2006
Involvement of the Fas–Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell–only syndrome
Kim S, Yoon Y, Park Y, Seo J, Kim J. Involvement of the Fas–Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell–only syndrome. Fertility And Sterility 2006, 87: 547-553. PMID: 17123522, DOI: 10.1016/j.fertnstert.2006.07.1524.Peer-Reviewed Original ResearchConceptsMaturation arrestActive caspase-3Sertoli cellsCaspase-3Testicular expressionDUTP nick end labeling stainingCases of SCOTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stainingNick end labeling stainingTransferase-mediated dUTP nick-end labeling stainingTesticular biopsy specimensTestes of patientsGerm cellsTranscription-polymerase chain reactionFas-Fas ligand systemRoutine clinical purposesHyperplastic interstitial cellsExpression of FasLExpression of FasBiopsy specimensMAIN OUTCOMEObstructive azoospermiaImmunohistochemical analysisIntense immunostainingLabeling stainingNonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway
Kim S, Kim B, Shim J, Gil J, Yoon Y, Kim J. Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway. Toxicological Sciences 2006, 94: 310-321. PMID: 16984955, DOI: 10.1093/toxsci/kfl114.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsUndifferentiated hES cellsEmbryonic stem cellsHES cellsNeural progenitor cellsEarly embryonic developmentStem cellsProgenitor cellsToxic stress responseChemical-induced apoptosisFas ligand protein expressionFas-Fas ligand pathwayCell replacement therapyEmbryonic developmentCaspase activationES cellsCaspase-8Stress responseDevelopmental stagesDNA fragmentationCell typesFas-FasL interactionCommon environmental contaminantsApoptosisProtein expression
2004
PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT
KIM S, LEE H, YANG H, KIM H, YOON Y. PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT. Systems Biology In Reproductive Medicine 2004, 50: 427-441. PMID: 15669608, DOI: 10.1080/01485010490475093.Peer-Reviewed Original ResearchConceptsTesticular germ cellsEstradiol valerateSerum LH concentrationsSerum testosterone concentrationsGerm cellsWeek old ratsPrepubertal male ratsLH concentrationsMale reproductive organsMale ratsTestosterone concentrationsAdult ratsOld ratsChronic exposureMarked reductionSeminiferous tubulesRatsSeminal vesiclesBcl-2Decreased biosynthesisBax mRNAThree timesTesticular developmentBcl-xL mRNAApoptosis