2024
Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport
Wu Y, Ding C, Sharif B, Weinreb A, Swaim G, Hao H, Yogev S, Watanabe S, Hammarlund M. Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport. Journal Of Cell Biology 2024, 223: e202305105. PMID: 38470363, PMCID: PMC10932739, DOI: 10.1083/jcb.202305105.Peer-Reviewed Original ResearchConceptsKinesin-1C. elegansN-terminal domainRetrograde trafficAnterograde trafficTransport mitochondriaMitochondria transportPolar localizationMiro-1CRISPR engineeringMitochondria localizationDisordered regionsMitochondriaTransport complexMitochondria distributionAxonal transportAnterograde transportAnterograde axonal transportMotor complexMiroAdaptorCRISPRGenesOptimizing Visualization of Axonal Transport of Endogenous Cargo by Fluorescence Microscopy in Living Caenorhabditis elegans.
Glomb O, Lyu M, Yogev S. Optimizing Visualization of Axonal Transport of Endogenous Cargo by Fluorescence Microscopy in Living Caenorhabditis elegans. Journal Of Visualized Experiments 2024 PMID: 38436410, DOI: 10.3791/66236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonal TransportAxonsCaenorhabditis elegansLissamine Green DyesMicroscopy, FluorescenceConceptsSynaptic vesicle precursorsCaenorhabditis elegansAxonal cargosLoss of axonal transportCRISPR-Cas9 genome editingAxonal transportImpairs neuronal growthNeuronal cell biologySite of synthesisCas9 genome editingRAB-3Vesicle precursorsC. elegansGenome editingEndogenous labelingEndogenous cargoAxonal proteinsLiving Caenorhabditis elegansCell biologyCytoplasmic backgroundFluorescence microscopyCargoNeuronal growthNeuronal cell bodiesCaenorhabditis
2023
A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans
Glomb O, Swaim G, Munoz LLancao P, Lovejoy C, Sutradhar S, Park J, Wu Y, Cason S, Holzbaur E, Hammarlund M, Howard J, Ferguson S, Gramlich M, Yogev S. A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans. Developmental Cell 2023, 58: 1847-1863.e12. PMID: 37751746, PMCID: PMC10574138, DOI: 10.1016/j.devcel.2023.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonal TransportAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsKinesinsSpectrin
2017
Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution
Yogev S, Maeder CI, Cooper R, Horowitz M, Hendricks AG, Shen K. Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution. Nature Communications 2017, 8: 15063. PMID: 28406181, PMCID: PMC5399302, DOI: 10.1038/ncomms15063.Peer-Reviewed Original Research
2016
Microtubule Organization Determines Axonal Transport Dynamics
Yogev S, Cooper R, Fetter R, Horowitz M, Shen K. Microtubule Organization Determines Axonal Transport Dynamics. Neuron 2016, 92: 449-460. PMID: 27764672, PMCID: PMC5432135, DOI: 10.1016/j.neuron.2016.09.036.Peer-Reviewed Original Research