2000
Radial Unit Hypothesis of Neocortical Expansion
Rakic P. Radial Unit Hypothesis of Neocortical Expansion. Novartis Foundation Symposia 2000, 228: 30-45. PMID: 10929315, DOI: 10.1002/0470846631.ch3.Peer-Reviewed Original ResearchConceptsRadial unit hypothesisSpecies-specific sizeFamily of genesMutations of genesVentricular zoneMammalian evolutionFounder cellsNatural selectionRegulatory genesCell divisionMorphoregulatory moleculesPostmitotic cellsTransgenic animalsCortical plateCell deathNeocortical expansionGenesBasic organizationGlial scaffoldingColumnar unitsCortical cellsCerebral cortexCellsCortical developmentSynaptic connections
1999
Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior region
1997
Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody
Wikler K, Rakic P, Bhattacharyya N, Macleish P. Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody. The Journal Of Comparative Neurology 1997, 377: 500-508. PMID: 9007188, DOI: 10.1002/(sici)1096-9861(19970127)377:4<500::aid-cne2>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsPrimate retinaFetal retinaMonoclonal antibodiesAdult primate retinaEmbryonic day 80Opsin-positive conesOuter plexiform layerNovel monoclonal antibodyPopulation of conesShort-wavelength sensitive conesDouble-labeling experimentsSynaptic contactsPlexiform layerPhotoreceptor layerWavelength-sensitive conesMacaque monkeysSynaptic connectionsFetal ageRetinaDay 80Cone genesisCone opsinsImmunoreactivityAntibodiesInitial differentiation
1995
The role of receptor/channel activity in neuronal cell migration
Rakic P, Komuro H. The role of receptor/channel activity in neuronal cell migration. Developmental Neurobiology 1995, 26: 299-315. PMID: 7775964, DOI: 10.1002/neu.480260303.Peer-Reviewed Original ResearchConceptsNeuronal cell migrationCell migrationIon channelsLocal cellular milieuSpecific ion channelsCell motilityCytoskeletal proteinsConfocal laser microscopyCellular milieuPostmitotic neuronsSecond messengerCellular mechanismsChannel activityLaser microscopyMotilitySynaptic connectionsExplant culturesEarly interactionsCellsFluorescent indicatorProteinMessengerMigrationPrior formationCarbocyanine dye
1991
Development of the Primate Visual System Throughout Life
Rakic P. Development of the Primate Visual System Throughout Life. NATO Science Series A: 1991, 1-9. DOI: 10.1007/978-1-4615-3390-0_1.Peer-Reviewed Original ResearchComplex primate brainLateral geniculate nucleusComputer-aided quantitative methodAdditional relevant literatureGeniculate nucleusBrain maturationEntire visual systemPrimate brainPrimate visual systemVisual systemSynaptic connectionsBiochemical maturationRhesus monkeysCytoarchitectonic mapsFunctional circuitryNonhuman primatesLongitudinal studyPathological developmentMaturationRelevant literature
1990
Hypercolumns in primate visual cortex can develop in the absence of cues from photoreceptors.
Kuljis R, Rakic P. Hypercolumns in primate visual cortex can develop in the absence of cues from photoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 5303-5306. PMID: 2164675, PMCID: PMC54311, DOI: 10.1073/pnas.87.14.5303.Peer-Reviewed Original ResearchConceptsLayers II/IIINeuropeptide YInterblob regionsVisual cortexAspiny stellate cellsCytochrome oxidase-rich blobsCytochrome oxidase blobsPrimate visual cortexRetinal ablationCerebral cortexRetinal neuronsDistinct physiological propertiesControl animalsStellate cellsOperated animalsMacaque monkeysSynaptic connectionsCortexPattern visionRetinal photoreceptorsNeuronsChemoarchitectonic organizationAbsence of cuesColor visionPhotoreceptors
1989
Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life
Zecevic N, Bourgeois J, Rakic P. Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life. Brain Research 1989, 50: 11-32. PMID: 2582602, DOI: 10.1016/0165-3806(89)90124-7.Peer-Reviewed Original ResearchConceptsMotor cortexSynaptic densityCortical plateRhesus monkeysDensity of synapsesTransient subplate zonePrimate motor cortexSecond postnatal monthTime of birthVolume of neuropilMicrons 3Non-human primatesSubplate zoneSymmetric synapsesAsymmetric synapsesDendritic shaftsSynaptic contactsLaminar distributionFirst synapsePostnatal monthDendritic spinesPostnatal lifeSynaptic connectionsAdult levelsCortex
1981
Development of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth
Rakic P. Development of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth. Science 1981, 214: 928-931. PMID: 7302569, DOI: 10.1126/science.7302569.Peer-Reviewed Original ResearchConceptsVisual centersPrimate brainAberrant synaptic connectionsLateral geniculate nucleusOcular dominance columnsGeniculate neuronsGeniculate nucleusSynaptic connectivityIntact eyeVisual cortexSynaptic connectionsBinocular competitionCellular layersBrainBirthNotable alterationsEyesNormal inputFiber bandsCortexNeurons