1998
Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations
Komuro H, Rakic P. Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. Developmental Neurobiology 1998, 37: 110-130. PMID: 9777736, DOI: 10.1002/(sici)1097-4695(199810)37:1<110::aid-neu9>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsGranule cellsNeurotransmitter receptorsGranule cell movementN-methyl-D-aspartate (NMDA) subtypeN-type Ca2Different cortical layersIon channelsAcute cerebellar slicesFrequency of Ca2Local cellular milieuPhase of Ca2Position-specific changesVoltage-gated ion channelsGlutamate receptorsSpecific ion channelsCerebellar slicesIntracellular Ca2Transient Ca2Cortical layersReceptor activityNeuronal migrationReceptorsPlasmalemmal surfaceLocal environmental cuesCell migrationDistinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornCell MovementCerebellar CortexGranulocytesMiceMice, Inbred StrainsNeuronsPurkinje CellsTime FactorsConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1996
Polarity of microtubule assemblies during neuronal cell migration.
Rakic P, Knyihar-Csillik E, Csillik B. Polarity of microtubule assemblies during neuronal cell migration. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9218-9222. PMID: 8799181, PMCID: PMC38622, DOI: 10.1073/pnas.93.17.9218.Peer-Reviewed Original Research
1995
The role of receptor/channel activity in neuronal cell migration
Rakic P, Komuro H. The role of receptor/channel activity in neuronal cell migration. Developmental Neurobiology 1995, 26: 299-315. PMID: 7775964, DOI: 10.1002/neu.480260303.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium ChannelsCell MovementCerebellar CortexIon Channel GatingModels, NeurologicalNeuronsReceptors, N-Methyl-D-AspartateConceptsNeuronal cell migrationCell migrationIon channelsLocal cellular milieuSpecific ion channelsCell motilityCytoskeletal proteinsConfocal laser microscopyCellular milieuPostmitotic neuronsSecond messengerCellular mechanismsChannel activityLaser microscopyMotilitySynaptic connectionsExplant culturesEarly interactionsCellsFluorescent indicatorProteinMessengerMigrationPrior formationCarbocyanine dye
1989
GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum
Meinecke D, Tallman J, Rakic P. GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum. Brain Research 1989, 493: 303-319. PMID: 2548668, DOI: 10.1016/0006-8993(89)91165-7.Peer-Reviewed Original ResearchConceptsReceptor-like immunoreactivityGABAA/benzodiazepine receptorGolgi type II cellsType II cellsAxon terminalsBasket cellsBenzodiazepine receptorsCerebellar cortexCortical layersII cellsMonkey cerebellumUnlabeled axon terminalsCytoplasm of neuronsMossy fiber terminalsDeep cerebellar nucleiImmunoreactive dendritesSymmetric synapsesImmunostained neuronsInhibitory circuitsLabel neuronsGlial cellsNeuronal typesFiber terminalsGranule cellsStellate cells
1985
Differential distribution of intermembranous particles in the plasmalemma of the migrating cerebellar granule cells.
Garcia-Segura L, Rakic P. Differential distribution of intermembranous particles in the plasmalemma of the migrating cerebellar granule cells. Brain Research 1985, 355: 145-9. PMID: 4075101, DOI: 10.1016/0165-3806(85)90014-8.Peer-Reviewed Original Research
1978
Mechanisms of Cortical Development: A View From Mutations in Mice
Caviness V, Rakic P. Mechanisms of Cortical Development: A View From Mutations in Mice. Annual Review Of Neuroscience 1978, 1: 297-326. PMID: 386903, DOI: 10.1146/annurev.ne.01.030178.001501.Peer-Reviewed Original Research
1976
Differentiation of Purkinje cells and their relationship to other components of developing cerebellar cortex in man
Zecevic N, Rakic P. Differentiation of Purkinje cells and their relationship to other components of developing cerebellar cortex in man. The Journal Of Comparative Neurology 1976, 167: 27-47. PMID: 818132, DOI: 10.1002/cne.901670103.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCerebellar CortexDendritesHaplorhiniHumansPurkinje CellsSpecies SpecificityConceptsPurkinje cellsSomatic spinesCerebellar cortexPurkinje cell somatic spinesGolgi impregnation methodFirst postnatal yearTime of birthHuman Purkinje cellsNew dendritic branchesPurkinje cell maturationBipolar somataPostnatal ageDendritic shaftsIntrauterine lifeDendritic arborsFetal weekDendritic processesPostnatal yearFetal monthCell maturationPrimate cerebellumNeuronal differentiationHuman specimensDendritic branchesBasal cell pole
1973
Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice
Rakic P, Sidman R. Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice. The Journal Of Comparative Neurology 1973, 152: 133-161. PMID: 4761656, DOI: 10.1002/cne.901520203.Peer-Reviewed Original ResearchConceptsGranule cellsExternal granular layerGolgi type II neuronsPurkinje cellsHeterozygous weaver miceType II neuronsMossy fiber terminalsWeaver mutant micePurkinje cell dendritesGranular layerExternal granule cellsIntrinsic axonsLocal cellular milieuSynaptic contactsForm synapsesEarly recognitionAxonal contactCell dendritesPostsynaptic elementsBergmann glial fibersMembrane thickeningMossy fibersDendritic spinesFiber terminalsMolecular layerSequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice
Rakic P, Sidman R. Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice. The Journal Of Comparative Neurology 1973, 152: 103-132. PMID: 4128371, DOI: 10.1002/cne.901520202.Peer-Reviewed Original ResearchNeuronal migration, with special reference to developing human brain: a review
Sidman R, Rakic P. Neuronal migration, with special reference to developing human brain: a review. Brain Research 1973, 62: 1-35. PMID: 4203033, DOI: 10.1016/0006-8993(73)90617-3.Peer-Reviewed Original ResearchConceptsCerebellar cortexNervous systemRadial glial guidesGranule cell neuronsCentral nervous systemFetal human brainHuman brainImmunological definitionCerebral cortexCortical plateYoung neuronsAfferent axonsBergmann glial fibersGlial guidesCNS cellsGray nucleiGanglionic eminenceInferior oliveCell neuronsGlial fibersHuman nervous systemMutant miceNeuronal migrationNeuronsCortex
1972
Extrinsic cytological determinants of basket and stellate cell dendritic pattern in the cerebellar molecular layer
Rakic P. Extrinsic cytological determinants of basket and stellate cell dendritic pattern in the cerebellar molecular layer. The Journal Of Comparative Neurology 1972, 146: 335-354. PMID: 4628749, DOI: 10.1002/cne.901460304.Peer-Reviewed Original Research
1971
Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesus
Rakic P. Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesus. The Journal Of Comparative Neurology 1971, 141: 283-312. PMID: 4101340, DOI: 10.1002/cne.901410303.Peer-Reviewed Original Research
1970
Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans
Rakic P, Sidman R. Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. The Journal Of Comparative Neurology 1970, 139: 473-500. PMID: 4195699, DOI: 10.1002/cne.901390407.Peer-Reviewed Original Research