2023
Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence
Sestan-Pesa M, Shanabrough M, Horvath T, Miletta M. Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence. Biomedicines 2023, 11: 144. PMID: 36672651, PMCID: PMC9855766, DOI: 10.3390/biomedicines11010144.Peer-Reviewed Original ResearchAnxiety-like behaviorGrowth hormone secretagogue receptorTHC exposureAdult miceGHSR knockout miceDepression-like behaviorLate adolescenceWild-type littermatesLong-term useGHSR signalingGhrelin signalingSecretagogue receptorKnockout miceAnimal modelsTetrahydrocannabinol (THC) administrationMental illnessMiceSignificant alterationsGhrelinMarijuana useAdolescenceReceptorsProlonged periodExposureLong-term impact
2003
Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction
Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Molecular Psychiatry 2003, 9: 531-538. PMID: 14569273, DOI: 10.1038/sj.mp.4001435.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFemale ratsBenzodiazepine inverse agonistPrefrontal cortex dysfunctionStress-related disordersSex differencesEstrogen replacementPrefrontal cortex functionDepressive disorderOvariectomized femalesPFC dysfunctionLow dosesCortex functionInverse agonistUncontrollable stressAnxiety disordersDisordersNeurobiological basisDysfunctionRatsPresent studyStress systemExposureMemory taskProestrus