2011
Obesity is associated with hypothalamic injury in rodents and humans
Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. Obesity is associated with hypothalamic injury in rodents and humans. Journal Of Clinical Investigation 2011, 122: 153-162. PMID: 22201683, PMCID: PMC3248304, DOI: 10.1172/jci59660.Peer-Reviewed Original ResearchConceptsHigh-fat dietHFD feedingMediobasal hypothalamusPeripheral tissuesRodent modelsBody weight controlHypothalamic arcuate nucleusSubstantial weight gainConsequences of obesityNeuron injuryHypothalamic injuryNeuronal injuryNeuroprotective mechanismsReactive gliosisObese humansHypothalamic areaArcuate nucleusInflammatory signalingBrain areasWeight controlObesityGliosisEnergy homeostasisWeight gainInflammation
1995
Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus
Horvath T, Kalra S, Naftolin F, Leranth C. Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus. Journal Of Neuroendocrinology 1995, 7: 579-588. PMID: 8704731, DOI: 10.1111/j.1365-2826.1995.tb00795.x.Peer-Reviewed Original ResearchConceptsBeta-endorphin cellsBeta-endorphin neuronsArcuate nucleusBeta-endorphinMediobasal hypothalamusImmunoreactive profilesPituitary hormone secretionBeta-endorphin releaseDay survival periodRat mediobasal hypothalamusDiaminobenzidine reactionGalanin fibersHalász knifeImmunoreactive neuronsHormone secretionContralateral sideFemale ratsHypothalamic galaninProlactin secretionAdditional ratsElectron microscopic examinationPituitary hormonesSurvival periodNeuroendocrine responsesGalaninGalanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus
Horvath T, Leranth C, Kalra S, Naftolin F. Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus. Brain Research 1995, 675: 321-324. PMID: 7540929, DOI: 10.1016/0006-8993(94)01374-q.Peer-Reviewed Original ResearchConceptsPituitary hormone secretionEstrogen receptorHormone secretionMediobasal hypothalamusEstrogen receptor immunoreactivityHypothalamic luteinizing hormoneArcuate nucleus neuronsRat mediobasal hypothalamusPopulations of neuronsGalanin neuronsReceptor immunoreactivityOvarian steroidsEstrogen effectsNucleus neuronsLuteinizing hormoneFemale ratsHormone releaseGalaninHypothalamusNeuronsVibratome sectionsImmunoreactivityReceptorsHormoneSecretion
1992
Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis
Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 1992, 131: 2461-2467. PMID: 1425443, DOI: 10.1210/endo.131.5.1425443.Peer-Reviewed Original ResearchConceptsPituitary LH releaseLH releaseOvariectomized ratsMediobasal hypothalamusSynaptic connectionsNPY-immunoreactive axonsBeta-endorphin systemSynaptic membrane specializationsRat mediobasal hypothalamusDirect synaptic connectionsDiaminobenzidine reactionLHRH neuronsNPY neuronsDual effectHypothalamic NPYLH secretionMedial basalLHRH secretionOvarian steroidsPrecise neural mechanismsFemale ratsAxon terminalsElectron microscopic examinationPeptidergic systemsNeuroendocrine regulationPresence of calbindin and lack of parvalbumin in progesterone receptor-containing neurons of the monkey mediobasal hypothalamus
Horvath TL, Leranth C, Naftolin* F. Presence of calbindin and lack of parvalbumin in progesterone receptor-containing neurons of the monkey mediobasal hypothalamus. Neuroscience 1992, 50: 309-314. PMID: 1436493, DOI: 10.1016/0306-4522(92)90425-2.Peer-Reviewed Original ResearchConceptsProgesterone receptor-containing neuronsReceptor-containing neuronsReceptor-containing cellsCalbindin-immunoreactive neuronsProgesterone receptorAsymmetric synaptic contactsPresence of calbindinCentral nervous systemAfrican green monkeysLight microscopic resultsGABA neuronsGABAergic neuronsPeriventricular areaSynaptic contactsMonkey hypothalamusPostsynaptic targetsExcitatory fibresInfundibular nucleusMediobasal hypothalamusCalcium-binding proteinsNervous systemCalbindin cellsCalbindinNeuronsParvalbumin content