2007
Functional Axonal Regeneration through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans
Cafferty WB, Yang SH, Duffy PJ, Li S, Strittmatter SM. Functional Axonal Regeneration through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans. Journal Of Neuroscience 2007, 27: 2176-2185. PMID: 17329414, PMCID: PMC2848955, DOI: 10.1523/jneurosci.5176-06.2007.Peer-Reviewed Original ResearchConceptsChondroitin sulfate proteoglycanRole of CSPGsTransgenic miceSensory axon regenerationMotor function recoveryFunctional axonal regenerationCombination-based therapyEnzyme chondroitinase ABCSulfate proteoglycanDorsal hemisectionAxotomized neuronsDorsal rhizotomyCorticospinal axonsCNS injuryFunction recoveryMyelin inhibitorsAxonal regenerationAstrocytic scarLocal efficacyTraumatic injuryAxon regenerationLesion siteInhibitory moleculesFunctional regenerationChondroitinase ABC
2006
Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
Harel NY, Strittmatter SM. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nature Reviews Neuroscience 2006, 7: 603-616. PMID: 16858389, PMCID: PMC2288666, DOI: 10.1038/nrn1957.Peer-Reviewed Original ResearchConceptsCNS regenerationNervous systemCentral pattern generatorImmature nervous systemSpinal cord injuryRegeneration-associated genesMammalian CNS regenerationContext of injuryExperience-dependent plasticityFurther plastic changesInflammatory cellsCord injuryVoluntary inputNervous system developmentRegenerating axonsSensory feedbackInhibitory barrierPlastic changesInhibitory moleculesRegenerative responseGuidance moleculesAltered distributionNeuronal branchesInjuryGuidance factors