2009
GABA Keeps Up an Appetite for Life
Dietrich MO, Horvath TL. GABA Keeps Up an Appetite for Life. Cell 2009, 137: 1177-1179. PMID: 19563747, DOI: 10.1016/j.cell.2009.06.002.Peer-Reviewed Original Research
2001
A GABA-neuropeptide Y (NPY) interplay in LH release
Horvath T, Pu S, Dube M, Diano S, Kalra S. A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 2001, 22: 473-481. PMID: 11287104, DOI: 10.1016/s0196-9781(01)00343-6.Peer-Reviewed Original ResearchConceptsGamma-amino butyric acidLH releaseNeurotransmitter/neuromodulatorExcitatory effectsArcuate nucleusReceptor agonistInhibitory gamma-amino butyric acidY4 receptor agonistRelease of LHImmunoreactive axon terminalsRat brain sectionsDose-dependent mannerOvarian steroidsOvariectomized ratsAxon terminalsBrain sectionsPrimary siteNPYMorphological findingsCyclic releaseAgonistsLHNeuromodulatorsRatsAdministration
2000
Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
Dube M, Horvath T, Kalra P, Kalra S. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 2000, 21: 1557-1560. PMID: 11068104, DOI: 10.1016/s0196-9781(00)00311-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAppetite DepressantsAppetite RegulationCarrier ProteinsEatingFeeding BehaviorInjections, IntraventricularIntracellular Signaling Peptides and ProteinsMaleNaphthalenesNerve Tissue ProteinsNeuronsNeuropeptidesOrexin ReceptorsOrexinsPyrimidinesRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledReceptors, NeuropeptideReceptors, Neuropeptide YSignal TransductionWeight GainConceptsOrexigenic peptideReceptor antagonistSated ratsNPY Y1 receptor antagonistNPY-producing neuronsPotent orexigenic peptideNPY Y5 receptor antagonistsY1 receptor antagonistY5 receptor antagonistsOrexin AIntracerebroventricular injectionY5 receptorsNeuropeptide YReceptor involvementFood intakeStimulate feedingNeuronsAntagonistRatsFeedingOrexinCurrent resultsFunctional linkHypothalamusNPYAMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization study
Zsarnovszky A, Horvath T, Naftolin F, Leranth C. AMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization study. Experimental Brain Research 2000, 133: 532-537. PMID: 10985687, DOI: 10.1007/s002210000425.Peer-Reviewed Original ResearchConceptsArcuate nucleusAMPA receptorsFemale rat arcuate nucleusExcitatory amino acid neurotransmissionIsoxazole propionic acid (AMPA) receptorsAmino acid neurotransmissionTH-ir cellsMajor neuronal populationsRat arcuate nucleusPropionic acid receptorsHormone delivery systemsImmunohistochemical colocalization studiesGlutamatergic innervationGlutamatergic inputsFemale ratsNeuronal populationsGalaninAcid receptorsNeuronsReceptorsNPYNeuropeptidesColocalization studiesPresent studyDelivery system
1999
Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations
Horvath T, Diano S, van den Pol A. Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal Of Neuroscience 1999, 19: 1072-1087. PMID: 9920670, PMCID: PMC6782143, DOI: 10.1523/jneurosci.19-03-01072.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsChlorocebus aethiopsEndocrine GlandsFemaleHypothalamusIntracellular Signaling Peptides and ProteinsMaleMetabolismNeural PathwaysNeuronsNeuropeptide YNeuropeptidesOrexin ReceptorsOrexinsRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, G-Protein-CoupledReceptors, LeptinReceptors, NeuropeptideSynapsesConceptsHypothalamic functionCentral regulationHypocretin-containing neuronsLateral hypothalamic cellsLeptin receptor immunoreactivityNeuropeptide Y cellsDirect synaptic contactsNeuropeptide Y systemEndocrine regulationEndocrine processesNPY releaseReceptor immunoreactivityExcitatory actionHypocretin cellsSynaptic contactsArcuate nucleusLateral hypothalamusPrimate hypothalamusLeptin receptorSame neuronsHypothalamic cellsSynaptic regulationAdipose tissueHypocretinNPY