2015
Ghrelin
Müller T, Nogueiras R, Andermann M, Andrews Z, Anker S, Argente J, Batterham R, Benoit S, Bowers C, Broglio F, Casanueva F, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole P, Cowley M, Cummings D, Dagher A, Diano S, Dickson S, Diéguez C, Granata R, Grill H, Grove K, Habegger K, Heppner K, Heiman M, Holsen L, Holst B, Inui A, Jansson J, Kirchner H, Korbonits M, Laferrère B, LeRoux C, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger P, Schwartz T, Seeley R, Sleeman M, Sun Y, Sussel L, Tong J, Thorner M, van der Lely A, van der Ploeg L, Zigman J, Kojima M, Kangawa K, Smith R, Horvath T, Tschöp M. Ghrelin. Molecular Metabolism 2015, 4: 437-460. PMID: 26042199, PMCID: PMC4443295, DOI: 10.1016/j.molmet.2015.03.005.Peer-Reviewed Original ResearchGastrointestinal peptide hormone ghrelinGrowth hormone secretagogue receptorSleep/wake rhythmGastric acid secretionSystemic energy metabolismPeptide hormone ghrelinPeripheral actionsGut motilitySecretagogue receptorHormone ghrelinAcid secretionGlucose metabolismGhrelinEndogenous ligandTaste sensationEnergy metabolismSecretionMetabolismDiverse biological functionsYearsHormone
2011
Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans
Tong J, Mannea E, Aimé P, Pfluger PT, Yi CX, Castaneda TR, Davis HW, Ren X, Pixley S, Benoit S, Julliard K, Woods SC, Horvath TL, Sleeman MM, D'Alessio D, Obici S, Frank R, Tschöp MH. Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans. Journal Of Neuroscience 2011, 31: 5841-5846. PMID: 21490225, PMCID: PMC3089941, DOI: 10.1523/jneurosci.5680-10.2011.Peer-Reviewed Original ResearchConceptsExploratory sniffingAppetite-stimulating hormone ghrelinOlfactory sensitivityOverall functionGhrelin infusionIntracerebroventricular ghrelinGhrelin receptorHormone ghrelinSaline infusionOlfactory functionNeuroendocrine circuitsGhrelinUnderlying neural mechanismsEnergy homeostasisOdor detectionOlfactory processingOlfactory circuitFood seekingNeural mechanismsSniff magnitudeInfusionNovel roleOlfactory detectionSniffingSpecific effects
2008
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals. Nature 2008, 454: 846-851. PMID: 18668043, PMCID: PMC4101536, DOI: 10.1038/nature07181.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAnimalsCarnitine O-PalmitoyltransferaseFatty AcidsFeeding BehaviorGene Expression RegulationGhrelinHypothalamusIon ChannelsMembrane Potential, MitochondrialMiceMitochondriaMitochondrial ProteinsNeuronsNeuropeptide YPhosphorylationReactive Oxygen SpeciesSynapsesUncoupling Protein 2ConceptsNPY/AgRP neuronsAgRP neuronsNeuronal activityCo-express neuropeptide YGut-derived hormone ghrelinAgRP neuronal activityArcuate nucleus neuronsFatty acid oxidation pathwayHypothalamic mitochondrial respirationG protein-coupled receptorsGhrelin actionNeuropeptide YNucleus neuronsHormone ghrelinFood intakeGhrelinFree radicalsSynaptic plasticityNeuronal functionIntracellular mechanismsNeuronsMitochondrial mechanismsProtein 2Mitochondrial proliferationRobust changes
2006
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal Of Clinical Investigation 2006, 116: 3229-3239. PMID: 17060947, PMCID: PMC1618869, DOI: 10.1172/jci29867.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAppetiteDopamineFluorescent Antibody TechniqueGhrelinMaleMesencephalonMiceMice, Inbred C57BLMice, KnockoutNeuronsNucleus AccumbensPatch-Clamp TechniquesPeptide HormonesRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledReceptors, GhrelinTime FactorsVentral Tegmental AreaConceptsVentral tegmental areaGHSR-deficient miceGHSR-dependent mannerGut hormone ghrelinDopamine neuronal activityMidbrain dopamine neuronsMesolimbic reward circuitrySynaptic input organizationPeripheral ghrelinRebound feedingVTA administrationOrexigenic effectDopamine turnoverGHSR antagonistDopamine neuronsHypothalamic centersTegmental areaHormone ghrelinNucleus accumbensGhrelinNeuronal activitySynapse formationReward circuitryInput organizationFeeding schedule
2003
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis. Neuron 2003, 37: 649-661. PMID: 12597862, DOI: 10.1016/s0896-6273(03)00063-1.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAnimalsCentral Nervous SystemCorticotropin-Releasing HormoneEnergy MetabolismFemaleGhrelinHomeostasisHypothalamusIn Vitro TechniquesIntercellular Signaling Peptides and ProteinsLuminescent ProteinsMiceMice, KnockoutMice, TransgenicNerve NetNeuronsNeuropeptide YOrgan SpecificityParaventricular Hypothalamic NucleusPatch-Clamp TechniquesPeptide HormonesPresynaptic TerminalsPro-OpiomelanocortinProtein BindingProtein BiosynthesisProteinsRatsConceptsCorticotropin-releasing hormoneNeuropeptide YNPY neuronsHypothalamic circuitsGastrointestinal peptide hormone ghrelinEffects of NPYEnergy homeostasisArcuate NPY neuronsRelease of ghrelinExpression of ghrelinMechanism of actionPeptide hormone ghrelinHypothalamic actionOrexigenic peptideHypothalamic nucleiHormone ghrelinParaventricular nucleusProopiomelanocortin (POMC) productsThird ventricleGhrelinPresynaptic terminalsElectrophysiological recordingsNeuronsHypothalamusHomeostasisGhrelin as a potential anti-obesity target.
Horvath TL, Castañeda T, Tang-Christensen M, Pagotto U, Tschöp MH. Ghrelin as a potential anti-obesity target. Current Pharmaceutical Design 2003, 9: 1383-95. PMID: 12769730, DOI: 10.2174/1381612033454748.Peer-Reviewed Original ResearchConceptsPositive energy balancePotential anti-obesity targetEndogenous growth hormone secretagogueEffective pharmacological treatmentAnti-obesity targetGrowth hormone secretagoguesNumerous target tissuesPeptide hormone ghrelinGhrelin antagonistGhrelin actionPharmacological treatmentHormone ghrelinFood intakeHormone secretagoguesPharmacological approachesGhrelinPleiotropic hormoneFat oxidationNeuroendocrine regulationCompensatory mechanismsEnergy homeostasisBlood streamTarget tissuesExact mechanismObesityGhrelin in hypothalamic regulation of energy balance.
Horvath TL, Diano S, Tschöp M. Ghrelin in hypothalamic regulation of energy balance. Current Topics In Medicinal Chemistry 2003, 3: 921-7. PMID: 12678840, DOI: 10.2174/1568026033452230.Peer-Reviewed Original Research