2013
Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
Domingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, de Araujo IE, Friedman JM. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. ELife 2013, 2: e01462. PMID: 24381247, PMCID: PMC3875383, DOI: 10.7554/elife.01462.Peer-Reviewed Original ResearchConceptsRewarding effectsHormone neuronsMelanin-concentrating hormone (MCH) neuronsMCH neurons projectStriatal dopamine levelsStriatal DA releaseStriatal dopamine releaseMCH neuronsSucrose ingestionNeurons projectDA releaseDopamine levelsDopamine releaseOptogenetic activationNeural pathwaysArtificial sweetenersNeural circuitryNeuronsNormal preferenceFood preferencesFood rewardGlucoseNutrient sensingMiceSweetener sucralose
2010
Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus
Sotonyi P, Mezei G, Racz B, Dallman MF, Abizaid A, Horvath TL. Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus. Reproductive Sciences 2010, 17: 1024-1028. PMID: 20713970, DOI: 10.1177/1933719110378346.Peer-Reviewed Original ResearchConceptsArcuate nucleusGonadotropin-releasing hormone (GnRH) neuronsPOMC cell bodiesEnergy expenditureHypothalamic arcuate nucleusHypothalamic neuronal populationsMelanocyte stimulating hormoneHormone neuronsPOMC neuronsAnorexigenic proopiomelanocortinStimulating hormoneAnatomical proximityAxon terminalsGonadal axisGlucose homeostasisPeripheral signalsNeuronal populationsCell bodiesDirect appositionGnRHEnergy metabolismNeuronsMetabolic stateHormoneProopiomelanocortinEnhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice
Zheng Q, Zhu J, Shanabrough M, Borok E, Benoit SC, Horvath TL, Clegg DJ, Reizes O. Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice. Neuroscience 2010, 171: 1032-1040. PMID: 20923696, PMCID: PMC2991621, DOI: 10.1016/j.neuroscience.2010.09.060.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAlpha-MSHAnalysis of VarianceAnimalsBody WeightDose-Response Relationship, DrugEatingFeeding BehaviorFood DeprivationGene Expression RegulationMaleMiceMice, KnockoutNeuronsNeuropeptide YParaventricular Hypothalamic NucleusProto-Oncogene Proteins c-fosSignal TransductionSyndecan-3Time FactorsConceptsMelanocortin agonist melanotan IISyndecan-3 null miceParaventricular nucleusBody weightNull miceHypothalamic target neuronsNeuropeptide α-MSHRisk of diabetesC-Fos immunoreactivityHypothalamic paraventricular nucleusBody weight regulationWild-type miceTypes of cancerAnorexigenic αAgRP neuronsHormone neuronsHypothalamic circuitsNeuropeptide YAnorexigenic signalingNeuropeptide responsesCardiovascular diseaseFood intakeTarget neuronsMelanotan IIType mice
1997
Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies
Van Der Beek E, Horvath T, Wiegant V, Van Den Hurk R, Buijs R. Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies. The Journal Of Comparative Neurology 1997, 384: 569-579. PMID: 9259490, DOI: 10.1002/(sici)1096-9861(19970811)384:4<569::aid-cne6>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsSuprachiasmatic nucleusFemale ratsGnRH systemGnRH-immunoreactive cell bodiesGonadotropin-releasing hormone (GnRH) neuronsDaily LH surgesImplantation of estrogenOvariectomized rats resultsRostral ventrolateral portionGonadotropin-releasing hormone (GnRH) systemVasoactive intestinal polypeptideElectron microscopic immunocytochemical studyHormone neuronsGnRH neuronsIntestinal polypeptideLH surgeMonosynaptic pathwayPutative transmittersAnterograde tracerPreoptic areaNeuronal pathwaysRats resultsVentrolateral portionBilateral projectionsFemale rodents
1994
25 Electron Microscopic Double and Triple Labeling Immunocytochemistry in Elucidation of Synaptological Interactions between Ovarian Steroid-Sensitive Neurons and Circuits
Leranth C, Naftolin F, Shanabrough M, Horvath T. 25 Electron Microscopic Double and Triple Labeling Immunocytochemistry in Elucidation of Synaptological Interactions between Ovarian Steroid-Sensitive Neurons and Circuits. International Review Of Neurobiology 1994, 22: 403-434. DOI: 10.1016/b978-0-12-185292-4.50031-0.Peer-Reviewed Original ResearchDouble immunostaining techniqueHormone-releasing hormone (LHRH) neuronsSteroid-sensitive neuronsImmunostaining techniquesRetrograde tracer techniqueTriple-labeling immunocytochemistryHormone neuronsDouble immunostainingTissue antigensDifferent anestheticsAnatomical basisSame satisfactory resultsTissue preparationsNeuronsElectron microscopicElectron-dense labelKetaminePentobarbitalAnestheticsImmunostainingAntigenDegenerationMethoxyfluraneChloropentAntibodies
1992
GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area
Horvath TL, Naftolin F, Leranth C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area. Neuroscience 1992, 51: 391-399. PMID: 1281529, DOI: 10.1016/0306-4522(92)90323-t.Peer-Reviewed Original ResearchConceptsMedial preoptic areaPreoptic areaHormone-producing cellsArcuate nucleusHypothalamic beta-endorphin neuronsHormone-releasing hormone (LHRH) neuronsBeta-endorphin neuronsDirect estrogen actionHormone-containing neuronsVentromedial arcuate nucleusRetrograde tracer horseradish peroxidasePro-opiomelanocortin (POMC) neuronsCellular estrogen receptorsPro-opiomelanocortin cellsTracer horseradish peroxidaseΒ-endorphin cellsHormone neuronsImmunoreactive neuronsCatecholaminergic innervationCatecholaminergic neuronsRetrograde tracingSynaptic contactsEstrogen actionCatecholamine fibersAxon terminals