2011
Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans
Tong J, Mannea E, Aimé P, Pfluger PT, Yi CX, Castaneda TR, Davis HW, Ren X, Pixley S, Benoit S, Julliard K, Woods SC, Horvath TL, Sleeman MM, D'Alessio D, Obici S, Frank R, Tschöp MH. Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans. Journal Of Neuroscience 2011, 31: 5841-5846. PMID: 21490225, PMCID: PMC3089941, DOI: 10.1523/jneurosci.5680-10.2011.Peer-Reviewed Original ResearchConceptsExploratory sniffingAppetite-stimulating hormone ghrelinOlfactory sensitivityOverall functionGhrelin infusionIntracerebroventricular ghrelinGhrelin receptorHormone ghrelinSaline infusionOlfactory functionNeuroendocrine circuitsGhrelinUnderlying neural mechanismsEnergy homeostasisOdor detectionOlfactory processingOlfactory circuitFood seekingNeural mechanismsSniff magnitudeInfusionNovel roleOlfactory detectionSniffingSpecific effects
1999
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
Kalra S, Dube M, Pu S, Xu B, Horvath T, Kalra P. Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*. Endocrine Reviews 1999, 20: 68-100. PMID: 10047974, DOI: 10.1210/edrv.20.1.0357.Peer-Reviewed Original ResearchConceptsOrexigenic signalsAppetite-regulating pathwaysInfluence of GABAHypothalamic regulation of body weightNeural timing mechanismNPY-induced feedingCirculating levels of leptinDevelopment of leptin resistanceRegulation of body weightManagement of energy homeostasisCirculating leptin levelsSCN of rodentsLevels of leptinTiming mechanismInterruption of neurotransmissionExpression of NPYNeural mechanismsLeptin gene expressionNeural eventsNeural sitesGene expressionDaily pattern of feedingIngestive behaviorPattern of feedingPostsynaptic level