2022
A hypothalamic pathway for Augmentor α–controlled body weight regulation
Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J. A hypothalamic pathway for Augmentor α–controlled body weight regulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2200476119. PMID: 35412887, PMCID: PMC9169862, DOI: 10.1073/pnas.2200476119.Peer-Reviewed Original ResearchConceptsParaventricular nucleusBody weightDiet-induced obesityBody weight regulationDiscrete neuronal populationsMelanocortin receptor 4Whole-body energy homeostasisPhysiological rolePeptide neuronsHypothalamic pathwaysReceptor 4Neuronal pathwaysPhysical activityLittermate controlsWeight regulationNeuronal populationsMetabolic diseasesTherapeutic opportunitiesMutant miceEnergy homeostasisMiceALKCancerHuman cancersALK mutants
2010
Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus
Sotonyi P, Mezei G, Racz B, Dallman MF, Abizaid A, Horvath TL. Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus. Reproductive Sciences 2010, 17: 1024-1028. PMID: 20713970, DOI: 10.1177/1933719110378346.Peer-Reviewed Original ResearchConceptsArcuate nucleusGonadotropin-releasing hormone (GnRH) neuronsPOMC cell bodiesEnergy expenditureHypothalamic arcuate nucleusHypothalamic neuronal populationsMelanocyte stimulating hormoneHormone neuronsPOMC neuronsAnorexigenic proopiomelanocortinStimulating hormoneAnatomical proximityAxon terminalsGonadal axisGlucose homeostasisPeripheral signalsNeuronal populationsCell bodiesDirect appositionGnRHEnergy metabolismNeuronsMetabolic stateHormoneProopiomelanocortin
2000
AMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization study
Zsarnovszky A, Horvath T, Naftolin F, Leranth C. AMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization study. Experimental Brain Research 2000, 133: 532-537. PMID: 10985687, DOI: 10.1007/s002210000425.Peer-Reviewed Original ResearchConceptsArcuate nucleusAMPA receptorsFemale rat arcuate nucleusExcitatory amino acid neurotransmissionIsoxazole propionic acid (AMPA) receptorsAmino acid neurotransmissionTH-ir cellsMajor neuronal populationsRat arcuate nucleusPropionic acid receptorsHormone delivery systemsImmunohistochemical colocalization studiesGlutamatergic innervationGlutamatergic inputsFemale ratsNeuronal populationsGalaninAcid receptorsNeuronsReceptorsNPYNeuropeptidesColocalization studiesPresent studyDelivery system
1999
Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers
Horvath T, Warden C, Hajos M, Lombardi A, Goglia F, Diano S. Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers. Journal Of Neuroscience 1999, 19: 10417-10427. PMID: 10575039, PMCID: PMC6782406, DOI: 10.1523/jneurosci.19-23-10417.1999.Peer-Reviewed Original ResearchConceptsC-Fos-expressing cellsPeripheral energy homeostasisHormone-releasing hormoneHypothalamic neuronal populationsCorticotropin-releasing factorMelanin-concentrating hormoneMitochondria of neuronsUCP2 proteinPeripheral hormonesProximal dendritesNeuropeptide YGonadal steroidsModulates neurotransmissionAxon terminalsBasal brainLocal brainNeuronal populationsAxonal processesNeuronal mitochondriaPeptidergic circuitsBrain circuitsEnergy homeostasisCold exposureNeuronsEndocrine processes
1997
Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
Horvath T, Bechmann I, Naftolin F, Kalra S, Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Research 1997, 756: 283-286. PMID: 9187344, DOI: 10.1016/s0006-8993(97)00184-4.Peer-Reviewed Original ResearchConceptsNeuropeptide YArcuate nucleusGlutamic acid decarboxylaseGamma-aminobutyric acidAcid decarboxylaseDorsomedial arcuate nucleusNeuropeptide Y cellsVentral arcuate nucleusAmino acid transmittersHypothalamic arcuate nucleusHypothalamic neuronal populationsRat arcuate nucleusGABAergic neuronsNeuronal perikaryaNeuropeptide Y.Central regulationAppetitive functionsNeuronal populationsY cellsBehavioral effectsDorsomedial aspectNeuronsVibratome sectionsHypothalamusPerikarya