A Novel Murine Knock‐in Model for Progranulin‐deficient Frontotemporal Dementia with Nonsense‐mediated mRNA Decay
Nguyen A, Nguyen T, Zhang J, Devireddy S, Zhou P, Karydas A, Xu X, Miller B, Rigo F, Ferguson S, Huang E, Walther T, Farese R. A Novel Murine Knock‐in Model for Progranulin‐deficient Frontotemporal Dementia with Nonsense‐mediated mRNA Decay. The FASEB Journal 2018, 32: 807.8-807.8. DOI: 10.1096/fasebj.2018.32.1_supplement.807.8.Peer-Reviewed Original ResearchFrontotemporal dementiaMRNA levelsProgranulin-deficient frontotemporal dementiaCommon neurodegenerative disorderExcessive grooming behaviorGrn knockout miceCell linesFull-text articlesSynaptic densityProgranulin deficiencyTesting therapiesGRN mutationsTherapeutic approachesKnockout miceAnimal modelsAge 60GRN mRNA levelsNeurodegenerative disordersNonsense mutationMiceProgranulin proteinText articlesNational InstituteTypes of mutationsDementia research