2024
Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Mohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.Peer-Reviewed Original ResearchConceptsHypothalamic feeding centersHormone deficiencyHypothalamic arcuate nucleus neuronsArcuate nucleus neuronsThyroid hormone deficiencyFeeding centerEffects of ghrelinAnorexigenic effectNucleus neuronsPhysiological anorexiaThyroid hormonesNormal physiological functionsGround squirrelsInterbout arousalAnorexiaThirteen-lined ground squirrelsProlonged periodReduced sensitivityPhysiological functionsDeficiency
2003
Estrogen, synaptic plasticity and hypothalamic reproductive aging
Hung AJ, Stanbury MG, Shanabrough M, Horvath TL, Garcia-Segura LM, Naftolin F. Estrogen, synaptic plasticity and hypothalamic reproductive aging. Experimental Gerontology 2003, 38: 53-59. PMID: 12543261, DOI: 10.1016/s0531-5565(02)00183-3.Peer-Reviewed Original ResearchConceptsConstant estrusReproductive agingEstrogen exposureMale ratsAnti-oxidant vitamin EEarly estrogen exposureArcuate nucleus neuronsHypothalamic arcuate nucleus neuronsConstant vaginal estrusHypothalamic failureEstradiol exposureGonadotrophin surgeOvarian estrogenArcuate nucleusConstant diestrusNucleus neuronsOvarian failureElevated estradiolPerikaryal membraneFemale ratsPerinatal periodTesticular androgensRat brainSex steroidsHormonal factors