2003
Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction
Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Molecular Psychiatry 2003, 9: 531-538. PMID: 14569273, DOI: 10.1038/sj.mp.4001435.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFemale ratsBenzodiazepine inverse agonistPrefrontal cortex dysfunctionStress-related disordersSex differencesEstrogen replacementPrefrontal cortex functionDepressive disorderOvariectomized femalesPFC dysfunctionLow dosesCortex functionInverse agonistUncontrollable stressAnxiety disordersDisordersNeurobiological basisDysfunctionRatsPresent studyStress systemExposureMemory taskProestrus
2000
Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Leranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.Peer-Reviewed Original ResearchConceptsNigrostriatal dopamine neuronsDopamine neuronsParkinson's diseaseSubstantia nigraDopamine cellsTyrosine hydroxylase-expressing neuronsTyrosine hydroxylase-immunoreactive cellsNigral dopamine systemsEstrogen replacement therapyNew treatment strategiesUnbiased stereological analysisTypes of neuronsProgression of diseaseEstrogen replacementPostmenopausal womenEstrogen deprivationReplacement therapyTreatment strategiesCompact zoneGonadal hormonesLong-term effectsDopamine systemEstrogenDiseaseNeuronsHormonal regulation of hippocampal spine synapse density involves subcortical mediation
Leranth C, Shanabrough M, Horvath TL. Hormonal regulation of hippocampal spine synapse density involves subcortical mediation. Neuroscience 2000, 101: 349-356. PMID: 11074158, DOI: 10.1016/s0306-4522(00)00369-9.Peer-Reviewed Original ResearchConceptsFimbria/fornix transectionSpine synapse densitySpine densitySynapse densityHippocampal spine synapse densitySubcortical structuresSubcortical mediationPyramidal cell spinesFornix transectionHippocampal CA1 subfieldHippocampal synaptic plasticityCA1 pyramidal cellsFimbria/fornixLong-term potentiationEstrogen replacementIpsilateral hippocampusContralateral hippocampusCA1 subfieldMedian raphePyramidal cellsSupramammillary areaAfferent connectionsHippocampal morphologySeptal complexNew synapses