 133: 747-754. PMID: 8344213, DOI: 10.1210/endo.133.2.8344213.Peer-Reviewed Original ResearchConceptsEpisodic LH secretionPlasma LH levelsLH releaseLH secretionLH pulsesExcitatory componentLH levelsOVX ratsOvariectomized ratsMean plasma LH levelsAlpha-helical CRHBeta-endorphin neuronsInhibitory LH responseSuppression of LHLH pulse frequencyInfusion of naloxoneContinuous intraventricular infusionFrequency of LHRole of neuropeptidesNormal rabbit serumExogenous NPYNPY injectionLH responseIntracerebroventricular administrationIntraventricular administration
1992
Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis
Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 1992, 131: 2461-2467. PMID: 1425443, DOI: 10.1210/endo.131.5.1425443.Peer-Reviewed Original ResearchConceptsPituitary LH releaseLH releaseOvariectomized ratsMediobasal hypothalamusSynaptic connectionsNPY-immunoreactive axonsBeta-endorphin systemSynaptic membrane specializationsRat mediobasal hypothalamusDirect synaptic connectionsDiaminobenzidine reactionLHRH neuronsNPY neuronsDual effectHypothalamic NPYLH secretionMedial basalLHRH secretionOvarian steroidsPrecise neural mechanismsFemale ratsAxon terminalsElectron microscopic examinationPeptidergic systemsNeuroendocrine regulation