Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
Kuida K, Haydar T, Kuan C, Gu Y, Taya C, Karasuyama H, Su M, Rakic P, Flavell R. Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9. Cell 1998, 94: 325-337. PMID: 9708735, DOI: 10.1016/s0092-8674(00)81476-2.Peer-Reviewed Original ResearchConceptsCritical upstream activatorUpstream activatorCaspase-9Cell death machineryCytochrome cDeath machineryApoptotic stimuliCaspase activationCaspase cascadeDNA fragmentationPrevents activationCytosolic extractsEmbryonic brainCaspasesReduced apoptosisCASP9ApoptosisActivatorCASP3Brain developmentKnockout miceEssential componentCleavageActivationVivo